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200 papers

Matching patients to clinical trials is a key unsolved challenge in bringing new drugs to market. Today, identifying patients who meet a trial's eligibility criteria is highly manual, taking up to 1 hour per patient. Automated screening is…

Computation and Language · Computer Science 2024-04-11 Michael Wornow , Alejandro Lozano , Dev Dash , Jenelle Jindal , Kenneth W. Mahaffey , Nigam H. Shah

Large Language Models (LLMs) recently achieved great success in medical text summarization by simply using in-context learning. However, these recent efforts do not perform fine-grained evaluations under difficult settings where LLMs might…

Computation and Language · Computer Science 2026-04-22 Gunjan Balde , Soumyadeep Roy , Mainack Mondal , Niloy Ganguly

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Large Language Models (LLMs) are constrained by their inability to process lengthy inputs, resulting in the loss of critical historical information. To address this limitation, in this paper, we propose the Self-Controlled Memory (SCM)…

Computation and Language · Computer Science 2025-03-19 Bing Wang , Xinnian Liang , Jian Yang , Hui Huang , Shuangzhi Wu , Peihao Wu , Lu Lu , Zejun Ma , Zhoujun Li

Corpus distillation for biomedical large language models (LLMs) seeks to address the pressing challenge of insufficient quantity and quality in open-source annotated scientific corpora, which remains a bottleneck for effective LLM training…

Computation and Language · Computer Science 2025-12-19 Meng Xiao , Xunxin Cai , Qingqing Long , Chengrui Wang , Yuanchun Zhou , Hengshu Zhu

Large language models (LLMs) show promise in drafting responses to patient portal messages, yet their integration into clinical workflows raises various concerns, including whether they would actually save clinicians time and effort in…

Computation and Language · Computer Science 2026-01-19 Parker Seegmiller , Joseph Gatto , Sarah E. Greer , Ganza Belise Isingizwe , Rohan Ray , Timothy E. Burdick , Sarah Masud Preum

The medical ecosystem consists of the training of new clinicians and researchers, the practice of clinical medicine, and areas of adjacent research. There are many aspects of these domains that could benefit from the application of task…

Computers and Society · Computer Science 2025-07-29 Elisha D. O. Roberson

Large Language Models (LLMs) can provide accurate word definitions and explanations for any context. However, the scope of the definition changes for different target groups, like children or language learners. This is especially relevant…

Computation and Language · Computer Science 2025-07-17 Lukas Ellinger , Miriam Anschütz , Georg Groh

Text Simplification improves the readability of sentences through several rewriting transformations, such as lexical paraphrasing, deletion, and splitting. Current simplification systems are predominantly sequence-to-sequence models that…

Computation and Language · Computer Science 2021-04-16 Mounica Maddela , Fernando Alva-Manchego , Wei Xu

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Medical multi-document summarization (MDS) is a complex task that requires effectively managing cross-document relationships. This paper investigates whether incorporating hierarchical structures in the inputs of MDS can improve a model's…

Computation and Language · Computer Science 2025-11-05 Yi-Li Hsu , Katelyn X. Mei , Lucy Lu Wang

Large Language Models (LLMs) have rapidly evolved from text-based systems to multimodal platforms, significantly impacting various sectors including healthcare. This comprehensive review explores the progression of LLMs to Multimodal Large…

LLMs are popular among clinicians for decision-support because of simple text-based interaction. However, their impact on clinicians' performance is ambiguous. Not knowing how clinicians use this new technology and how they compare it to…

Human-Computer Interaction · Computer Science 2026-02-02 Behnam Rahdari , Sameer Shaikh , Jonathan H Chen , Tobias Gerstenberg , Shriti Raj

This paper challenges the prevailing tendency to frame Large Language Models (LLMs) as cognitive systems, arguing instead for a semiotic perspective that situates these models within the broader dynamics of sign manipulation and…

Computation and Language · Computer Science 2026-03-30 Davide Picca

This study evaluates the linguistic and clinical suitability of synthetic electronic health records in mental health. First, we describe the rationale and the methodology for creating the synthetic corpus. Second, we examine expressions of…

Computation and Language · Computer Science 2026-02-05 Serge Sharoff , John Baker , David Francis Hunt , Alan Simpson

Automatic medical text simplification plays a key role in improving health literacy by making complex biomedical research accessible to diverse readers. However, most existing resources assume a single generic audience, overlooking the wide…

Computation and Language · Computer Science 2025-12-04 Rohan Charudatt Salvi , Chirag Chawla , Dhruv Jain , Swapnil Panigrahi , Md Shad Akhtar , Shweta Yadav

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Large language models (LLMs) have shown great potential in the medical domain. However, existing models still fall short when faced with complex medical diagnosis task in the real world. This is mainly because they lack sufficient reasoning…

Artificial Intelligence · Computer Science 2025-08-06 Qi Peng , Jialin Cui , Jiayuan Xie , Yi Cai , Qing Li

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Autonomous agents empowered by Large Language Models (LLMs) have undergone significant improvements, enabling them to generalize across a broad spectrum of tasks. However, in real-world scenarios, cooperation among individuals is often…