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We describe a novel method for training high-quality image denoising models based on unorganized collections of corrupted images. The training does not need access to clean reference images, or explicit pairs of corrupted images, and can…

Machine Learning · Computer Science 2019-10-29 Samuli Laine , Tero Karras , Jaakko Lehtinen , Timo Aila

As a hybrid imaging technology, photoacoustic microscopy (PAM) imaging suffers from noise due to the maximum permissible exposure of laser intensity, attenuation of ultrasound in the tissue, and the inherent noise of the transducer.…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Da He , Jiasheng Zhou , Xiaoyu Shang , Jiajia Luo , Sung-Liang Chen

Constructing of molecular structural models from Cryo-Electron Microscopy (Cryo-EM) density volumes is the critical last step of structure determination by Cryo-EM technologies. Methods have evolved from manual construction by structural…

Machine Learning · Computer Science 2019-02-13 Kui Xu , Zhe Wang , Jiangping Shi , Hongsheng Li , Qiangfeng Cliff Zhang

Foundation models pre-trained on large-scale natural image datasets offer a powerful paradigm for medical image segmentation. However, effectively transferring their learned representations for precise clinical applications remains a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Haoyue Li , Yifan Gao , Feng Yuan , Xiaosong Wang , Xin Gao

Lacking rich and realistic data, learned single image denoising algorithms generalize poorly to real raw images that do not resemble the data used for training. Although the problem can be alleviated by the heteroscedastic Gaussian model…

Image and Video Processing · Electrical Eng. & Systems 2020-04-10 Kaixuan Wei , Ying Fu , Jiaolong Yang , Hua Huang

Depth perception is considered an invaluable source of information for various vision tasks. However, depth maps acquired using consumer-level sensors still suffer from non-negligible noise. This fact has recently motivated researchers to…

Image denoising is an important low-level computer vision task, which aims to reconstruct a noise-free and high-quality image from a noisy image. With the development of deep learning, convolutional neural network (CNN) has been gradually…

Computer Vision and Pattern Recognition · Computer Science 2022-05-17 Chao Yao , Shuo Jin , Meiqin Liu , Xiaojuan Ban

Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…

Biomolecules · Quantitative Biology 2021-06-29 Kai Yi , Jianye Pang , Yungeng Zhang , Xiangrui Zeng , Min Xu

Purpose: Depth estimation in robotic surgery is vital in 3D reconstruction, surgical navigation and augmented reality visualization. Although the foundation model exhibits outstanding performance in many vision tasks, including depth…

Computer Vision and Pattern Recognition · Computer Science 2024-01-15 Beilei Cui , Mobarakol Islam , Long Bai , Hongliang Ren

Image denoising is a fundamental challenge in computer vision, with applications in photography and medical imaging. While deep learning-based methods have shown remarkable success, their reliance on specific noise distributions limits…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Dongjin Kim , Jaekyun Ko , Muhammad Kashif Ali , Tae Hyun Kim

In generative modeling, tokenization simplifies complex data into compact, structured representations, creating a more efficient, learnable space. For high-dimensional visual data, it reduces redundancy and emphasizes key features for…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Long Zhao , Sanghyun Woo , Ziyu Wan , Yandong Li , Han Zhang , Boqing Gong , Hartwig Adam , Xuhui Jia , Ting Liu

When capturing and storing images, devices inevitably introduce noise. Reducing this noise is a critical task called image denoising. Deep learning has become the de facto method for image denoising, especially with the emergence of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Haoyu Chen , Jinjin Gu , Yihao Liu , Salma Abdel Magid , Chao Dong , Qiong Wang , Hanspeter Pfister , Lei Zhu

A wide variety of image denoising methods are available now. However, the performance of a denoising algorithm often depends on individual input noisy images as well as its parameter setting. In this paper, we present a no-reference image…

Image and Video Processing · Electrical Eng. & Systems 2018-10-16 Si Lu

Most existing Image Restoration (IR) models are task-specific, which can not be generalized to different degradation operators. In this work, we propose the Denoising Diffusion Null-Space Model (DDNM), a novel zero-shot framework for…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Yinhuai Wang , Jiwen Yu , Jian Zhang

Single-particle cryo-electron microscopy (cryo-EM) has become a cornerstone of structural biology, enabling near-atomic resolution analysis of macromolecules through advanced computational methods. However, the development of cryo-EM…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Runmin Jiang , Genpei Zhang , Yuntian Yang , Siqi Wu , Minhao Wu , Wanyue Feng , Yizhou Zhao , Xi Xiao , Xiao Wang , Tianyang Wang , Xingjian Li , Muyuan Chen , Min Xu

Document denoising is considered one of the most challenging tasks in computer vision. There exist millions of documents that are still to be digitized, but problems like document degradation due to natural and man-made factors make this…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Yashowardhan Shinde , Kishore Kulkarni , Sachin Kuberkar

Medical image denoising is considered among the most challenging vision tasks. Despite the real-world implications, existing denoising methods have notable drawbacks as they often generate visual artifacts when applied to heterogeneous…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 S M A Sharif , Rizwan Ali Naqvi , Woong-Kee Loh

We propose a data-dependent denoising procedure to restore noisy images. Different from existing denoising algorithms which search for patches from either the noisy image or a generic database, the new algorithm finds patches from a…

Computer Vision and Pattern Recognition · Computer Science 2015-06-22 Enming Luo , Stanley H. Chan , Truong Q. Nguyen

Fully supervised deep-learning based denoisers are currently the most performing image denoising solutions. However, they require clean reference images. When the target noise is complex, e.g. composed of an unknown mixture of primary…

Image and Video Processing · Electrical Eng. & Systems 2020-08-03 Florian Lemarchand , Erwan Nogues , Maxime Pelcat

Image denoising is a classical problem in low level computer vision. Model-based optimization methods and deep learning approaches have been the two main strategies for solving the problem. Model-based optimization methods are flexible for…

Computer Vision and Pattern Recognition · Computer Science 2018-12-31 Chang Liu , Zhaowei Shang , Anyong Qin