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The challenge of optimal design of experiments (DOE) pervades materials science, physics, chemistry, and biology. Bayesian optimization has been used to address this challenge in vast sample spaces, although it requires framing experimental…

Complex chemical space and limited knowledge scope with biases holds immense challenge for human scientists, yet in automated materials discovery. Existing intelligent methods relies more on numerical computation, leading to inefficient…

Machine Learning · Computer Science 2025-04-15 Zheyuan Lai , Yingming Pu

Autonomous experimentation enabled by artificial intelligence (AI) offers a new paradigm for accelerating scientific discovery. Non-equilibrium materials synthesis is emblematic of complex, resource-intensive experimentation whose…

Remote science operations require automated systems that can both act and react with minimal human intervention. One such vision is that of an intelligent instrument that collects data in an automated fashion, and based on what it learns,…

Artificial Intelligence · Computer Science 2016-02-24 Kevin H. Knuth , Philip M. Erner , Scott Frasso

The advancement of artificial-intelligence driven autonomous experiments demands physics-based modeling and decision-making processes, not only to improve the accuracy of the experimental trajectory but also to increase trust by allowing…

Soft Condensed Matter · Physics 2025-06-18 Duncan R. Sutherland , Rachel Ford , Yun Liu , Tyler B. Martin , Peter A. Beaucage

The exploration of thermoelectric materials is challenging considering the large materials space, combined with added exponential degrees of freedom coming from doping and the diversity of synthetic pathways. Here we seek to incorporate…

Materials Science · Physics 2023-07-21 Hitarth Choubisa , Md Azimul Haque , Tong Zhu , Lewei Zeng , Maral Vafaie , Derya Baran , Edward H Sargent

Machine learning is rapidly becoming an integral part of experimental physical discovery via automated and high-throughput synthesis, and active experiments in scattering and electron/probe microscopy. This, in turn, necessitates the…

The advent of Large Language Models (LLMs) has created new opportunities for the automation of scientific research spanning both experimental processes and computational simulations. This study explores the feasibility of constructing an…

Artificial Intelligence · Computer Science 2025-01-16 Zhihan Liu , Yubo Chai , Jianfeng Li

We report the development and implementation of a hypothesis learning based automated experiment, in which the microscope operating in the autonomous mode identifies the physical laws behind the material's response. Specifically, we explore…

Model-based systems engineering (MBSE) is a methodology that exploits system representation during the entire system life-cycle. The use of formal models has gained momentum in robotics engineering over the past few years. Models play a…

Robotics · Computer Science 2023-09-19 Esther Aguado , Virgilio Gómez , Miguel Hernando , Claudio Rossi , Ricardo Sanz

Years ago Edwards proposed a thermodynamic description of dense granular matter, in which the grains (the `atoms' of the system) interact with inelastic forces. The approach is intriguing but is not justified from first principles, and…

Soft Condensed Matter · Physics 2007-05-23 Hernan A. Makse , Jorge Kurchan

An autonomous experimentation platform in manufacturing is supposedly capable of conducting a sequential search for finding suitable manufacturing conditions by itself or even for discovering new materials with minimal human intervention.…

Machine Learning · Computer Science 2024-10-03 Imtiaz Ahmed , Satish Bukkapatnam , Bhaskar Botcha , Yu Ding

Chain-mapping techniques in combination with the time-dependent density matrix renormalization group are a powerful tool for the simulation of open-system quantum dynamics. For finite-temperature environments, however, this approach suffers…

Quantum Physics · Physics 2019-09-02 Dario Tamascelli , Andrea Smirne , James Lim , Susana F. Huelga , Martin B. Plenio

Autonomous experiments (AEs) are transforming how scientific research is conducted by integrating artificial intelligence with automated experimental platforms. Current AEs primarily focus on the optimization of a predefined target; while…

Machine Learning · Computer Science 2025-08-29 Ralph Bulanadi , Jawad Chowdhury , Funakubo Hiroshi , Maxim Ziatdinov , Rama Vasudevan , Arpan Biswas , Yongtao Liu

Active matter physics and swarm robotics have provided powerful tools for the study and control of ensembles driven by internal sources. At the macroscale, controlling swarms typically utilizes significant memory, processing power, and…

Discovering and optimizing commercially viable materials for clean energy applications typically takes over a decade. Self-driving laboratories that iteratively design, execute, and learn from material science experiments in a fully…

Autonomous materials research systems allow scientists to fail smarter, learn faster, and spend less resources in their studies. As these systems grow in number, capability, and complexity, a new challenge arises - how will they work…

Multiagent Systems · Computer Science 2023-03-21 A. Gilad Kusne , Austin McDannald

We use molecular dynamics simulations to study the dynamics of an ensemble of interacting self-propelled semi-flexible polymers in contact with a thermal bath. Our intention is to model complex systems of biological interest. We find that…

Soft Condensed Matter · Physics 2011-05-06 Davide Loi , Stefano Mossa , Leticia F. Cugliandolo

In this paper, we present a study on how to develop an efficient multiscale simulation strategy for the dynamics of chemically active systems on low-dimensional supports. Such reactions are encountered in a wide variety of situations,…

Computational Physics · Physics 2015-06-04 Giacomo Mazzi , Yannick De Decker , Giovanni Samaey

We review our recent work in the area of autonomous materials research, highlighting the coupling of machine learning methods and models and more problem-aware modeling. We review the general Bayesian framework for closed-loop design…

Materials Science · Physics 2021-03-16 Soojung Baek , Kristofer G. Reyes