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Large language models (LLMs) have achieved remarkable outcomes in complex problems, including math, coding, and analyzing large amounts of scientific reports. Yet, few works have explored the potential of LLMs in quantum computing. The most…

Quantum Physics · Physics 2026-01-28 Linus Jern , Valter Uotila , Cong Yu , Bo Zhao

In structure-based virtual screening, it is often necessary to evaluate the binding free energy of protein-ligand complexes by considering not only molecular conformations but also how these structures shift and rotate in space. The number…

Quantum Physics · Physics 2025-07-25 Pei-Kun Yang

Variational Quantum Eigensolver (VQE) provides a powerful solution for approximating molecular ground state energies by combining quantum circuits and classical computers. However, estimating probabilistic outcomes on quantum hardware…

Quantum Physics · Physics 2024-05-07 Senwei Liang , Linghua Zhu , Xiaolin Liu , Chao Yang , Xiaosong Li

This paper introduces a quantum framework for addressing reinforcement learning (RL) tasks, grounded in the quantum principles and leveraging a fully quantum model of the classical Markov decision process (MDP). By employing quantum…

Quantum Physics · Physics 2026-04-23 Thet Htar Su , Shaswot Shresthamali , Masaaki Kondo

Parameterised quantum circuit (PQC) based Quantum Reinforcement Learning (QRL) has emerged as a promising paradigm at the intersection of quantum computing and reinforcement learning (RL). By design, PQCs create hybrid quantum-classical…

Quantum Physics · Physics 2025-11-24 Javier Lazaro , Juan-Ignacio Vazquez , Pablo Garcia-Bringas

Deep reinforcement learning has been recognized as an efficient technique to design optimal strategies for different complex systems without prior knowledge of the control landscape. To achieve a fast and precise control for quantum…

Quantum Physics · Physics 2021-01-05 Hailan Ma , Daoyi Dong , Steven X. Ding , Chunlin Chen

Quantum computing requires the optimization of control pulses to achieve high-fidelity quantum gates. We propose a machine learning-based protocol to address the challenges of evaluating gradients and modeling complex system dynamics. By…

Quantum Physics · Physics 2026-01-27 Paul Surrey , Julian D. Teske , Tobias Hangleiter , Hendrik Bluhm , Pascal Cerfontaine

With the development of experimental quantum technology, quantum control has attracted increasing attention due to the realization of controllable artificial quantum systems. However, because quantum-mechanical systems are often too…

Quantum Physics · Physics 2022-12-22 Zhikang Wang

Learning quantum states is a crucial task for realizing quantum information technology. Recently, neural approaches have emerged as promising methods for learning quantum states. We propose a meta-learning model that utilizes reinforcement…

Quantum Physics · Physics 2025-08-06 Jeongwoo Jae , Jeonghoon Hong , Jinho Choo , Yeong-Dae Kwon

Quantum computing has promised significant improvement in solving difficult computational tasks over classical computers. Designing quantum circuits for practical use, however, is not a trivial objective and requires expert-level knowledge.…

Quantum Physics · Physics 2021-12-14 Esther Ye , Samuel Yen-Chi Chen

We present a new platform facilitating quantum logic control of polar molecular ions in a segmented ring ion trap, paving the way for precision measurements. This approach focuses on achieving near-unity state preparation and detection, as…

Atomic Physics · Physics 2023-07-27 Yan Zhou , Joshua O. Island , Matt Grau

Reinforcement learning (RL) provides a principled framework for decision-making in partially observable environments, which can be modeled as Markov decision processes and compactly represented through dynamic decision Bayesian networks.…

Quantum Physics · Physics 2025-07-25 Gilberto Cunha , Alexandra Ramôa , André Sequeira , Michael de Oliveira , Luís Barbosa

We study non-classical pathways and quantum interference in enhanced ionisation of diatomic molecules in strong laser fields using machine learning techniques. Quantum interference provides a bridge, which facilitates intramolecular…

We introduce machine learning models of quantum mechanical observables of atoms in molecules. Instant out-of-sample predictions for proton and carbon nuclear chemical shifts, atomic core level excitations, and forces on atoms reach…

Chemical Physics · Physics 2015-08-26 Matthias Rupp , Raghunathan Ramakrishnan , O. Anatole von Lilienfeld

The Research & Development (R&D) phase of drug development is a lengthy and costly process. To revolutionize this process, we introduce our new concept QMLS to shorten the whole R&D phase to three to six months and decrease the cost to…

Biomolecules · Quantitative Biology 2024-09-06 Yifan Zhou , Yan Shing Liang , Yew Kee Wong , Haichuan Qiu , Yu Xi Wu , Bin He

Quantum Machine Learning(QML) is developed by combining quantum mechanics principles with classical machine learning techniques in a hybrid framework that can give faster, exponential, more efficient power of quantum computing with the data…

Quantum Physics · Physics 2026-01-27 Pallab Biswas , Tamal Maity

We present a framework, which we call Molecule Deep $Q$-Networks (MolDQN), for molecule optimization by combining domain knowledge of chemistry and state-of-the-art reinforcement learning techniques (double $Q$-learning and randomized value…

Machine Learning · Computer Science 2020-06-22 Zhenpeng Zhou , Steven Kearnes , Li Li , Richard N. Zare , Patrick Riley

Quantum control has been of increasing interest in recent years, e.g. for tasks like state initialization and stabilization. Feedback-based strategies are particularly powerful, but also hard to find, due to the exponentially increased…

Quantum Physics · Physics 2022-06-30 Riccardo Porotti , Antoine Essig , Benjamin Huard , Florian Marquardt

Quantum algorithm design plays a crucial role in exploiting the computational advantage of quantum devices. Here we develop a deep-reinforcement-learning based approach for quantum adiabatic algorithm design. Our approach is generically…

Quantum Physics · Physics 2020-05-20 Jian Lin , Zhong Yuan Lai , Xiaopeng Li

High-fidelity control of one- and two-qubit gates past the error correction threshold is an essential ingredient for scalable quantum computing. We present a reinforcement learning (RL) approach to find entangling protocols for…

Quantum Physics · Physics 2025-08-21 Mohammad Abedi , Markus Schmitt
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