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Reinforcement learning has recently been explored to improve text-to-image generation, yet applying existing GRPO algorithms to autoregressive (AR) image models remains challenging. The instability of the training process easily disrupts…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Xiaoxiao Ma , Haibo Qiu , Guohui Zhang , Zhixiong Zeng , Siqi Yang , Lin Ma , Feng Zhao

Generative molecular optimization aims to design molecules with properties surpassing those of existing compounds. However, such candidates are rare and expensive to evaluate, yielding sample efficiency essential. Additionally, surrogate…

Machine learning has the potential to automate molecular design and drastically accelerate the discovery of new functional compounds. Towards this goal, generative models and reinforcement learning (RL) using string and graph…

Machine Learning · Computer Science 2022-02-02 Daniel Flam-Shepherd , Alexander Zhigalin , Alán Aspuru-Guzik

Recent work on enhancing the reasoning abilities of large language models (LLMs) has introduced explicit length control as a means of constraining computational cost while preserving accuracy. However, existing approaches rely on…

Computation and Language · Computer Science 2025-08-13 Hasan Abed Al Kader Hammoud , Kumail Alhamoud , Abed Hammoud , Elie Bou-Zeid , Marzyeh Ghassemi , Bernard Ghanem

Computer-aided design of molecules has the potential to disrupt the field of drug and material discovery. Machine learning, and deep learning, in particular, have been topics where the field has been developing at a rapid pace.…

Machine Learning · Computer Science 2022-08-08 Luca A. Thiede , Mario Krenn , AkshatKumar Nigam , Alan Aspuru-Guzik

Retrieval-Augmented Generation (RAG) enhances coding tasks by incorporating retrieved code examples into prompts. However, lengthy prompts, often exceeding tens of thousands of tokens, introduce challenges related to limited context windows…

Software Engineering · Computer Science 2026-04-13 Pengfei He , Shaowei Wang , Tse-Hsun Chen

Reward shaping is a technique in reinforcement learning that addresses the sparse-reward problem by providing more frequent and informative rewards. We introduce a self-adaptive and highly efficient reward shaping mechanism that…

Machine Learning · Computer Science 2025-03-03 Haozhe Ma , Zhengding Luo , Thanh Vinh Vo , Kuankuan Sima , Tze-Yun Leong

Generative modeling has recently shown great promise in computer vision, but it has mostly focused on synthesizing visually realistic images. In this paper, motivated by multi-task learning of shareable feature representations, we consider…

Computer Vision and Pattern Recognition · Computer Science 2021-06-28 Zhipeng Bao , Martial Hebert , Yu-Xiong Wang

Exploration is essential in reinforcement learning as an agent relies on trial and error to learn an optimal policy. However, when rewards are sparse, naive exploration strategies, like noise injection, are often insufficient. Intrinsic…

Machine Learning · Computer Science 2026-01-30 Minjae Cho , Huy Trong Tran

While Large Language Models (LLMs) excel at generating human-like text, aligning their outputs with complex, qualitative goals like pedagogical soundness remains a significant challenge. Standard reinforcement learning techniques often rely…

Computation and Language · Computer Science 2025-09-17 Francesco Pappone , Ruggero Marino Lazzaroni , Federico Califano , Niccolò Gentile , Roberto Marras

Designing molecules with specific properties is a long-lasting research problem and is central to advancing crucial domains such as drug discovery and material science. Recent advances in deep graph generative models treat molecule design…

Machine Learning · Computer Science 2022-03-02 Yuanqi Du , Xiaojie Guo , Amarda Shehu , Liang Zhao

Reinforcement learning often needs to deal with the exponential growth of states and actions when exploring optimal control in high-dimensional spaces (often known as the curse of dimensionality). In this work, we address this issue by…

Machine Learning · Computer Science 2023-06-23 Yining Li , Peizhong Ju , Ness Shroff

Efficient exploration is important for reinforcement learners to achieve high rewards. In multi-agent systems, coordinated exploration and behaviour is critical for agents to jointly achieve optimal outcomes. In this paper, we introduce a…

Several generative models with elaborate training and sampling procedures have been proposed to accelerate structure-based drug design (SBDD); however, their empirical performance turns out to be suboptimal. We seek to better understand…

Machine Learning · Computer Science 2025-03-04 Rafał Karczewski , Samuel Kaski , Markus Heinonen , Vikas Garg

Intent detection, a critical component in task-oriented dialogue (TOD) systems, faces significant challenges in adapting to the rapid influx of integrable tools with complex interrelationships. Existing approaches, such as zero-shot…

Computation and Language · Computer Science 2025-04-22 Zihao Feng , Xiaoxue Wang , Ziwei Bai , Donghang Su , Bowen Wu , Qun Yu , Baoxun Wang

Recent advances in denoising diffusion models have enabled rapid generation of optimized structures for topology optimization. However, these models often rely on surrogate predictors to enforce physical constraints, which may fail to…

Machine Learning · Computer Science 2025-08-05 Euihyun Kim , Keun Park , Yeoneung Kim

Due to the vast design space of molecules, generating molecules conditioned on a specific sub-structure relevant to a particular function or therapeutic target is a crucial task in computer-aided drug design. Existing works mainly focus on…

Biomolecules · Quantitative Biology 2024-12-24 Qi Zhengyang , Liu Zijing , Zhang Jiying , Cao He , Li Yu

Large Language Models (LLMs) empowered with Tool-Integrated Reasoning (TIR) can iteratively plan, call external tools, and integrate returned information to solve complex, long-horizon reasoning tasks. Agentic Reinforcement Learning…

Computation and Language · Computer Science 2026-01-21 Jianghao Su , Xia Zeng , Luhui Liu , Chao Luo , Ye Chen , Zhuoran Zhuang

We consider the situation where we have a limited number of denoising steps, i.e., of evaluations of a diffusion model. We show that two parallel processors or samplers under such limitation can improve the quality of the sampled image.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Pedro Cisneros-Velarde

Group Relative Policy Optimization (GRPO) has been shown to be an effective algorithm when an accurate reward model is available. However, such a highly reliable reward model is not available in many real-world tasks. In this paper, we…

Machine Learning · Computer Science 2026-01-12 Yuki Ichihara , Yuu Jinnai , Tetsuro Morimura , Mitsuki Sakamoto , Ryota Mitsuhashi , Eiji Uchibe