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Parkinsons disease (PD) alters cortical neural dynamics, yet reliable non-invasive electrophysiological biomarkers remain elusive. This study examined whether interpretable EEG features capturing complementary aspects of neural dynamics can…

Neurons and Cognition · Quantitative Biology 2026-04-14 Antonios G. Dougalis

Parkinsons Disease (PD) is a neurodegenerative disorder resulting in motor deficits due to advancing degeneration of dopaminergic neurons. PD patients report experiencing tremor, rigidity, visual impairment, bradykinesia, and several…

Computer Vision and Pattern Recognition · Computer Science 2023-04-05 Krish Desai

The extraction of brain functioning features is a crucial step in the definition of brain-computer interfaces (BCIs). In the last decade, functional connectivity (FC) estimators have been increasingly explored based on their ability to…

Neurons and Cognition · Quantitative Biology 2019-12-06 Tiziana Cattai , Stefania Colonnese , Marie-Constance Corsi , Danielle S. Bassett , Gaetano Scarano , Fabrizio De Vico Fallani

This study investigates EEG as a potential early biomarker by applying deep learning techniques to resting-state EEG recordings from 31 subjects (15 with PD and 16 healthy controls). EEG signals underwent preprocessing to remove tremor…

Neurons and Cognition · Quantitative Biology 2025-03-25 Artem Lensky

Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and…

Neurons and Cognition · Quantitative Biology 2018-02-07 Liviu Badea , Mihaela Onu , Tao Wu , Adina Roceanu , Ovidiu Bajenaru

While Parkinson's disease (PD) is typically characterized by motor disorder, there is evidence of diminished emotion perception in PD patients. This study examines the utility of affective Electroencephalography (EEG) signals to understand…

Signal Processing · Electrical Eng. & Systems 2022-03-01 Ravikiran Parameshwara , Soujanya Narayana , Murugappan Murugappan , Ramanathan Subramanian , Ibrahim Radwan , Roland Goecke

Human brain functional connectivity (FC) is often measured as the similarity of functional MRI responses across brain regions when a brain is either resting or performing a task. This paper aims to statistically analyze the dynamic nature…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Mengyu Dai , Zhengwu Zhang , Anuj Srivastava

Over the years motor deficit in Parkinson's Disease (PD) patients was largely studied, however, no consistent pattern of relations between quantitative electroencephalography (qEEG) and motor scales emerged. There is a general lack of…

This study examines the utility of functional connectivity (FC) and graph-based (GB) measures with a support vector machine classifier for use in electroencephalogram (EEG) based biometrics. Although FC-based features have been used in…

Signal Processing · Electrical Eng. & Systems 2022-06-06 Pradeep Kumar G , Utsav Dutta , Kanishka Sharma , Ramakrishnan Angarai Ganesan

Parkinsons disease (PD) is a movement disorder and the second most common neurodengerative disease but despite its relative abundance, there are no clinically accepted neuroimaging biomarkers to make prognostic predictions or differentiate…

Neurons and Cognition · Quantitative Biology 2022-06-23 Cooper J. Mellema , Kevin P. Nguyen , Alex Treacher , Aixa Andrade Hernandez , Albert A. Montillo

Mobility is severely impacted in patients with Parkinson's disease (PD), especially when they experience involuntary stopping from the freezing of gait (FOG). Understanding the neurophysiological difference between "voluntary stopping" and…

This paper investigates prefrontal cortex (PFC) functional connectivity based on synchronized electrical and hemodynamic responses associated with mental stress. The electrical response was based on alpha rhythmic of Electroencephalography…

Neurons and Cognition · Quantitative Biology 2021-03-09 Fares Al-Shargie

Severe traumatic brain injury can lead to disorders of consciousness (DOC) characterized by deficit in conscious awareness and cognitive impairment including coma, vegetative state, minimally consciousness, and lock-in syndrome. Of crucial…

Neurons and Cognition · Quantitative Biology 2013-10-14 Verónica Mäki-Marttunen , Ibai Diez , Jesus M. Cortes , Dante R. Chialvo , Mirta Villarreal

Background: Dementia, particularly Alzheimer's Disease (AD), is a progressive neurodegenerative disorder marked by cognitive decline. Early detection, especially at the Mild Cognitive Impairment (MCI) stage, is essential for timely…

Signal Processing · Electrical Eng. & Systems 2025-10-16 Shivani Ranjan , Anant Jain , Robin Badal , Amit Kumar , Harshal Shende , Deepak Joshi , Pramod Yadav , Lalan Kumar

Parkinson's disease (PD) is a debilitating neurodegenerative disease that has severe impacts on an individual's quality of life. Compared with structural and functional MRI-based biomarkers for the disease, electroencephalography (EEG) can…

Machine Learning · Computer Science 2024-08-05 Christopher Neves , Yong Zeng , Yiming Xiao

Alzheimer's disease (AD) is a neurodegenerative disease known to affect brain functional connectivity (FC). Linear FC measures have been applied to study the differences in AD by splitting neurophysiological signals such as…

Neurons and Cognition · Quantitative Biology 2022-06-14 Dominik Klepl , Fei He , Min Wu , Daniel J. Blackburn , Ptolemaios G. Sarrigiannis

This paper studies change-points in human brain functional connectivity (FC) and seeks patterns that are common across multiple subjects under identical external stimulus. FC relates to the similarity of fMRI responses across different…

Neurons and Cognition · Quantitative Biology 2020-03-05 Mengyu Dai , Zhengwu Zhang , Anuj Srivastava

Measuring transient functional connectivity is an important challenge in Electroencephalogram (EEG) research. Here, the rich potential for insightful, discriminative information of brain activity offered by high temporal resolution is…

Neurons and Cognition · Quantitative Biology 2025-02-11 Om Roy , Yashar Moshfeghi , Agustin Ibanez , Francisco Lopera , Mario A Parra , Keith M Smith

This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis…

Functional connectivity (FC) has been widely used to study brain network interactions underlying the emerging cognition and behavior of an individual. FC is usually defined as the correlation or partial correlation between brain regions.…

Applications · Statistics 2020-10-27 Gemeng Zhang , Aiying Zhang , Biao Cai , Zhuozhuo Tu , Vince D. Calhoun , Yu-Ping Wang
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