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New computational strategies, such as molecular docking, are emerging to speed up the drug discovery process. This method predicts the activity of molecules at the binding site of proteins, helping to select the ones that exhibit desirable…

Quantum Physics · Physics 2024-02-13 Mathieu Garrigues , Victor Onofre , Noé Bosc-Haddad

Many artificial intelligence (AI) problems naturally map to NP-hard optimization problems. This has the interesting consequence that enabling human-level capability in machines often requires systems that can handle formally intractable…

Quantum Physics · Physics 2009-09-29 Hartmut Neven , Geordie Rose , William G. Macready

We analyze the complexity of the quantum optimization algorithm based on adiabatic evolution for the set partition problem. We introduce a cost function defined on a logarithmic scale of the partition residues so that the total number of…

Quantum Physics · Physics 2007-05-23 V. N. Smelyanskiy , U. V. Toussaint , D. A. Timucin

The D-Wave adiabatic quantum annealer solves hard combinatorial optimization problems leveraging quantum physics. The newest version features over 1000 qubits and was released in August 2015. We were given access to such a machine,…

Databases · Computer Science 2015-10-23 Immanuel Trummer , Christoph Koch

In this review we consider the performance of the quantum adiabatic algorithm for the solution of decision problems. We divide the possible failure mechanisms into two sets: small gaps due to quantum phase transitions and small gaps due to…

Quantum Physics · Physics 2015-04-21 C. R. Laumann , R. Moessner , A. Scardicchio , S. L. Sondhi

Solving linear systems of equations is a fundamental problem with a wide variety of applications across many fields of science, and there is increasing effort to develop quantum linear solver algorithms. [Suba\c{s}i et al., Phys. Rev. Lett.…

Quantum Physics · Physics 2026-01-09 David Jennings , Matteo Lostaglio , Sam Pallister , Andrew T Sornborger , Yiğit Subaşı

We consider a classical and superadiabatic version of an iterative quantum adiabatic algorithm to solve combinatorial optimization problems. This algorithm is deterministic because it is based on purely classical dynamics, that is, it does…

Statistical Mechanics · Physics 2020-05-08 Takuya Hatomura

An adiabatic quantum algorithm is essentially given by three elements: An initial Hamiltonian with known ground state, a problem Hamiltonian whose ground state corresponds to the solution of the given problem and an evolution schedule such…

Quantum Physics · Physics 2019-09-17 Davide Pastorello , Enrico Blanzieri

Quantum-classical hybrid algorithms offer a promising strategy for tackling computationally challenging problems, such as the maximum independent set (MIS) problem that plays a crucial role in areas like network design and data analysis.…

Quantum Physics · Physics 2025-06-17 Seokho Jeong , Juyoung Park , Jaewook Ahn

We present an analog version of the quantum approximate optimization algorithm suitable for current quantum annealers. The central idea of this algorithm is to optimize the schedule function, which defines the adiabatic evolution. It is…

The ability to efficiently prepare ground states of quantum Hamiltonians via adiabatic protocols is typically limited by the smallest energy gap encountered during the quantum evolution. This presents a key obstacle for quantum simulation…

In the circuit model of quantum computing, amplitude amplification techniques can be used to find solutions to NP-hard problems defined on $n$-bits in time $\text{poly}(n) 2^{n/2}$. In this work, we investigate whether such general…

Quantum Annealing (QA) can be used to quickly obtain near-optimal solutions for Quadratic Unconstrained Binary Optimization (QUBO) problems. In QA hardware, each decision variable of a QUBO should be mapped to one or more adjacent qubits in…

Data Structures and Algorithms · Computer Science 2021-01-21 Thiago Serra , Teng Huang , Arvind Raghunathan , David Bergman

A quadratic speedup of the quantum adiabatic algorithm (QAA) for finding independent sets (ISs) in a graph is proven analytically. In comparison to the best classical algorithm with $O(n^2)$ scaling, where $n$ is the number of vertexes, our…

Quantum Physics · Physics 2025-10-31 Xianjue Zhao , Peiyun Ge , Li You , Biao Wu

Quantum computation has emerged as a powerful computational medium of our time, having demonstrated the remarkable efficiency in factoring a positive integer and searching databases faster than any currently known classical computing…

Quantum Physics · Physics 2024-04-16 Tomoyuki Yamakami

This paper explores several aspects of the adiabatic quantum computation model. We first show a way that directly maps any arbitrary circuit in the standard quantum computing model to an adiabatic algorithm of the same depth. Specifically,…

Quantum Physics · Physics 2009-11-10 M. Stewart Siu

A scalable superconducting architecture for adiabatic quantum computers is proposed. The architecture is based on time-independent, nearest-neighbor interqubit couplings: it can handle any problem in the class NP even in the presence of…

Quantum Physics · Physics 2007-05-23 William M. Kaminsky , Seth Lloyd , Terry P. Orlando

We study the glued-trees problem of Childs et. al. in the adiabatic model of quantum computing and provide an annealing schedule to solve an oracular problem exponentially faster than classically possible. The Hamiltonians involved in the…

Quantum Physics · Physics 2013-05-30 Daniel Nagaj , Rolando D. Somma , Maria Kieferova

To date, research in quantum computation promises potential for outperforming classical heuristics in combinatorial optimization. However, when aiming at provable optimality, one has to rely on classical exact methods like integer…

Quantum Physics · Physics 2025-03-13 Friedrich Wagner , Jonas Nüßlein , Frauke Liers

We develop a non-cooperative game-theoretic model for the problem of graph minor-embedding to show that optimal compiling of adiabatic quantum programs in the sense of Nash equilibrium is possible.

Computer Science and Game Theory · Computer Science 2019-03-20 Faisal Shah Khan , Nada Elsokkary , Travis S. Humble