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Nuclei panoptic segmentation supports cancer diagnostics by integrating both semantic and instance segmentation of different cell types to analyze overall tissue structure and individual nuclei in histopathology images. Major challenges…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 Ming Kang , Fung Fung Ting , Raphaël C. -W. Phan , Zongyuan Ge , Chee-Ming Ting

Tumor segmentation plays a critical role in histopathology, but it requires costly, fine-grained image-mask pairs annotated by pathologists. Thus, synthesizing histopathology data to expand the dataset is highly desirable. Previous works…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Hong Liu , Haosen Yang , Evi M. C. Huijben , Mark Schuiveling , Ruisheng Su , Josien P. W. Pluim , Mitko Veta

Segmentation of images holds an important position in the area of image processing. It becomes more important whi le typically dealing with medical images where presurgery and post surgery decisions are required for the purpose of…

Computer Vision and Pattern Recognition · Computer Science 2010-05-25 Mrigank Rajya , Sonal Rewri , Swati Sheoran

Modern histopathological image analysis relies on the segmentation of cell structures to derive quantitative metrics required in biomedical research and clinical diagnostics. State-of-the-art deep learning approaches predominantly apply…

Image and Video Processing · Electrical Eng. & Systems 2022-01-12 Yoav Alon , Huiyu Zhou

Medical image segmentation is crucial for accurate clinical diagnoses, yet it faces challenges such as low contrast between lesions and normal tissues, unclear boundaries, and high variability across patients. Deep learning has improved…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Houze Liu , Tong Zhou , Yanlin Xiang , Aoran Shen , Jiacheng Hu , Junliang Du

Nuclei segmentation is one of the important tasks for whole slide image analysis in digital pathology. With the drastic advance of deep learning, recent deep networks have demonstrated successful performance of the nuclei segmentation task.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Inwan Yoo , Donggeun Yoo , Kyunghyun Paeng

Collecting pixel-level labels for medical datasets can be a laborious and expensive process, and enhancing segmentation performance with a scarcity of labeled data is a crucial challenge. This work introduces AugPaint, a data augmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Xinrong Hu , Yiyu Shi

Separating and labeling each instance of a nucleus (instance-aware segmentation) is the key challenge in segmenting single cell nuclei on fluorescence microscopy images. Deep Neural Networks can learn the implicit transformation of a…

Computer Vision and Pattern Recognition · Computer Science 2021-08-11 Florian Kromp , Lukas Fischer , Eva Bozsaky , Inge Ambros , Wolfgang Doerr , Sabine Taschner-Mandl , Peter Ambros , Allan Hanbury

Nuclear Magnetic Resonance (NMR) spectroscopy is a central characterization method for molecular structure elucidation, yet interpreting NMR spectra to deduce molecular structures remains challenging due to the complexity of spectral data…

Chemical Physics · Physics 2025-07-15 Qingsong Yang , Binglan Wu , Xuwei Liu , Bo Chen , Wei Li , Gen Long , Xin Chen , Mingjun Xiao

Due to cellular heterogeneity, cell nuclei classification, segmentation, and detection from pathological images are challenging tasks. In the last few years, Deep Convolutional Neural Networks (DCNN) approaches have been shown…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Md Zahangir Alom , Chris Yakopcic , Tarek M. Taha , Vijayan K. Asari

Images remain the largest data source in the field of healthcare. But at the same time, they are the most difficult to analyze. More than often, these images are analyzed by human experts such as pathologists and physicians. But due to…

Image and Video Processing · Electrical Eng. & Systems 2021-10-11 Dikshant Sagar

Clustering aims to group similar objects together while separating dissimilar ones apart. Thereafter, structures hidden in data can be identified to help understand data in an unsupervised manner. Traditional clustering methods such as…

Computer Vision and Pattern Recognition · Computer Science 2023-06-23 Jiawei Yao , Enbei Liu , Maham Rashid , Juhua Hu

Osteoclast cell image analysis plays a key role in osteoporosis research, but it typically involves extensive manual image processing and hand annotations by a trained expert. In the last few years, a handful of machine learning approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Sai Kumar Reddy Manne , Brendan Martin , Tyler Roy , Ryan Neilson , Rebecca Peters , Meghana Chillara , Christine W. Lary , Katherine J. Motyl , Michael Wan

Nuclei segmentation is both an important and in some ways ideal task for modern computer vision methods, e.g. convolutional neural networks. While recent developments in theory and open-source software have made these tools easier to…

Computer Vision and Pattern Recognition · Computer Science 2019-01-30 Aarno Oskar Vuola , Saad Ullah Akram , Juho Kannala

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Nucleus segmentation is usually the first step in pathological image analysis tasks. Generalizable nucleus segmentation refers to the problem of training a segmentation model that is robust to domain gaps between the source and target…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Shengcong Chen , Changxing Ding , Dacheng Tao , Hao Chen

Modern deep neural networks can achieve high accuracy when the training distribution and test distribution are identically distributed, but this assumption is frequently violated in practice. When the train and test distributions are…

Machine Learning · Statistics 2020-02-18 Dan Hendrycks , Norman Mu , Ekin D. Cubuk , Barret Zoph , Justin Gilmer , Balaji Lakshminarayanan

The development of medical image segmentation using deep learning can significantly support doctors' diagnoses. Deep learning needs large amounts of data for training, which also requires data augmentation to extend diversity for preventing…

Image and Video Processing · Electrical Eng. & Systems 2023-04-27 Xiaoqing Liu , Kenji Ono , Ryoma Bise

Data augmentation refers to the process of applying a series of transformations or expansions to original data to generate new samples, thereby increasing the diversity and quantity of the data, effectively improving the performance and…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Hao Zhang , Shuaijie Zhang , Renbin Zou

Accurately segmenting and individualizing cells in SEM images is a highly promising technique for elucidating tissue architecture in oncology. While current AI-based methods are effective, errors persist, necessitating time-consuming manual…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Florian Robert , Alexia Calovoulos , Laurent Facq , Fanny Decoeur , Etienne Gontier , Christophe F. Grosset , Baudouin Denis de Senneville