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Inferring the causal structure of a system typically requires interventional data, rather than just observational data. Since interventional experiments can be costly, it is preferable to select interventions that yield the maximum amount…

Methodology · Statistics 2021-03-30 Michele Zemplenyi , Jeffrey W. Miller

Time-series experiments, also called switchback experiments or N-of-1 trials, play increasingly important roles in modern applications in medical and industrial areas. Under the potential outcomes framework, recent research has studied…

Methodology · Statistics 2025-10-28 Zhexiao Lin , Peng Ding

In this article, universally optimal multivariate crossover designs are studied. The multiple response crossover design is motivated by a $3 \times 3$ crossover setup, where the effect of $3$ doses of an oral drug are studied on gene…

Methodology · Statistics 2024-07-16 Shubham Niphadkar , Siuli Mukhopadhyay

We consider the problem of inference in shift-share research designs. The choice between existing approaches that allow for unrestricted spatial correlation involves tradeoffs, varying in terms of their validity when there are relatively…

Econometrics · Economics 2022-06-03 Luis Alvarez , Bruno Ferman , Raoni Oliveira

We provide a review of the experimental and theoretical research in the field of quantum tomography with an emphasis on recently developed adaptive protocols. Several statistical frameworks for adaptive experimental design are discussed. We…

Quantum Physics · Physics 2016-11-03 Stanislav Straupe

Transfer learning is a burgeoning concept in statistical machine learning that seeks to improve inference and/or predictive accuracy on a domain of interest by leveraging data from related domains. While the term "transfer learning" has…

Machine Learning · Statistics 2023-12-22 Piotr M. Suder , Jason Xu , David B. Dunson

The determination of the sample size required by a crossover trial typically depends on the specification of one or more variance components. Uncertainty about the value of these parameters at the design stage means that there is often a…

Methodology · Statistics 2018-03-28 Michael Grayling , Adrian Mander , James Wason

Large amount of multidimensional data represented by multiway arrays or tensors are prevalent in modern applications across various fields such as chemometrics, genomics, physics, psychology, and signal processing. The structural complexity…

Statistics Theory · Mathematics 2024-05-29 Arnab Auddy , Dong Xia , Ming Yuan

Deep learning fostered a leap ahead in automated skin lesion analysis in the last two years. Those models are expensive to train and difficult to parameterize. Objective: We investigate methodological issues for designing and evaluating…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Eduardo Valle , Michel Fornaciali , Afonso Menegola , Julia Tavares , Flávia Vasques Bittencourt , Lin Tzy Li , Sandra Avila

This article is due to appear in the Handbook of Statistics, Vol. 43, Elsevier/North-Holland, Amsterdam, edited by Arni S. R. Srinivasa Rao and C. R. Rao. In modern day analytics, there is ever growing need to develop statistical models to…

Statistics Theory · Mathematics 2019-08-20 Deepak Nag Ayyala

A crossover trial is an efficient trial design when there is no carry-over effect. To reduce the impact of the biological carry-over effect, a washout period is often designed. However, the carry-over effect remains an outstanding concern…

Applications · Statistics 2024-03-06 Danni Shi , Ting Ye

Cross-validation is one of the most popular model selection methods in statistics and machine learning. Despite its wide applicability, traditional cross validation methods tend to select overfitting models, due to the ignorance of the…

Methodology · Statistics 2017-12-25 Jing Lei

Crossover designs are an extremely useful tool to investigators, whilst group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover designs have…

Methodology · Statistics 2017-10-11 Michael Grayling , James Wason , Adrian Mander

The problem of statistical inference in its various forms has been the subject of decades-long extensive research. Most of the effort has been focused on characterizing the behavior as a function of the number of available samples, with far…

Machine Learning · Computer Science 2024-11-12 Tomer Berg , Or Ordentlich , Ofer Shayevitz

Over time, clinical trials have increasingly incorporated complex design and analysis elements such as interim analyses, adaptations, multiple endpoints, and sophisticated multiplicity schemes for multiple endpoints and/or treatment arms…

We provide a review of recent developments in the calculation of standard errors and test statistics for statistical inference. While much of the focus of the last two decades in economics has been on generating unbiased coefficients,…

Econometrics · Economics 2024-10-04 Jeffrey D. Michler , Anna Josephson

The study of experimental design offers tremendous benefits for answering causal questions across a wide range of applications, including agricultural experiments, clinical trials, industrial experiments, social experiments, and digital…

Methodology · Statistics 2024-08-27 Jinglong Zhao

AB testing aids business operators with their decision making, and is considered the gold standard method for learning from data to improve digital user experiences. However, there is usually a gap between the requirements of practitioners,…

Machine Learning · Computer Science 2023-07-28 Srivas Chennu , Andrew Maher , Christian Pangerl , Subash Prabanantham , Jae Hyeon Bae , Jamie Martin , Bud Goswami

Data with spatial-temporal attributes are prevalent across many research fields, and statistical models for analyzing spatio-temporal relationships are widely used. Existing reviews focus either on specific domains or model types, creating…

Applications · Statistics 2025-11-04 Isabella Habereder , Thomas Kneib , Isao Echizen , Timo Spinde

Hyperbolic cross approximation is a special type of multivariate approximation. Recently, driven by applications in engineering, biology, medicine and other areas of science new challenging problems have appeared. The common feature of…

Numerical Analysis · Mathematics 2017-04-24 Dinh Dũng , Vladimir N. Temlyakov , Tino Ullrich