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Motile eukaryotic cells display distinct modes of migration that often occur within the same cell type. It remains unclear, however, whether transitions between the migratory modes require changes in external conditions, or whether the…

Pattern Formation and Solitons · Physics 2025-05-29 Jack M. Hughes , Cristina Martinez-Torres , Carsten Beta , Leah Edelstein-Keshet , Arik Yochelis

Eukaryotic cell motility involves a complex network of interactions between biochemical components and mechanical processes. The cell employs this network to polarize and induce shape changes that give rise to membrane protrusions and…

Cell Behavior · Quantitative Biology 2022-01-03 E. Moreno , S. Flemming , F. Font , M. Holschneider , C. Beta , S. Alonso

Collective cell migration contributes to embryogenesis, wound healing and tumor metastasis. Cell monolayer migration experiments help understanding what determines the movement of cells far from the leading edge. Inhibiting cell…

Biological Physics · Physics 2018-03-26 S. Tlili , E. Gauquelin , B. Li , O. Cardoso , B. Ladoux , H. Delanoë-Ayari , F. Graner

From bird flocks to fish schools, animal groups often seem to react to environmental perturbations as if of one mind. Most studies in collective animal behaviour have aimed to understand how a globally ordered state may emerge from simple…

Populations and Evolution · Quantitative Biology 2014-10-10 Andrea Cavagna , Alessio Cimarelli , Irene Giardina , Giorgio Parisi , Raffaele Santagati , Fabio Stefanini , Massimiliano Viale

Non-reciprocal interactions in active matter gives rise to a multitude of fascinating phenomena among which are collective oscillatory states without intrinsic particle chirality and active turbulence. Here we show that in a paradigmatic…

Statistical Mechanics · Physics 2026-04-09 Chul-Ung Woo , Jae Dong Noh , Heiko Rieger

Coordinated movements of epithelia tissue are linked with active matter processes. We here consider the influence of curvature on the spatiotemporal arrangements and the shapes of the cells. The cells are represented by a multiphase field…

Soft Condensed Matter · Physics 2023-04-18 Lea Happel , Dennis Wenzel , Axel Voigt

We use a computational phase-field model together with analytical analysis to study how inter-cellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. Contractile inter-cellular…

Soft Condensed Matter · Physics 2021-11-30 Guanming Zhang , Julia M. Yeomans

We study the surface fluctuations of a tissue with a dynamics dictated by cell-rearrangement, cell-division, and cell-death processes. Surface fluctuations are calculated in the homeostatic state, where cell division and cell death…

Biological Physics · Physics 2015-12-22 Thomas Risler , Aurélien Peilloux , Jacques Prost

How do flocks, herds and swarms proceed through disordered environments? This question is not only crucial to animal groups in the wild, but also to virtually all applications of collective robotics, and active materials composed of…

Soft Condensed Matter · Physics 2016-10-17 Alexandre Morin , Nicolas Desreumaux , Jean-Baptiste Caussin , Denis Bartolo

The remarkable cohesion and coordination observed in moving animal groups and their collective responsiveness to threats are thought to be mediated by scale-free correlations, where changes in the behavior of one animal influence others in…

Biological Physics · Physics 2025-06-05 Haotian Hang , Chenchen Huang , Alex Barnett , Eva Kanso

Flocking refers to collective behavior of a large number of interacting entities, where the interactions between discrete individuals produce collective motion on the large scale. We employ an agent-based model to describe the microscopic…

Numerical Analysis · Mathematics 2020-12-23 Zhiping Mao , Zhen Li , George Em Karniadakis

We investigate numerically the dynamics of shape and displacement fluctuations of two-dimensional flexible vesicles filled with active particles. At low concentration most of the active particles accumulate at the boundary of the vesicle…

Statistical Mechanics · Physics 2016-09-29 Matteo Paoluzzi , Roberto Di Leonardo , M Cristina Marchetti , Luca Angelani

Epithelial cells cultured in a monolayer are very motile in isolation but reach a near-jammed state when mitotic division increases their number above a critical threshold. We have recently shown that a monolayer can be reawakened by…

Collections of cells exhibit coherent migration during morphogenesis, cancer metastasis, and wound healing. In many cases, bigger clusters split, smaller sub-clusters collide and reassemble, and gaps continually emerge. The connections…

Biological Physics · Physics 2021-03-31 Ushasi Roy , Andrew Mugler

We experimentally study a monolayer of vibrated disks with a built-in polar asymmetry which enables them to move quasi-balistically on a large persistence length. Alignment occurs during collisions as a result of self-propulsion and hard…

Soft Condensed Matter · Physics 2012-07-12 Julien Deseigne , Olivier Dauchot , Hugues Chatè

Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy…

Soft Condensed Matter · Physics 2019-05-07 Michael Czajkowski , Daniel M. Sussman , M. Cristina Marchetti , M. Lisa Manning

Coherent collective motion is a widely observed phenomenon in active matter systems. Here, we report a flocking transition mechanism in a system of chemically interacting active colloidal particles sustained purely by chemo-repulsive…

Soft Condensed Matter · Physics 2025-11-04 Arvin Gopal Subramaniam , Sagarika Adhikary , Rajesh Singh

Networks of biofilaments are essential for the formation of cellular structures that support various biological functions. For the most part, previous studies have investigated the collective dynamics of rod-like biofilaments; however, the…

Biological Physics · Physics 2016-05-18 Hironobu Nogucci , Shuji Ishihara

We study clustering in a stochastic system of particles sliding down a fluctuating surface in one and two dimensions. In steady state, the density-density correlation function is a scaling function of separation and system size.This scaling…

Statistical Mechanics · Physics 2009-11-13 Mustansir Barma

We consider the effect of spatial anisotropy on polar flocks by investigating active $q$-state clock models in two dimensions. In contrast to what happens in equilibrium, we find that, in the large-size limit, any amount of anisotropy…

Statistical Mechanics · Physics 2024-09-16 Alexandre Solon , Hugues Chaté , John Toner , Julien Tailleur