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Neuroimaging measures of the brain's white matter connections can enable the prediction of non-imaging phenotypes, such as demographic and cognitive measures. Existing works have investigated traditional microstructure and connectivity…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Wan Liu , Yuqian Chen , Chuyang Ye , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

Shape plays an important role in computer graphics, offering informative features to convey an object's morphology and functionality. Shape analysis in brain imaging can help interpret structural and functionality correlations of the human…

Computer Vision and Pattern Recognition · Computer Science 2025-04-23 Yui Lo , Yuqian Chen , Dongnan Liu , Wan Liu , Leo Zekelman , Fan Zhang , Yogesh Rathi , Nikos Makris , Alexandra J. Golby , Weidong Cai , Lauren J. O'Donnell

Brain imaging studies have demonstrated that diffusion MRI tractography geometric shape descriptors can inform the study of the brain's white matter pathways and their relationship to brain function. In this work, we investigate the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Yui Lo , Yuqian Chen , Dongnan Liu , Jon Haitz Legarreta , Leo Zekelman , Fan Zhang , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Alexandra J. Golby , Weidong Cai , Lauren J. O'Donnell

White matter tract microstructure has been shown to influence neuropsychological scores of cognitive performance. However, prediction of these scores from white matter tract data has not been attempted. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2022-07-07 Yuqian Chen , Fan Zhang , Chaoyi Zhang , Tengfei Xue , Leo R. Zekelman , Jianzhong He , Yang Song , Nikos Makris , Yogesh Rathi , Alexandra J. Golby , Weidong Cai , Lauren J. O'Donnell

Diffusion magnetic resonance imaging (dMRI) tractography is an advanced imaging technique that enables in vivo mapping of the brain's white matter connections at macro scale. Over the last two decades, the study of brain connectivity using…

Quantitative Methods · Quantitative Biology 2021-04-26 Fan Zhang , Alessandro Daducci , Yong He , Simona Schiavi , Caio Seguin , Robert Smith , Chun-Hung Yeh , Tengda Zhao , Lauren J. O'Donnell

The human brain's white matter (WM) structure is of immense interest to the scientific community. Diffusion MRI gives a powerful tool to describe the brain WM structure noninvasively. To potentially enable monitoring of age-related changes…

Image and Video Processing · Electrical Eng. & Systems 2022-02-09 Hao He , Fan Zhang , Steve Pieper , Nikos Makris , Yogesh Rathi , William Wells , Lauren J. O'Donnell

White matter fiber clustering is an important strategy for white matter parcellation, which enables quantitative analysis of brain connections in health and disease. In combination with expert neuroanatomical labeling, data-driven white…

Computer Vision and Pattern Recognition · Computer Science 2023-07-11 Yuqian Chen , Chaoyi Zhang , Tengfei Xue , Yang Song , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

Fiber tractography on diffusion imaging data offers rich potential for describing white matter pathways in the human brain, but characterizing the spatial organization in these large and complex data sets remains a challenge. We show that…

Methodology · Statistics 2015-06-18 Brian P. Kent , Alessandro Rinaldo , Fang-Cheng Yeh , Timothy Verstynen

Human skill learning requires fine-scale coordination of distributed networks of brain regions that are directly linked to one another by white matter tracts to allow for effective information transmission. Yet how individual differences in…

Neurons and Cognition · Quantitative Biology 2016-10-25 Ari E. Kahn , Marcelo G. Mattar , Jean M. Vettel , Nicholas F. Wymbs , Scott T. Grafton , Danielle S. Bassett

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Bocheng Guo , Jin Wang , Yijie Li , Junyi Wang , Mingyu Gao , Puming Feng , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Shape measures have emerged as promising descriptors of white matter tractography, offering complementary insights into anatomical variability and associations with cognitive and clinical phenotypes. However, conventional methods for…

Image and Video Processing · Electrical Eng. & Systems 2025-10-22 Yui Lo , Yuqian Chen , Dongnan Liu , Leo Zekelman , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Alexandra J. Golby , Fan Zhang , Weidong Cai , Lauren J. O'Donnell

The structure and variability of the brain's connections can be investigated via prediction of non-imaging phenotypes using neural networks. However, known neuroanatomical relationships between input features are generally ignored in…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Yuqian Chen , Fan Zhang , Leo R. Zekelman , Tengfei Xue , Chaoyi Zhang , Yang Song , Nikos Makris , Yogesh Rathi , Weidong Cai , Lauren J. O'Donnell

Tractography from high-dimensional diffusion magnetic resonance imaging (dMRI) data allows brain's structural connectivity analysis. Recent dMRI studies aim to compare connectivity patterns across subject groups and disease populations to…

Neuroimaging-based prediction of neurocognitive measures is valuable for studying how the brain's structure relates to cognitive function. However, the accuracy of prediction using popular linear regression models is relatively low. We…

The relationship between brain connections and non-imaging phenotypes is increasingly studied using deep neural networks. However, the local and global properties of brain white matter networks are often overlooked in convolutional network…

We propose a novel and efficient algorithm to model high-level topological structures of neuronal fibers. Tractography constructs complex neuronal fibers in three dimensions that exhibit the geometry of white matter pathways in the brain.…

Computer Vision and Pattern Recognition · Computer Science 2021-08-04 S. Shailja , Angela Zhang , B. S. Manjunath

The individual course of white matter fiber tracts is an important key for analysis of white matter characteristics in healthy and diseased brains. Uniquely, diffusion-weighted MRI tractography in combination with region-based or…

Computer Vision and Pattern Recognition · Computer Science 2018-08-21 Jakob Wasserthal , Peter Neher , Klaus H. Maier-Hein

The white matter of the brain is organised into axonal bundles that support long-range neural communication. Although diffusion MRI (dMRI) enables detailed mapping of these pathways through tractography, how white matter pathways directly…

Neurons and Cognition · Quantitative Biology 2026-02-24 Yifei Sun , James M. Shine , Robert D. Sanders , Robin F. H. Cash , Sharon L. Naismith , Fernando Calamante , Jinglei Lv

Tractography algorithms are used extensively to delineate white matter structures, by operating on the voxel-wise information generated through the application of diffusion tensor imaging (DTI) or other models to diffusion weighted (DW)…

Quantitative Methods · Quantitative Biology 2024-03-05 Richard G. Carson , Alexander Leemans

The brain structural connectome is generated by a collection of white matter fiber bundles constructed from diffusion weighted MRI (dMRI), acting as highways for neural activity. There has been abundant interest in studying how the…

Methodology · Statistics 2022-11-03 Didong Li , Phuc Nguyen , Zhengwu Zhang , David B Dunson
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