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We present a novel method for variable selection in regression models when covariates are measured with error. The iterative algorithm we propose, MEBoost, follows a path defined by estimating equations that correct for covariate…

Computation · Statistics 2017-10-26 Benjamin Brown , Timothy Weaver , Julian Wolfson

In observational studies with survival or time-to-event outcomes, a propensity score weighted marginal Cox proportional hazard model with the treatment variable as the only predictor is commonly used to estimate the causal marginal hazard…

Methodology · Statistics 2026-02-02 Zixian Zhao , Chengxin Yang , Fan Li

We consider survival data from a population with cured subjects in the presence of mismeasured covariates. We use the mixture cure model to account for the individuals that will never experience the event and at the same time distinguish…

Methodology · Statistics 2020-09-15 Eni Musta , Ingrid Van Keilegom

Fully Bayesian methods for Cox models specify a model for the baseline hazard function. Parametric approaches generally provide monotone estimations. Semi-parametric choices allow for more flexible patterns but they can suffer from…

Methodology · Statistics 2024-02-01 Elena Lázaro , Carmen Armero , Danilo Alvares

Across diverse biological systems -- ranging from neural networks to intracellular signaling and genetic regulatory networks -- the information about changes in the environment is frequently encoded in the full temporal dynamics of the…

Quantitative Methods · Quantitative Biology 2020-07-01 Sarah A Cepeda-Humerez , Jakob Ruess , Gašper Tkačik

In this paper, we expand the methodology presented in Mertens et. al (2020, Biometrical Journal) to the study of life-time (survival) outcome which is subject to censoring and when imputation is used to account for missing values. We…

Methodology · Statistics 2021-05-06 Bart J. A. Mertens

High-dimensional compositional covariates, often derived from count data, are subject to measurement error and are frequently analyzed after aggregation along a prespecified tree to improve interpretability in applications such as…

Methodology · Statistics 2026-05-18 Zhenghan Li , Tianying Wang

Post-earthquake hazard and impact estimation are critical for effective disaster response, yet current approaches face significant limitations. Traditional models employ fixed parameters regardless of geographical context, misrepresenting…

Machine Learning · Statistics 2025-04-08 Xuechun Li , Shan Gao , Runyu Gao , Susu Xu

Estimating treatment effects in networks is challenging, as each potential outcome depends on the treatments of all other nodes in the network. To overcome this difficulty, existing methods typically impose an exposure mapping that…

Machine Learning · Computer Science 2026-02-04 Maresa Schröder , Miruna Oprescu , Stefan Feuerriegel , Nathan Kallus

While extensive work has been done to correct for biases due to measurement error in scalar-valued covariates prone to errors in generalized linear regression models, limited work has been done to address biases associated with functional…

Methodology · Statistics 2023-05-16 Yuanyuan Luan , Roger S. Zoh , Sneha Jadhav , Lan Xue , Carmen D. Tekwe

Survival analysis is a widely-used technique for analyzing time-to-event data in the presence of censoring. In recent years, numerous survival analysis methods have emerged which scale to large datasets and relax traditional assumptions…

Machine Learning · Computer Science 2023-11-06 Mert Ketenci , Shreyas Bhave , Noémie Elhadad , Adler Perotte

Motivated by multi-center biomedical studies that cannot share individual data due to privacy and ownership concerns, we develop communication-efficient iterative distributed algorithms for estimation and inference in the high-dimensional…

Methodology · Statistics 2024-06-25 Pierre Bayle , Jianqing Fan , Zhipeng Lou

The motivation of this article is to improve inferences on the covariation in environmental exposures, motivated by data from a study of Toddlers Exposure to SVOCs in Indoor Environments (TESIE). The challenge is that the sample size is…

Methodology · Statistics 2026-05-20 Elizabeth Bersson , Kate Hoffman , Heather M. Stapleton , David B. Dunson

We consider the problem in precision health of grouping people into subpopulations based on their degree of vulnerability to a risk factor. These subpopulations cannot be discovered with traditional clustering techniques because their…

Machine Learning · Statistics 2018-12-11 Alexander New , Kristin P. Bennett

The purpose of this work is to improve the efficiency in estimating the average causal effect (ACE) on the survival scale where right-censoring exists and high-dimensional covariate information is available. We propose new estimators using…

Methodology · Statistics 2021-06-29 Ran Dai , Cheng Zheng , Mei-Jie Zhang

We present an approach to estimate distance-dependent heterogeneous associations between point-referenced exposures to built environment characteristics and health outcomes. By estimating associations that depend non-linearly on distance…

Methodology · Statistics 2021-07-14 Adam Peterson , Emma Sanchez-Vaznaugh , Brisa Sanchez

Exposure assessment is fundamental to air pollution cohort studies. The objective is to predict air pollution exposures for study subjects at locations without data in order to optimize our ability to learn about health effects of air…

Applications · Statistics 2024-06-05 Si Cheng , Magali N. Blanco , Lianne Sheppard , Ali Shojaie , Adam Szpiro

Environmental data may be "large" due to number of records, number of covariates, or both. Random forests has a reputation for good predictive performance when using many covariates with nonlinear relationships, whereas spatial regression,…

Applications · Statistics 2018-12-27 Eric W. Fox , Jay M. Ver Hoef , Anthony R. Olsen

Relative survival represents the preferred framework for the analysis of population cancer survival data. The aim is to model the survival probability associated to cancer in the absence of information about the cause of death. Recent data…

Survival analysis, or time-to-event analysis, is an important and widespread problem in healthcare research. Medical research has traditionally relied on Cox models for survival analysis, due to their simplicity and interpretability. Cox…

Machine Learning · Computer Science 2023-10-25 Mike Van Ness , Tomas Bosschieter , Natasha Din , Andrew Ambrosy , Alexander Sandhu , Madeleine Udell