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Epilepsy and psychogenic non-epileptic seizures often present with similar seizure-like manifestations but require fundamentally different management strategies. Misdiagnosis is common and can lead to prolonged diagnostic delays,…

Computation and Language · Computer Science 2026-03-31 Shuang Zhou , Kai Yu , Zaifu Zhan , Huixue Zhou , Min Zeng , Feng Xie , Zhiyi Sha , Rui Zhang

Epilepsy represents the most prevalent neurological disease in the world. One-third of people suffering from mesial temporal lobe epilepsy (MTLE) exhibit drug resistance, urging the need to develop new treatments. A key part in anti-seizure…

While Deep Learning (DL) is often considered the state-of-the art for Artificial Intelligence-based medical decision support, it remains sparsely implemented in clinical practice and poorly trusted by clinicians due to insufficient…

Machine Learning · Computer Science 2020-12-23 Valentin Gabeff , Tomas Teijeiro , Marina Zapater , Leila Cammoun , Sylvain Rheims , Philippe Ryvlin , David Atienza

Seizure detection algorithms must discriminate abnormal neuronal activity associated with a seizure from normal neural activity in a variety of conditions. Our approach is to seek spatiotemporal waveforms with distinct morphology in…

Machine Learning · Computer Science 2021-08-16 Carlos H. Mendoza-Cardenas , Austin J. Brockmeier

Epilepsy affects more than 50 million people worldwide, making it one of the world's most prevalent neurological diseases. The main symptom of epilepsy is seizures, which occur abruptly and can cause serious injury or death. The ability to…

Signal Processing · Electrical Eng. & Systems 2024-02-06 Zakary Georgis-Yap , Milos R. Popovic , Shehroz S. Khan

Electroencephalogram (EEG) signals are effective tools towards seizure analysis where one of the most important challenges is accurate detection of seizure events and brain regions in which seizure happens or initiates. However, all…

Machine Learning · Computer Science 2023-01-18 Thi Kieu Khanh Ho , Narges Armanfard

Epileptic seizure detection and classification in clinical electroencephalogram data still is a challenge, and only low sensitivity with a high rate of false positives has been achieved with commercially available seizure detection tools,…

Signal Processing · Electrical Eng. & Systems 2020-07-14 Tomas Iesmantas , Robertas Alzbutas

Accurate prediction of epileptic seizures could prove critical for improving patient safety and quality of life in drug-resistant epilepsy. Although deep learning-based approaches have shown promising seizure prediction performance using…

Signal Processing · Electrical Eng. & Systems 2024-12-31 Petros Koutsouvelis , Bartlomiej Chybowski , Alfredo Gonzalez-Sulser , Shima Abdullateef , Javier Escudero

Focal seizures are episodes of pathological brain activity that appear to arise from a localised area of the brain. The onset patterns of focal seizure activity have been studied intensively, and they have largely been distinguished into…

Neurons and Cognition · Quantitative Biology 2017-05-08 Yujiang Wang , Andrew J Trevelyan , Antonio Valentin , Gonzalo Alarcon , Peter N Taylor , Marcus Kaiser

Background and Objectives: Many biological processes are modulated by rhythms on circadian and multidien timescales. In focal epilepsy, various seizure features, such as spread and duration, can change from one seizure to the next within…

Deep learning is advancing EEG processing for automated epileptic seizure detection and onset zone localization, yet its performance relies heavily on high-quality annotated training data. However, scalp EEG is susceptible to high noise…

Signal Processing · Electrical Eng. & Systems 2026-01-06 Deeksha M. Shama , Archana Venkataraman

Epilepsy is a common, chronic neurological disorder characterized by recurrent seizures caused by sudden bursts of abnormal electrical activity in the brain. Seizures can often be unpredictable, leading to uncertainty and anxiety for people…

Human-Computer Interaction · Computer Science 2026-04-21 Berenika Ewart-James , Matthew Wragg , Nawid Keshtmand , Amberly Brigden , Paul Marshall , Raul Santos-Rodriguez

Epileptic seizure detection from EEG signals remains challenging due to the high dimensionality and nonlinear, potentially stochastic, dynamics of neural activity. In this work, we investigate whether features derived from topological data…

Machine Learning · Computer Science 2026-04-15 Sunia Tanweer , Narayan Puthanmadam Subramaniyam , Firas A. Khasawneh

Epilepsy is one of the most occurring neurological disease globally emerged back in 4000 BC. It is affecting around 50 million people of all ages these days. The trait of this disease is recurrent seizures. In the past few decades, the…

Machine Learning · Computer Science 2021-11-08 Virender Ranga , Shivam Gupta , Jyoti Meena , Priyansh Agrawal

Accurately localizing the brain regions that triggers seizures and predicting whether a patient will be seizure-free after surgery are vital for surgical planning and patient management in drug-resistant epilepsy.…

Signal Processing · Electrical Eng. & Systems 2025-05-30 Syeda Abeera Amir , Artur Agaronyan , William Gaillard , Chima Oluigbo , Syed Muhammad Anwar

Hyperdimensional computing is a promising novel paradigm for low-power embedded machine learning. It has been applied on different biomedical applications, and particularly on epileptic seizure detection. Unfortunately, due to differences…

Signal Processing · Electrical Eng. & Systems 2021-12-20 Una Pale , Tomas Teijeiro , David Atienza

Epilepsy or the occurrence of epileptic seizures, is one of the world's most well-known neurological disorders affecting millions of people. Seizures mostly occur due to non-coordinated electrical discharges in the human brain and may cause…

Machine Learning · Computer Science 2023-03-14 Hitesh Raju , Ankit Sharma , Aoife Smeaton , Alan F. Smeaton

Stereo-electroencephalography (SEEG) is an invasive technique to implant depth electrodes and collect data for pre-surgery evaluation. Visual inspection of signals recorded from hundreds of channels is time consuming and inefficient. We…

Signal Processing · Electrical Eng. & Systems 2026-04-20 Saeed Hashemi , Genchang Peng , Mehrdad Nourani , Omar Nofal , Jay Harvey

Epilepsy is a neurological condition such that it affects the brain and the nervous system. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of…

Signal Processing · Electrical Eng. & Systems 2018-07-30 Asmaa Hamad , Aboul Ella Hassanien , Aly A. Fahmy , Essam H. Houssein

In this paper, we introduce SeizNet, a closed-loop system for predicting epileptic seizures through the use of Deep Learning (DL) method and implantable sensor networks. While pharmacological treatment is effective for some epilepsy…

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