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Supervised deep learning has shown state-of-the-art performance for medical image segmentation across different applications, including histopathology and cancer research; however, the manual annotation of such data is extremely laborious.…

Clinical dermatology necessitates precision and innovation for efficient diagnosis and treatment of various skin conditions. This paper introduces the development of a cutting-edge hyperspectral dermatoscope (the Hyperscope) tailored for…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Martin J. Hetz , Carina Nogueira Garcia , Sarah Haggenmüller , Titus J. Brinker

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung

We present deepflash2, a deep learning solution that facilitates the objective and reliable segmentation of ambiguous bioimages through multi-expert annotations and integrated quality assurance. Thereby, deepflash2 addresses typical…

Quantitative Methods · Quantitative Biology 2021-11-15 Matthias Griebel , Dennis Segebarth , Nikolai Stein , Nina Schukraft , Philip Tovote , Robert Blum , Christoph M. Flath

Microscopy, in particular scanning probe and electron microscopy, has been pivotal in improving our understanding of structure-function relationships at the nanoscale and is by now ubiquitous in most research characterization labs and…

As artificial intelligence becomes increasingly prevalent, the demand for faster and more energy-efficient computing approaches grows. While optical computing offers intrinsic advantages in bandwidth and power consumption, existing…

In x-ray microscopy, traditional raster-scanning techniques are used to acquire a microscopic image in a series of step-scans. Alternatively, scanning the x-ray probe along a continuous path, called a fly-scan, reduces scan time and…

Image and Video Processing · Electrical Eng. & Systems 2025-09-23 Yu Lu , Thomas F. Lynn , Ming Du , Zichao Di , Sven Leyffer

Fluorescence labeling is the standard approach to reveal cellular structures and other subcellular constituents for microscopy images. However, this invasive procedure may perturb or even kill the cells and the procedure itself is highly…

Image and Video Processing · Electrical Eng. & Systems 2024-06-25 Han Liu , Hao Li , Jiacheng Wang , Yubo Fan , Zhoubing Xu , Ipek Oguz

Bright-field microscopy, a cost-effective solution for live-cell culture, is often the only resource available, along with standard CPUs, for many low-budget labs. The inherent challenges of bright-field images -- their noisiness, low…

Quantitative Methods · Quantitative Biology 2025-11-03 Surajit Das , Pavel Zun

Ovarian cancer remains a challenging malignancy to diagnose and manage, with prognosis heavily dependent on the stage at detection. Accurate grading and staging, primarily based on histopathological examination of biopsy tissue samples, are…

Medical Physics · Physics 2025-05-16 Ashmit K Mishra , Mousa Alrubayan , Prabhakar Pradhan

Large medical image data sets with high dimensionality require substantial amount of computation time for data creation and data processing. This paper presents a novel generalized method that finds optimal image-based feature sets that…

Computer Vision and Pattern Recognition · Computer Science 2016-10-25 Sohini Roychowdhury

With the development of medical imaging technology and machine learning, computer-assisted diagnosis which can provide impressive reference to pathologists, attracts extensive research interests. The exponential growth of medical images and…

Computer Vision and Pattern Recognition · Computer Science 2020-10-08 Xiao Kang , Xingbo Liu , Xiushan Nie , Yilong Yin

Deep learning object detection algorithm has been widely used in medical image analysis. Currently all the object detection tasks are based on the data annotated with object classes and their bounding boxes. On the other hand, medical…

Computer Vision and Pattern Recognition · Computer Science 2020-03-04 Li Xiao , Cheng Zhu , Junjun Liu , Chunlong Luo , Peifang Liu , Yi Zhao

This paper addresses the problem of few-shot skin disease classification by introducing a novel approach called the Sub-Cluster-Aware Network (SCAN) that enhances accuracy in diagnosing rare skin diseases. The key insight motivating the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Shuhan LI , Xiaomeng Li , Xiaowei Xu , Kwang-Ting Cheng

The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often…

Highly clumped nuclei clusters captured in fluorescence in situ hybridization microscopy images are common histology entities under investigations in a wide spectrum of tissue-related biomedical investigations. Due to their large scale in…

Computer Vision and Pattern Recognition · Computer Science 2018-08-15 Xiaoyuan Guo , Hanyi Yu , Blair Rossetti , George Teodoro , Daniel Brat , Jun Kong

In an emergency room (ER) setting, stroke triage or screening is a common challenge. A quick CT is usually done instead of MRI due to MRI's slow throughput and high cost. Clinical tests are commonly referred to during the process, but the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-29 Tongan Cai , Haomiao Ni , Mingli Yu , Xiaolei Huang , Kelvin Wong , John Volpi , James Z. Wang , Stephen T. C. Wong

A lateral shear interferometer based digital holographic microscopy has been realized to study the morphology dynamics of Human red blood cells quantitatively. Here, a lateral shear interferometer is embedded with a conventional microscope…

Image and Video Processing · Electrical Eng. & Systems 2019-09-10 Shital Devinder , Ashish Lal , Tathagato Rai Dastidar , Satish Kumar Dubey

Histopathologic Images (HI) are the gold standard for evaluation of some tumors. However, the analysis of such images is challenging even for experienced pathologists, resulting in problems of inter and intra observer. Besides that, the…

Computer Vision and Pattern Recognition · Computer Science 2019-04-18 Jonathan de Matos , Alceu de Souza Britto , Luiz E. S. Oliveira , Alessandro L. Koerich

Images captured through smartphone cameras often suffer from degradation, blur being one of the major ones, posing a challenge in processing these images for downstream tasks. In this paper we propose low-compute lightweight patch-wise…

Computer Vision and Pattern Recognition · Computer Science 2023-04-07 Sri Charan Kattamuru , Kshitij Agrawal , Shyam Prasad Adhikari , Abhishek Bose , Hemant Misra
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