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The long-term effects of Postacute Sequelae of SARS-CoV-2, known as PASC, pose a significant challenge to healthcare systems worldwide. Accurate identification of progression events, such as hospitalization and reinfection, is essential for…

Machine Learning · Computer Science 2025-07-01 Jing Wang , Amar Sra , Jeremy C. Weiss

Post-acute sequelae of SARS-CoV-2 infection (Long COVID) frequently persists for months, yet drivers of clinical remission remain incompletely defined. Here we analyzed 97,564 longitudinal PASC assessments from 13,511 participants with…

Other Quantitative Biology · Quantitative Biology 2026-01-14 Jing Wang , Tong Zhang , Xing Niu , Jie Shen , Yiming Luo , Qiaomin Xie , Amar Sra , Zorina Galis , Jeremy Weiss

Post-acute sequelae of SARS-CoV-2 (PASC) is an increasingly recognized yet incompletely understood public health concern. Several studies have examined various ways to phenotype PASC to better characterize this heterogeneous condition.…

Quantitative Methods · Quantitative Biology 2023-08-09 Sarah Pungitore , Toluwanimi Olorunnisola , Jarrod Mosier , Vignesh Subbian

It is shown that various symptoms could remain in the stage of post-acute sequelae of SARS-CoV-2 infection (PASC), otherwise known as Long COVID. A number of COVID patients suffer from heterogeneous symptoms, which severely impact recovery…

Quantitative Methods · Quantitative Biology 2022-11-17 Sihang Jiang , Johanna Loomba , Suchetha Sharma , Donald Brown

Post-acute sequelae of SARS-CoV-2 infection (PASC) or Long COVID is an emerging medical condition that has been observed in several patients with a positive diagnosis for COVID-19. Historical Electronic Health Records (EHR) like diagnosis…

Early prediction of Post-Acute Sequelae of SARS-CoV-2 severity is a critical challenge for women's health, particularly given the diagnostic overlap between PASC and common hormonal transitions such as menopause. Identifying and accounting…

Machine Learning · Computer Science 2026-03-19 Jing Wang , Jie Shen , Yiming Luo , Amar Sra , Qiaomin Xie , Jeremy C. Weiss

Accurately and efficiently diagnosing Post-Acute Sequelae of COVID-19 (PASC) remains challenging due to its myriad symptoms that evolve over long- and variable-time intervals. To address this issue, we developed a hybrid natural language…

Based on recent studies, some COVID-19 symptoms can persist for months after infection, leading to what is termed long COVID. Factors such as vaccination timing, patient characteristics, and symptoms during the acute phase of infection may…

Machine Learning · Computer Science 2025-04-30 Milad Leyli-abadi , Jean-Patrick Brunet , Axel Tahmasebimoradi

A significant percentage of COVID-19 survivors experience ongoing multisystemic symptoms that often affect daily living, a condition known as Long Covid or post-acute-sequelae of SARS-CoV-2 infection. However, identifying scientific…

Machine Learning · Computer Science 2022-10-31 Robert Leaman , Rezarta Islamaj , Alexis Allot , Qingyu Chen , W. John Wilbur , Zhiyong Lu

The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain of coronavirus that caused the COVID-19 pandemic, is broad, extending from asymptomatic infection to severe immunopulmonary reactions that, if…

Quantitative Methods · Quantitative Biology 2022-07-18 Aaron Wang , Feng Li , Samantha Chiang , Jennifer Fulcher , Otto Yang , David Wong , Fang Wei

SARS-CoV-2, the highly contagious pathogen responsible for the COVID-19 pandemic, has persistent effects that begin four weeks after initial infection and last for an undetermined duration. These chronic effects are more harmful than acute…

While the acute phase of the COVID-19 pandemic has subsided, its long-term effects persist through Post-Acute Sequelae of COVID-19 (PASC), commonly known as Long COVID. There remains substantial uncertainty regarding both its duration and…

Coronavirus Disease 2019 (COVID-19) is a rapidly emerging respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the rapid human-to-human transmission of SARS-CoV-2, many healthcare systems…

Machine Learning · Computer Science 2020-12-01 Patrick Schwab , August DuMont Schütte , Benedikt Dietz , Stefan Bauer

Monitoring the incidence of new infections during a pandemic is critical for an effective public health response. General population prevalence surveys for SARS-CoV-2 can provide high-quality data to estimate incidence. However, estimation…

For infectious diseases, characterizing symptom duration is of clinical and public health importance. Symptom duration may be assessed by surveying infected individuals and querying symptom status at the time of survey response. For…

Severe acute respiratory disease SARS-CoV-2 has had a found impact on public health systems and healthcare emergency response especially with respect to making decisions on the most effective measures to be taken at any given time. As…

Machine Learning · Computer Science 2023-09-19 Charithea Stylianides , Kleanthis Malialis , Panayiotis Kolios

Post-COVID Syndrome (PCS), encompassing the multifaceted sequelae of COVID-19, can be severity-graded using a score comprising 12 different long-term symptom complexes. Acute COVID-19 severity and individual resilience were previously…

Through the use of cutting-edge unsupervised classification techniques from statistics and machine learning, we characterise symptom phenotypes among symptomatic SARS-CoV-2 PCR-positive community cases. We first analyse each dataset in…

Due to the rapidly evolving COVID-19 pandemic caused by the SARS-CoV-2 virus, quick public health investigations of the relationships between behaviours and infection risk are essential. Recently the test-negative design was proposed to…

Methodology · Statistics 2021-02-09 Mireille E. Schnitzer , Daphna Harel , Vikki Ho , Anita Koushik , Joanna Merckx

There are many sources of data giving information about the number of SARS-CoV-2 infections in the population, but all have major drawbacks, including biases and delayed reporting. For example, the number of confirmed cases largely…

Applications · Statistics 2022-06-08 Nicholas J. Irons , Adrian E. Raftery
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