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For predicting cancer survival outcomes, standard approaches in clinical research are often based on two main modalities: pathology images for observing cell morphology features, and genomic (e.g., bulk RNA-seq) for quantifying gene…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongxiao Wang , Yang Yang , Zhuo Zhao , Pengfei Gu , Nishchal Sapkota , Danny Z. Chen

Deep learning has achieved remarkable success across many domains, but it has also created a growing demand for interpretability in model predictions. Although many explainable machine learning methods have been proposed, post-hoc…

Machine Learning · Computer Science 2026-01-28 Shijian Xu , Marcello Massimo Negri , Volker Roth

Head and Neck Squamous Cell Carcinoma (HNSCC) is one of cancer type that is most distressing leading to acute pain, effecting speech and primary survival functions such as swallowing and breathing. The morbidity and mortality of HNSCC…

Genomics · Quantitative Biology 2021-05-18 Saurav Mandal , Akshansh Gupta , Waribam Pratibha Chanu

This paper focuses on the task of survival time analysis for lung cancer. Although much progress has been made in this problem in recent years, the performance of existing methods is still far from satisfactory. Traditional and some deep…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Yujiao Wu , Yaxiong Wang , Xiaoshui Huang , Fan Yang , Sai Ho Ling , Steven Weidong Su

Lung cancer remains one of the leading causes of cancer-related mortality worldwide. Conventional computed tomography (CT) imaging, while essential for detection and staging, has limitations in distinguishing benign from malignant lesions…

Image and Video Processing · Electrical Eng. & Systems 2026-04-20 Baramee Sukumal , Aueaphum Aueawatthanaphisut

Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Emmanuella Avwerosuoghene Oghenekaro

Accurate and interpretable survival analysis remains a core challenge in oncology. With growing multimodal data and the clinical need for transparent models to support validation and trust, this challenge increases in complexity. We propose…

Artificial Intelligence · Computer Science 2025-09-29 Mafalda Malafaia , Peter A. N. Bosman , Coen Rasch , Tanja Alderliesten

Early and accurate prediction of overall survival (OS) time can help to obtain better treatment planning for brain tumor patients. Although many OS time prediction methods have been developed and obtain promising results, there are still…

Image and Video Processing · Electrical Eng. & Systems 2020-07-16 Tao Zhou , Huazhu Fu , Yu Zhang , Changqing Zhang , Xiankai Lu , Jianbing Shen , Ling Shao

This work investigates the role of the emerging Analog In-memory computing (AIMC) paradigm in enabling Medical AI analysis and improving the certainty of these models at the edge. It contrasts AIMC's efficiency with traditional digital…

Image and Video Processing · Electrical Eng. & Systems 2024-03-15 Imane Hamzaoui , Hadjer Benmeziane , Zayneb Cherif , Kaoutar El Maghraoui

Multimodal clinical data are characterized by high dimensionality, heterogeneous representations, and structured missingness, posing significant challenges for predictive modeling, data integration, and interpretability. We propose BIONIC…

We present a novel approach for the prediction of anticancer compound sensitivity by means of multi-modal attention-based neural networks (PaccMann). In our approach, we integrate three key pillars of drug sensitivity, namely, the molecular…

Integrating the different data modalities of cancer patients can significantly improve the predictive performance of patient survival. However, most existing methods ignore the simultaneous utilization of rich semantic features at different…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Liangrui Pan , Yijun Peng , Yan Li , Yiyi Liang , Liwen Xu , Qingchun Liang , Shaoliang Peng

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease…

Machine Learning · Computer Science 2026-03-10 Zahra Jafari , Azadeh Zamanifar , Amirfarhad Farhadi

Developing computational tools for integrative analysis across multiple types of omics data has been of immense importance in cancer molecular biology and precision medicine research. While recent advancements have yielded integrative…

Multimodal self-supervised pretraining offers a promising route to cancer prognosis by integrating histopathology whole-slide images, gene expression, and pathology reports, yet most existing approaches require fully paired and complete…

Machine Learning · Computer Science 2026-04-08 Kai Yu , Shuang Zhou , Yiran Song , Zaifu Zhan , Jie Peng , Kaixiong Zhou , Tianlong Chen , Feng Xie , Meng Wang , Huazhu Fu , Mingquan Lin , Rui Zhang

Lung and colon cancers are predominant contributors to cancer mortality. Early and accurate diagnosis is crucial for effective treatment. By utilizing imaging technology in different image detection, learning models have shown promise in…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Diponkor Bala , S M Rakib Ul Karim , Rownak Ara Rasul

Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Yuqi Zhang , Xiaoqian Zhang , Jiakai Wang , Yuancheng Yang , Taiying Peng , Chao Tong

Cancer detection and prognosis relies heavily on medical imaging, particularly CT and PET scans. Deep Neural Networks (DNNs) have shown promise in tumor segmentation by fusing information from these modalities. However, a critical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Numan Saeed , Shahad Hardan , Muhammad Ridzuan , Nada Saadi , Karthik Nandakumar , Mohammad Yaqub

Magnetic Resonance (MR) images of different modalities can provide complementary information for clinical diagnosis, but whole modalities are often costly to access. Most existing methods only focus on synthesizing missing images between…

Computer Vision and Pattern Recognition · Computer Science 2020-05-05 Bingyu Xin , Yifan Hu , Yefeng Zheng , Hongen Liao

Magnetic resonance imaging (MRI) is essential for nasopharyngeal carcinoma (NPC) radiotherapy (RT), but practical constraints, such as patient discomfort, long scan times, and high costs often lead to incomplete modalities in clinical…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Yao Pu , Yiming Shi , Zhenxi Zhang , Peixin Yu , Yitao Zhuang , Xiang Wang , Hongzhao Chen , Jing Cai , Ge Ren
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