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Molecular Vibe Coding, a paradigm where chemists interact with LLMs to generate executable programs for molecular tasks, has emerged as a flexible alternative to chemical agents with predefined tools, enabling chemists to express…

Computation and Language · Computer Science 2026-05-06 Jiatong Li , Yuxuan Ren , Weida Wang , Changmeng Zheng , Xiao-yong Wei , Qing Li , Yatao Bian

Predictive modelling is vital to guide preventive efforts. Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such survival task efforts, choosing the…

Vision-and-language reasoning requires an understanding of visual concepts, language semantics, and, most importantly, the alignment and relationships between these two modalities. We thus propose the LXMERT (Learning Cross-Modality Encoder…

Computation and Language · Computer Science 2019-12-05 Hao Tan , Mohit Bansal

Model merging provides a scalable alternative to multi-task training by combining specialized finetuned models through parameter arithmetic, enabling efficient deployment without the need for joint training or access to all task data. While…

Machine Learning · Computer Science 2025-10-21 Yifei He , Siqi Zeng , Yuzheng Hu , Rui Yang , Tong Zhang , Han Zhao

There will be a paradigm shift in chemical and biological research, to be enabled by autonomous, closed-loop, real-time self-directed decision-making experimentation. Spectrum-to-structure correlation, which is to elucidate molecular…

Chemical Physics · Physics 2026-01-21 Xinyu Lu , Hao Ma , Hui Li , Jia Li , Yi Rong , Yuqiang Li , Tong Zhu , Guokun Liu , Bin Ren

Developing therapeutics is a lengthy and expensive process that requires the satisfaction of many different criteria, and AI models capable of expediting the process would be invaluable. However, the majority of current AI approaches…

LLM watermarking, which embeds imperceptible yet algorithmically detectable signals in model outputs to identify LLM-generated text, has become crucial in mitigating the potential misuse of large language models. However, the abundance of…

Cryptography and Security · Computer Science 2024-10-29 Leyi Pan , Aiwei Liu , Zhiwei He , Zitian Gao , Xuandong Zhao , Yijian Lu , Binglin Zhou , Shuliang Liu , Xuming Hu , Lijie Wen , Irwin King , Philip S. Yu

Designing de-novo molecules with desired property profiles requires efficient exploration of the vast chemical space ranging from $10^{23}$ to $10^{60}$ possible synthesizable candidates. While various deep generative models have been…

Machine Learning · Computer Science 2025-08-25 Kamran Chitsaz , Roshan Balaji , Quentin Fournier , Nirav Pravinbhai Bhatt , Sarath Chandar

Molecular visualization software has long supported research and education in chemical and structural sciences, but consumer devices constrained to 2D inputs and outputs pose two major challenges: they poorly convey 3D nature, and 3D…

Chemical Physics · Physics 2025-09-05 Luciano A. Abriata

Federated learning has enabled multiple parties to collaboratively train large language models without directly sharing their data (FedLLM). Following this training paradigm, the community has put massive efforts from diverse aspects…

Computation and Language · Computer Science 2024-06-10 Rui Ye , Rui Ge , Xinyu Zhu , Jingyi Chai , Yaxin Du , Yang Liu , Yanfeng Wang , Siheng Chen

Reinforcement learning (RL) solves sequential decision-making problems via a trial-and-error process interacting with the environment. While RL achieves outstanding success in playing complex video games that allow huge trial-and-error,…

Machine Learning · Computer Science 2022-06-22 Fan-Ming Luo , Tian Xu , Hang Lai , Xiong-Hui Chen , Weinan Zhang , Yang Yu

There are many ways to represent a molecule as input to a machine learning model and each is associated with loss and retention of certain kinds of information. In the interest of preserving three-dimensional spatial information, including…

Machine Learning · Computer Science 2019-12-11 Jocelyn Sunseri , David Ryan Koes

Multimodal Entity Linking (MEL) aims to associate textual and visual mentions with entities in a multimodal knowledge graph. Despite its importance, current methods face challenges such as incomplete contextual information, coarse…

Computation and Language · Computer Science 2025-08-25 Fang Wang , Tianwei Yan , Zonghao Yang , Minghao Hu , Jun Zhang , Zhunchen Luo , Xiaoying Bai

Recent advances in large multimodal models have enabled new opportunities in embodied AI, particularly in robotic manipulation. These models have shown strong potential in generalization and reasoning, but achieving reliable and responsible…

Robotics · Computer Science 2025-12-05 Lei Zhang , Ju Dong , Kaixin Bai , Minheng Ni , Zoltan-Csaba Marton , Zhaopeng Chen , Jianwei Zhang

In recent years, Reinforcement Learning (RL), has become a popular field of study as well as a tool for enterprises working on cutting-edge artificial intelligence research. To this end, many researchers have built RL frameworks such as…

Being difficult to scale poses great problems in multi-agent coordination. Multi-agent Reinforcement Learning (MARL) algorithms applied in small-scale multi-agent systems are hard to extend to large-scale ones because the latter is far more…

Artificial Intelligence · Computer Science 2022-02-22 Zixuan Cao , Mengzhi Shi , Zhanbo Zhao , Xiujun Ma

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

Developing new drugs is laborious and costly, demanding extensive time investment. In this paper, we introduce a de-novo drug design strategy, which harnesses the capabilities of language models to devise targeted drugs for specific…

Biomolecules · Quantitative Biology 2025-05-20 Salma J. Ahmed , Emad A. Mohammed

Machine Reading Comprehension (MRC) is an essential task in evaluating natural language understanding. Existing MRC datasets primarily assess specific aspects of reading comprehension (RC), lacking a comprehensive MRC benchmark. To fill…

Computation and Language · Computer Science 2025-03-11 Shengkun Ma , Hao Peng , Lei Hou , Juanzi Li

This paper presents libRoadRunner, an extensible, high-performance, cross-platform, open-source software library for the simulation and analysis of models \ expressed using Systems Biology Markup Language (SBML). SBML is the most widely…

Subcellular Processes · Quantitative Biology 2015-03-04 Endre T. Somogyi , Jean-Marie Bouteiller , James A. Glazier , Matthias König , Kyle Medley , Maciej H. Swat , Herbert M. Sauro
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