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Cryo-electron microscopy (cryo-EM) has become a major experimental technique to determine the structures of large protein complexes and molecular assemblies, as evidenced by the 2017 Nobel Prize. Although cryo-EM has been drastically…

Biomolecules · Quantitative Biology 2021-06-01 Dong Si , Andrew Nakamura , Runbang Tang , Haowen Guan , Jie Hou , Ammaar Firozi , Renzhi Cao , Kyle Hippe , Minglei Zhao

Denoising, the process of reducing random fluctuations in a signal to emphasize essential patterns, has been a fundamental problem of interest since the dawn of modern scientific inquiry. Recent denoising techniques, particularly in…

Machine Learning · Computer Science 2024-12-04 Peyman Milanfar , Mauricio Delbracio

Radar images of humans and other concealed objects are considerably distorted by attenuation, refraction and multipath clutter in indoor through-wall environments. While several methods have been proposed for removing target independent…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Shelly Vishwakarma , Shobha Sundar Ram

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution. In single particle cryo-EM, the central problem is to reconstruct the…

Quantitative Methods · Quantitative Biology 2020-02-18 Ellen D. Zhong , Tristan Bepler , Joseph H. Davis , Bonnie Berger

Microstructure imaging is crucial in materials science, but experimental images often introduce noise that obscures critical structural details. This study presents a novel deep learning approach for robust microstructure image denoising,…

Materials Science · Physics 2025-07-03 Owais Ahmad , Albert Linda , Saumya Ranjan Jha , Somnath Bhowmick

Fluoroscopy is critical for real-time X-ray visualization in medical imaging. However, low-dose images are compromised by noise, potentially affecting diagnostic accuracy. Noise reduction is crucial for maintaining image quality, especially…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Sun-Young Jeon , Sen Wang , Adam S. Wang , Garry E. Gold , Jang-Hwan Choi

Recent studies on learning-based image denoising have achieved promising performance on various noise reduction tasks. Most of these deep denoisers are trained either under the supervision of clean references, or unsupervised on synthetic…

Image and Video Processing · Electrical Eng. & Systems 2021-03-30 Rui Zhao , Daniel P. K. Lun , Kin-Man Lam

Image denoising is of great importance for medical imaging system, since it can improve image quality for disease diagnosis and downstream image analyses. In a variety of applications, dynamic imaging techniques are utilized to capture the…

Image and Video Processing · Electrical Eng. & Systems 2021-06-24 Junshen Xu , Elfar Adalsteinsson

Denoising is one of the fundamental steps of the processing pipeline that converts data captured by a camera sensor into a display-ready image or video. It is generally performed early in the pipeline, usually before demosaicking, although…

Image and Video Processing · Electrical Eng. & Systems 2024-12-02 Marco Sánchez-Beeckman , Antoni Buades , Nicola Brandonisio , Bilel Kanoun

Image restoration has been an extensively researched topic in numerous fields. With the advent of deep learning, a lot of the current algorithms were replaced by algorithms that are more flexible and robust. Deep networks have demonstrated…

Computer Vision and Pattern Recognition · Computer Science 2019-04-30 Rohit Jena

Recent works on plug-and-play image restoration have shown that a denoiser can implicitly serve as the image prior for model-based methods to solve many inverse problems. Such a property induces considerable advantages for plug-and-play…

Image and Video Processing · Electrical Eng. & Systems 2021-07-14 Kai Zhang , Yawei Li , Wangmeng Zuo , Lei Zhang , Luc Van Gool , Radu Timofte

Masked Autoencoders (MAE) have been popular paradigms for large-scale vision representation pre-training. However, MAE solely reconstructs the low-level RGB signals after the decoder and lacks supervision upon high-level semantics for the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Peng Gao , Renrui Zhang , Rongyao Fang , Ziyi Lin , Hongyang Li , Hongsheng Li , Qiao Yu

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-level visualization of biomolecular assemblies. However, the exponential growth in cryo-EM data throughput and complexity, coupled with diverse…

Quantitative Methods · Quantitative Biology 2026-02-25 Weining Fu , Kai Shu , Kui Xu , Qiangfeng Cliff Zhang

Image reconstruction in the presence of severe degradation remains a challenging inverse problem, particularly in beam diagnostics for high-energy physics accelerators. As modern facilities demand precise detection of beam halo structures…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Francis Osswald , Mohammed Chahbaoui , Xinyi Liang

Cryo-EM is an increasingly popular method for determining the atomic resolution 3D structure of macromolecular complexes (eg, proteins) from noisy 2D images captured by an electron microscope. The computational task is to reconstruct the 3D…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Shayan Shekarforoush , David B. Lindell , Marcus A. Brubaker , David J. Fleet

Recovering a high-quality image from noisy indirect measurements is an important problem with many applications. For such inverse problems, supervised deep convolutional neural network (CNN)-based denoising methods have shown strong…

Image and Video Processing · Electrical Eng. & Systems 2020-09-16 Allard A. Hendriksen , Daniel M. Pelt , K. Joost Batenburg

Deep learning approaches in image processing predominantly resort to supervised learning. A majority of methods for image denoising are no exception to this rule and hence demand pairs of noisy and corresponding clean images. Only recently…

Image and Video Processing · Electrical Eng. & Systems 2020-10-02 Priyatham Kattakinda , A. N. Rajagopalan

One of the fundamental challenges in image restoration is denoising, where the objective is to estimate the clean image from its noisy measurements. To tackle such an ill-posed inverse problem, the existing denoising approaches generally…

Computer Vision and Pattern Recognition · Computer Science 2021-11-12 Lanqing Guo , Siyu Huang , Haosen Liu , Bihan Wen

Single-particle cryo-EM has transformed structural biology but still faces challenges in resolving conformational heterogeneity at atomic resolution. Existing cryo-EM heterogeneity analysis methods either lack atomic details or tend to…

Biomolecules · Quantitative Biology 2025-10-21 Chengwei Zhang , Shimian Li , Yihao Niu , Zhen Zhu , Sihao Yuan , Sirui Liu , Yi Qin Gao

Image denoising is a fundamental task in computer vision. While prevailing deep learning-based supervised and self-supervised methods have excelled in eliminating in-distribution noise, their susceptibility to out-of-distribution (OOD)…

Computer Vision and Pattern Recognition · Computer Science 2024-03-25 Jun Cheng , Dong Liang , Shan Tan