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Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch…

Optics · Physics 2025-10-14 Guifeng Li , Chaoyang Gong

Label-free optical microscopy through absorption or scattering spectroscopy provides fundamental insights across biology and materials science, yet its sensitivity remains fundamentally limited by photon shot noise. While recent…

Starting from first principles of wave propagation, we consider a multiple-input multiple-output (MIMO) representation of a communication system between two spatially-continuous volumes. This is the concept of holographic MIMO…

Signal Processing · Electrical Eng. & Systems 2022-09-30 Luca Sanguinetti , Antonio A. D'Amico , Merouane Debbah

Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date…

Applied Physics · Physics 2020-01-08 Yeseul Kim , Hansuek Lee

Integrating femtosecond (fs) lasers to electron microscopies has enabled direct imaging of transient structures and morphologies of materials in real time and space, namely, ultrafast electron microscopy (UEM). Here we report the…

Roughly half of a cells proteins are located at or near the plasma membrane. In this restricted space the cell senses its environment, signals to its neighbors and ex-changes cargo through exo- and endocytotic mechanisms. Ligands bind to…

Biological Physics · Physics 2019-10-02 Martin Oheim , Adi Salomon , Adam Weissman , Maia Brunstein , Ute Becherer

Surface electromyography (sEMG) signals show promise for effective human-machine interfaces, particularly in rehabilitation and prosthetics. However, challenges remain in developing systems that respond quickly to user intent, produce…

Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are…

The contemporary superconductive electronics is widely using planar circuits with micrometer-scale elements for a variety of applications. With the rise of complexity of a circuit and increased number of its components, a simple impedance…

Applied Physics · Physics 2019-07-24 A. Karpov , A. P. Zhuravel , A. S. Averkin , V. I. Chichkov , A. V. Ustinov

Gesture recognition based on surface electromyography (sEMG) has been gaining importance in many 3D Interactive Scenes. However, sEMG is easily influenced by various forms of noise in real-world environments, leading to challenges in…

Signal Processing · Electrical Eng. & Systems 2024-04-18 Weiyu Guo , Ziyue Qiao , Ying Sun , Hui Xiong

Dynamic control of metamaterials and metasurfaces is crucial for many photonic technologies, such as flat lenses, displays, augmented reality devices, and beam steering, to name a few. The dynamic response is typically achieved by…

Signal transduction and cell function are governed by the spatiotemporal organization of membrane-associated molecules. Despite significant advances in visualizing molecular distributions by 3D light microscopy, cell biologists still have…

Quantitative Methods · Quantitative Biology 2023-04-14 Felix Y. Zhou , Andrew Weems , Gabriel M. Gihana , Bingying Chen , Bo-Jui Chang , Meghan Driscoll , Gaudenz Danuser

Quantitative phase microscopy (QPM) enables label-free measurement of local optical path length variations, providing critical insight into the structure and dynamics of transparent biological specimens. Here, a highly sensitive lateral…

Primary neuronal cultures have been widely used to study neuronal morphology, neurophysiology, neurodegenerative processes, and molecular mechanism of synaptic plasticity underlying learning and memory. Yet, the unique behavioral properties…

Image and Video Processing · Electrical Eng. & Systems 2020-08-04 Mikhail E. Kandel , Eunjae Kim , Young Jae Lee , Gregory Tracy , Hee Jung Chung , Gabriel Popescu

Magnetic Resonance Elastography (MRE) has become an essential tool in assessing the mechanical properties of soft tissues in-vivo, prompting significant progress in new inversion algorithms. This creates a need for a benchmarking framework…

Numerical Analysis · Mathematics 2026-04-06 Yashasvi Verma , Jakob Schattenfroh , Ingolf Sack , Silvia Budday , Paul Steinmann , Luca Heltai

Intelligent reflecting surfaces (IRS) are valuable tools for enhancing the intelligence of the propagation environment. They have the ability to direct EM Waves to a specific user through beamforming. A significant number of passive…

Applied Physics · Physics 2024-05-13 Mohammadreza Jahangiri , Hossein Soleimani , Mohammad Soleimani

Over recent decades, lipid membranes have become standard models for examining the biophysics and biochemistry of cell membranes. Interrogation of lipid domains within biomembranes is generally done with fluorescence microscopy via…

Biological Physics · Physics 2018-03-30 Stephen H. Donaldson , Hilton B. de Aguiar

Deciphering ion channel activity and signaling interactions within cells is one of the key tasks of neuroscience. Currently, measuring this electrophysiological activity is done using patch-clamp1-4 or voltage-sensitive imaging5-8.…

Biological Physics · Physics 2023-12-29 Qing-Yue Li , Pin-Tian Lyu , Bin Kang , Hong-Yuan Chen , Jing-Juan Xu

Due to the increasing demand of capacity in wireless cellular networks, the small cells such as pico and femto cells are becoming more popular to enjoy a spatial reuse gain, and thus cells with different sizes are expected to coexist in a…

Networking and Internet Architecture · Computer Science 2011-05-05 Kyuho Son , Soohwan Lee , Yung Yi , Song Chong

Semantic image synthesis (SIS) is a task to generate realistic images corresponding to semantic maps (labels). However, in real-world applications, SIS often encounters noisy user inputs. To address this, we propose Stochastic Conditional…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Juyeon Ko , Inho Kong , Dogyun Park , Hyunwoo J. Kim