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Advances in single-cell omics allow for unprecedented insights into the transcription profiles of individual cells. When combined with large-scale perturbation screens, through which specific biological mechanisms can be targeted, these…

Machine Learning · Computer Science 2023-10-24 Alejandro Tejada-Lapuerta , Paul Bertin , Stefan Bauer , Hananeh Aliee , Yoshua Bengio , Fabian J. Theis

Causal Impact (CI) of customer actions are broadly used across the industry to inform both short- and long-term investment decisions of various types. In this paper, we apply the double machine learning (DML) methodology to estimate the CI…

Machine Learning · Computer Science 2024-09-05 Sushant More , Priya Kotwal , Sujith Chappidi , Dinesh Mandalapu , Chris Khawand

Machine learning models have had discernible achievements in a myriad of applications. However, most of these models are black-boxes, and it is obscure how the decisions are made by them. This makes the models unreliable and untrustworthy.…

Machine Learning · Computer Science 2020-03-23 Raha Moraffah , Mansooreh Karami , Ruocheng Guo , Adrienne Raglin , Huan Liu

Automated decision making is used routinely throughout our everyday life. Recommender systems decide which jobs, movies, or other user profiles might be interesting to us. Spell checkers help us to make good use of language. Fraud detection…

Machine Learning · Computer Science 2020-07-15 Alexander Jung , Pedro H. J. Nardelli

Deferring systems extend supervised Machine Learning (ML) models with the possibility to defer predictions to human experts. However, evaluating the impact of a deferring strategy on system accuracy is still an overlooked area. This paper…

Machine Learning · Computer Science 2025-04-08 Filippo Palomba , Andrea Pugnana , José Manuel Alvarez , Salvatore Ruggieri

The use of machine learning (ML) in high-stakes societal decisions has encouraged the consideration of fairness throughout the ML lifecycle. Although data integration is one of the primary steps to generate high quality training data, most…

Machine Learning · Computer Science 2022-04-01 Sainyam Galhotra , Karthikeyan Shanmugam , Prasanna Sattigeri , Kush R. Varshney

To make effective decisions, it is important to have a thorough understanding of the causal relationships among actions, environments, and outcomes. This review aims to surface three crucial aspects of decision-making through a causal lens:…

Machine Learning · Statistics 2026-04-22 Lin Ge , Hengrui Cai , Runzhe Wan , Yang Xu , Rui Song

The rapid increase in computing power and the ability to store Big Data in the infrastructure has enabled predictions in a large variety of domains by Machine Learning. However, in many cases, existing Machine Learning tools are considered…

Machine Learning · Computer Science 2025-07-02 Nikolaos-Lysias Kosioris , Sotirios Nikoletseas , Gavrilis Filios , Stefanos Panagiotou

The convenient access to copious multi-faceted data has encouraged machine learning researchers to reconsider correlation-based learning and embrace the opportunity of causality-based learning, i.e., causal machine learning (causal…

Machine Learning · Computer Science 2022-02-08 Lu Cheng , Ruocheng Guo , Raha Moraffah , Paras Sheth , K. Selcuk Candan , Huan Liu

Uncovering causal relationships in data is a major objective of data analytics. Causal relationships are normally discovered with designed experiments, e.g. randomised controlled trials, which, however are expensive or infeasible to be…

Artificial Intelligence · Computer Science 2016-11-01 Jiuyong Li , Saisai Ma , Thuc Duy Le , Lin Liu , Jixue Liu

Uncertainty quantification of causal effects is crucial for safety-critical applications such as personalized medicine. A powerful approach for this is conformal prediction, which has several practical benefits due to model-agnostic…

Machine Learning · Computer Science 2026-02-04 Maresa Schröder , Dennis Frauen , Jonas Schweisthal , Konstantin Heß , Valentyn Melnychuk , Stefan Feuerriegel

The advances in Artificial Intelligence (AI) and Machine Learning (ML) have opened up many avenues for scientific research, and are adding new dimensions to the process of knowledge creation. However, even the most powerful and versatile of…

Artificial Intelligence · Computer Science 2023-11-10 Jorawar Singh , Kishor Bharti , Arvind

The emergence and continued reliance on the Internet and related technologies has resulted in the generation of large amounts of data that can be made available for analyses. However, humans do not possess the cognitive capabilities to…

Machine Learning · Computer Science 2021-01-12 MohammadNoor Injadat , Abdallah Moubayed , Ali Bou Nassif , Abdallah Shami

The science of causality explains/determines 'cause-effect' relationship between the entities of a system by providing mathematical tools for the purpose. In spite of all the success and widespread applications of machine-learning (ML)…

Machine Learning · Computer Science 2021-12-07 Aditi Kathpalia , Keerti P. Charantimath , Nithin Nagaraj

In application domains such as healthcare, we want accurate predictive models that are also causally interpretable. In pursuit of such models, we propose a causal regularizer to steer predictive models towards causally-interpretable…

Machine Learning · Computer Science 2017-02-24 Mohammad Taha Bahadori , Krzysztof Chalupka , Edward Choi , Robert Chen , Walter F. Stewart , Jimeng Sun

Causal machine learning (ML) recovers graphical structures that inform us about potential cause-and-effect relationships. Most progress has focused on cross-sectional data with no explicit time order, whereas recovering causal structures…

Machine Learning · Computer Science 2026-05-11 Bruno Petrungaro , Anthony C. Constantinou

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

Clinical predictive algorithms are increasingly being used to form the basis for optimal treatment policies--that is, to enable interventions to be targeted to the patients who will presumably benefit most. Despite taking advantage of…

Applications · Statistics 2020-07-21 Ben J. Marafino , Alejandro Schuler , Vincent X. Liu , Gabriel J. Escobar , Mike Baiocchi

It is crucial to consider the social and ethical consequences of AI and ML based decisions for the safe and acceptable use of these emerging technologies. Fairness, in particular, guarantees that the ML decisions do not result in…

Artificial Intelligence · Computer Science 2022-06-15 Rūta Binkytė-Sadauskienė , Karima Makhlouf , Carlos Pinzón , Sami Zhioua , Catuscia Palamidessi
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