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Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because…

Machine Learning · Computer Science 2025-12-11 Amin Tavakoli , Raswanth Murugan , Ozan Gokdemir , Arvind Ramanathan , Frances Arnold , Anima Anandkumar

Recent advancements in Large Language Models (LLMs) have emphasized the critical role of fine-tuning (FT) techniques in adapting LLMs to specific tasks, especially when retraining from scratch is computationally infeasible. Fine-tuning…

Artificial Intelligence · Computer Science 2025-10-23 Xiao Han , Zimo Zhao , Wanyu Wang , Maolin Wang , Zitao Liu , Yi Chang , Xiangyu Zhao

Large Language Models (LLMs) have showcased remarkable impacts across a wide spectrum of natural language processing tasks. Fine-tuning these pretrained models on downstream datasets provides further significant performance gains; however,…

Computation and Language · Computer Science 2026-03-19 Zhikai Li , Xiaoxuan Liu , Banghua Zhu , Zhen Dong , Qingyi Gu , Kurt Keutzer

Large Language Models (LLMs) offer promising capabilities for tackling complex reasoning tasks, including optimization problems. However, existing methods either rely on prompt engineering, which leads to poor generalization across problem…

Machine Learning · Computer Science 2025-10-23 Dong Li , Xujiang Zhao , Linlin Yu , Yanchi Liu , Wei Cheng , Zhengzhang Chen , Zhong Chen , Feng Chen , Chen Zhao , Haifeng Chen

This study examines whether Low-Rank Adaptation (LoRA) fine-tuned Large Language Models (LLMs) can approximate the performance of fully fine-tuned models in generating human-interpretable decisions and explanations for malware…

Cryptography and Security · Computer Science 2025-11-26 Stephen C. Gravereaux , Sheikh Rabiul Islam

Large language models(LLMs) have garnered significant attention and demonstrated impressive capabilities in a wide range of applications. However, due to their enormous computational costs, the deployment and application of LLMs are often…

Machine Learning · Computer Science 2025-05-30 Jialong Guo , Xinghao Chen , Yehui Tang , Yunhe Wang

The advance of Artificial Intelligence (AI) is continuously reshaping the future 6G wireless communications. Particularly, the development of Large Language Models (LLMs) offers a promising approach to effectively improve the performance…

Information Theory · Computer Science 2025-03-10 Tianyue Zheng , Linglong Dai

In education, the capability of generating human-like text of Large Language Models (LLMs) inspired work on how they can increase the efficiency of learning and teaching. We study the affordability of these models for educators and students…

Computation and Language · Computer Science 2025-03-06 Bianca Raimondi , Saverio Giallorenzo , Maurizio Gabbrielli

Large Language Models (LLMs) have emerged as a significant advancement in the field of Natural Language Processing (NLP), demonstrating remarkable capabilities in language generation and other language-centric tasks. Despite their…

Computation and Language · Computer Science 2024-02-27 Tasnim Ahmed , Nicola Piovesan , Antonio De Domenico , Salimur Choudhury

Recently, the number of off-the-shelf Large Language Models (LLMs) has exploded with many open-source options. This creates a diverse landscape regarding both serving options (e.g., inference on local hardware vs remote LLM APIs) and model…

Machine Learning · Computer Science 2024-12-18 Dimitrios Sikeridis , Dennis Ramdass , Pranay Pareek

Parameter Efficient Fine-Tuning (PEFT) methods are proposed as an alternative fine-tuning approach for Large Language Models (LLM) to minimize high training costs. While prior research demonstrates the effectiveness of PEFT methods in…

Software Engineering · Computer Science 2025-01-28 Amirreza Esmaeili , Iman Saberi , Fatemeh H. Fard

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

Large language models (LLMs) excel in language tasks, especially with supervised fine-tuning after pre-training. However, their substantial memory and computational requirements hinder practical applications. Structural pruning, which…

Machine Learning · Computer Science 2025-01-28 Yijiang Liu , Huanrui Yang , Youxin Chen , Rongyu Zhang , Miao Wang , Yuan Du , Li Du

Personalization of Large Language Models (LLMs) is important in practical applications to accommodate the individual needs of different mobile users. Due to data privacy concerns, LLM personalization often needs to be locally done at the…

Machine Learning · Computer Science 2025-06-10 Haoming Wang , Boyuan Yang , Xiangyu Yin , Wei Gao

Large Language Models (LLMs) have shown remarkable success in supporting a wide range of knowledge-intensive tasks. In specialized domains, there is growing interest in leveraging LLMs to assist subject matter experts with domain-specific…

Computation and Language · Computer Science 2025-12-01 Aman Kumar , Ekant Muljibhai Amin , Xian Yeow Lee , Lasitha Vidyaratne , Ahmed K. Farahat , Dipanjan D. Ghosh , Yuta Koreeda , Chetan Gupta

Fine-tuning and inference with large Language Models (LM) are generally known to be expensive. Parameter-efficient fine-tuning over pretrained LMs reduces training memory by updating a small number of LM parameters but does not improve…

Computation and Language · Computer Science 2024-06-05 Bowen Zhao , Hannaneh Hajishirzi , Qingqing Cao

Large language models (LLMs) have shown great potential in domain-specific machine translation (MT). However, one major issue is that LLMs pre-trained on general domain corpus might not generalize well to specific domains due to the lack of…

Computation and Language · Computer Science 2024-12-18 Jiawei Zheng , Hanghai Hong , Feiyan Liu , Xiaoli Wang , Jingsong Su , Yonggui Liang , Shikai Wu

The introduction of large language models (LLMs) has enhanced automation in software engineering tasks, including in Model Driven Engineering (MDE). However, using general-purpose LLMs for domain modeling has its limitations. One approach…

Software Engineering · Computer Science 2025-07-22 Vladyslav Bulhakov , Giordano d'Aloisio , Claudio Di Sipio , Antinisca Di Marco , Davide Di Ruscio

A new paradigm for machine translation has recently emerged: fine-tuning large language models (LLM) on parallel text has been shown to outperform dedicated translation systems trained in a supervised fashion on much larger amounts of…

Computation and Language · Computer Science 2024-06-03 Aquia Richburg , Marine Carpuat

Conventional mechanical design follows an iterative process in which initial concepts are refined through cycles of expert assessment and resource-intensive Finite Element Method (FEM) analysis to meet performance goals. While machine…

Machine Learning · Computer Science 2025-05-02 Yayati Jadhav , Amir Barati Farimani
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