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Combinatorial optimization is a promising area for achieving quantum speedup. Quantum approximate optimization algorithm (QAOA) is designed to search for low-energy states of the Ising model, which correspond to near-optimal solutions of…

Quantum Physics · Physics 2025-10-14 Tatsuhiko Shirai , Nozomu Togawa

Hybrid quantum-classical algorithms such as the Quantum Approximate Optimization Algorithm (QAOA) are considered as one of the most encouraging approaches for taking advantage of near-term quantum computers in practical applications. Such…

A combinatorial optimization problem becomes very difficult in situations where the energy landscape is rugged, and the global minimum locates in a narrow region of the configuration space. When using the quantum approximate optimization…

Quantum Physics · Physics 2023-06-22 Zhen-Duo Wang , Pei-Lin Zheng , Biao Wu , Yi Zhang

The quantum approximate optimization algorithm (QAOA) promises to solve classically intractable computational problems in the area of combinatorial optimization. A growing amount of evidence suggests that the originally proposed form of the…

Quantum Physics · Physics 2022-05-04 Michelle Chalupnik , Hans Melo , Yuri Alexeev , Alexey Galda

The Quantum Approximate Optimization Algorithm (QAOA) requires that circuit parameters are determined that allow one to sample from high-quality solutions to combinatorial optimization problems. Such parameters can be obtained using either…

Quantum Physics · Physics 2023-01-11 David Headley , Frank K. Wilhelm

Quantum computing may provide advantage in solving classical optimization problems. One promising algorithm is the quantum approximate optimization algorithm (QAOA). There have been many proposals for improving this algorithm, such as using…

Quantum Physics · Physics 2023-10-17 Vishvesha K. Sridhar , Yanzhu Chen , Bryan Gard , Edwin Barnes , Sophia E. Economou

A key open question in quantum computing is whether quantum algorithms can potentially offer a significant advantage over classical algorithms for tasks of practical interest. Understanding the limits of classical computing in simulating…

Quantum Physics · Physics 2021-06-23 Matija Medvidovic , Giuseppe Carleo

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

We investigate a hybrid quantum-classical algorithm for solving the Maximum Independent Set (MIS) problem on regular graphs, combining the Quantum Approximate Optimization Algorithm (QAOA) with a minimal degree classical greedy algorithm.…

Quantum Physics · Physics 2026-01-30 Elisabeth Wybo , Jami Rönkkö , Olli Hirviniemi , Jernej Rudi Finžgar , Martin Leib

Integer programming (IP) is an NP-hard combinatorial optimization problem that is widely used to represent a diverse set of real-world problems spanning multiple fields, such as finance, engineering, logistics, and operations research. It…

Quantum Physics · Physics 2025-08-20 Kapil Goswami , Peter Schmelcher , Rick Mukherjee

Variational quantum algorithms, such as the Recursive Quantum Approximate Optimization Algorithm (RQAOA), have become increasingly popular, offering promising avenues for employing Noisy Intermediate-Scale Quantum devices to address…

Emerging Technologies · Computer Science 2025-06-04 Shuaiqun Pan , Yash J. Patel , Aneta Neumann , Frank Neumann , Thomas Bäck , Hao Wang

The Quantum Approximate Optimization Algorithm (QAOA) is a prominent quantum algorithm designed to find approximate solutions to combinatorial optimization problems, which are challenging for classical computers. In the current era, where…

The Quantum Approximate Optimization Algorithm (QAOA) has been suggested as a promising candidate for the solution of combinatorial optimization problems. Yet, whether - or under what conditions - it may offer an advantage compared to…

Quantum Physics · Physics 2025-04-14 Vanessa Dehn , Martin Zaefferer , Gerhard Hellstern , Florentin Reiter , Thomas Wellens

Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the…

Quantum Physics · Physics 2024-05-17 Qi-Ming Ding , Yi-Ming Huang , Xiao Yuan

In our pursuit of quantum supremacy during the NISQ era, this research introduces a novel approach rooted in the Quantum Approximate Optimization Algorithm (QAOA) framework to address the Traveling Salesman Problem (TSP). By strategically…

Quantum Physics · Physics 2024-02-29 Mehdi Ramezani , Sadegh Salami , Mehdi Shokhmkar , Morteza Moradi , Alireza Bahrampour

In this work, we compare the performance of the Quantum Approximate Optimization Algorithm (QAOA) with state-of-the-art classical solvers such as Gurobi and MQLib to solve the combinatorial optimization problem MaxCut on 3-regular graphs.…

Quantum Physics · Physics 2024-05-01 Danylo Lykov , Jonathan Wurtz , Cody Poole , Mark Saffman , Tom Noel , Yuri Alexeev

Variational quantum algorithms, which consist of optimal parameterized quantum circuits, are promising for demonstrating quantum advantages in the noisy intermediate-scale quantum (NISQ) era. Apart from classical computational resources,…

Quantum Physics · Physics 2024-12-30 Chen Qian , Wei-Feng Zhuang , Rui-Cheng Guo , Meng-Jun Hu , Dong E. Liu

Understanding the benefits of quantum computing for solving combinatorial optimization problems (COPs) remains an open research question. In this work, we extend and analyze algorithms that solve COPs by recursively shrinking them. The…

The Quantum Approximate Optimization Algorithm (QAOA) is one of the most promising Noisy Intermediate Quantum Algorithms (NISQ) in solving combinatorial optimizations and displays potential over classical heuristic techniques.…

Quantum Physics · Physics 2024-01-18 Arul Rhik Mazumder , Anuvab Sen , Udayon Sen

The Quantum Approximate Optimization Algorithm can naturally be applied to combinatorial search problems on graphs. The quantum circuit has p applications of a unitary operator that respects the locality of the graph. On a graph with…

Quantum Physics · Physics 2020-04-21 Edward Farhi , David Gamarnik , Sam Gutmann