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Metagenomic binning aims to cluster DNA fragments from mixed microbial samples into their respective genomes, a critical step for downstream analyses of microbial communities. Existing methods rely on deterministic representations, such as…

Machine Learning · Computer Science 2025-10-01 Abdulkadir Celikkanat , Andres R. Masegosa , Mads Albertsen , Thomas D. Nielsen

This paper considers the problems of modeling and predicting a long-term and ``blurry'' relapse that occurs after a medical act, such as a surgery. The relapse is observed only indirectly, in a ``blurry'' fashion, through longitudinal…

Machine Learning · Computer Science 2020-07-28 Anastasiia Kabeshova , Yiyang Yu , Bertrand Lukacs , Emmanuel Bacry , Stéphane Gaïffas

Background: The inception of next generations sequencing technologies have exponentially increased the volume of biological sequence data. Protein sequences, being quoted as the `language of life', has been analyzed for a multitude of…

Quantitative Methods · Quantitative Biology 2020-12-08 Nabil Ibtehaz , S. M. Shakhawat Hossain Sourav , Md. Shamsuzzoha Bayzid , M. Sohel Rahman

We consider the communication complexity of the Hamming distance of two strings. Bille et al. [SPIRE 2018] considered the communication complexity of the longest common prefix (LCP) problem in the setting where the two parties have their…

Data Structures and Algorithms · Computer Science 2021-04-02 Shiori Mitsuya , Yuto Nakashima , Shunsuke Inenaga , Hideo Bannai , Masayuki Takeda

Differences in the regional substitution patterns in the human genome created patterns of large-scale variation of base composition known as genomic isochores. To gain insight into the origin of the genomic isochores we develop a maximum…

Statistical Mechanics · Physics 2007-05-23 Peter F. Arndt , Dmitri A. Petrov , Terence Hwa

In this paper, we study the pattern occurrence in $k$-ary words. We prove an explicit upper bound on the number of $k$-ary words avoiding any given pattern using a random walk argument. Additionally, we reproduce several already known…

Combinatorics · Mathematics 2022-12-22 Toufik Mansour , Reza Rastegar

The X chromosome is present as a single copy in the heterogametic sex, and this hemizygosity is expected to drive unusual patterns of evolution on the X relative to the autosomes. For example, the hemizgosity of the X may lead to a lower…

Populations and Evolution · Quantitative Biology 2015-03-20 Melek A. Kayserili , Dave T. Gerrard , Pavel Tomancak , Alex T. Kalinka

We have analyzed gene expression data from 3 different kinds of samples: normal human tissues, human cancer cell lines and leukemic cells from lymphoid and myeloid leukemia pediatric patients. We have searched for genes that are over…

Tissues and Organs · Quantitative Biology 2009-11-11 Joseph Lotem , Dvir Netanely , Eytan Domany , Leo Sachs

Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of…

Other Quantitative Biology · Quantitative Biology 2019-10-28 Ivan Savelev , Max Myakishev-Rempel

By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on…

Genomics · Quantitative Biology 2008-03-11 Rutger Hermsen , Pieter Rein ten Wolde , Sarah Teichmann

We present a new approach to the problem of enumerating permutations of length n that avoid a fixed consecutive pattern of length m. We use this idea to give explicit upper and lower bounds on the number of permutations avoiding a pattern…

Combinatorics · Mathematics 2012-08-29 Guillem Perarnau

The ICTV develops, refines and maintains a universal virus taxonomy; Order is the highest taxon in the branching hierarchy of recognised viral taxa. Historically, ICTV (sub)committees have classified viruses on the basis of morphological…

Genomics · Quantitative Biology 2018-09-12 T. Wang , M. Herbster , I. S. Mian

Inversions, also sometimes called reversals, are a major contributor to variation among bacterial genomes, with studies suggesting that those involving small numbers of regions are more likely than larger inversions. Deletions may arise in…

Rings and Algebras · Mathematics 2023-07-11 Chad Clark , Julius Jonušas , James D. Mitchell , Andrew Francis

In a recent preprint, Mike Cummings showed that the smooth components of suitably parametrized Springer fibers are in bijection with contracted, fully reduced Pl\"ucker degree-two $\mathfrak{sl}_r$-webs of standard type and that are…

Combinatorics · Mathematics 2026-03-19 Jessica Striker , Bridget Eileen Tenner

We derive theoretical upper and lower bounds on the maximum size of DNA codes of length n with constant GC-content w and minimum Hamming distance d, both with and without the additional constraint that the minimum Hamming distance between…

Combinatorics · Mathematics 2007-05-23 Oliver D. King

Ensembl's human non-coding and protein coding genes are used to automatically find DNA pattern motifs. The Backus-Naur form (BNF) grammar for regular expressions (RE) is used by genetic programming to ensure the generated strings are legal.…

Biomolecules · Quantitative Biology 2010-02-02 W. B. Langdon , Olivia Sanchez Graillet , A. P. Harrison

Zipf's law of abbreviation, the tendency of more frequent words to be shorter, is one of the most solid candidates for a linguistic universal, in the sense that it has the potential for being exceptionless or with a number of exceptions…

Computation and Language · Computer Science 2023-10-13 Sonia Petrini , Antoni Casas-i-Muñoz , Jordi Cluet-i-Martinell , Mengxue Wang , Chris Bentz , Ramon Ferrer-i-Cancho

Mutually Uncorrelated (MU) codes are a class of codes in which no proper prefix of one codeword is a suffix of another codeword. These codes were originally studied for synchronization purposes and recently, Yazdi et al. showed their…

Information Theory · Computer Science 2018-04-17 Maya Levy , Eitan Yaakobi

Vincular or dashed patterns resemble classical patterns except that some of the letters within an occurrence are required to be adjacent. We prove several infinite families of Wilf-equivalences for k-ary words involving vincular patterns…

Combinatorics · Mathematics 2014-03-11 Toufik Mansour , Mark Shattuck

Significant fraction (about 98.5% in humans, 24% in microbe Rickettsia prowazekii) of most animal genomes is non-coding DNA. Although recent studies established functions of its certain portions, it remains genomic dark matter. The paper…

Genomics · Quantitative Biology 2007-05-23 Mark Ya. Azbel
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