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Artificial neurons built on synthetic gene networks have potential applications ranging from complex cellular decision-making to bioreactor regulation. Furthermore, due to the high information throughput of natural systems, it provides an…

Neural and Evolutionary Computing · Computer Science 2020-01-31 Sihao Huang

The success of recent deep convolutional neural networks (CNNs) depends on learning hidden representations that can summarize the important factors of variation behind the data. However, CNNs often criticized as being black boxes that lack…

Computer Vision and Pattern Recognition · Computer Science 2018-06-27 Bolei Zhou , David Bau , Aude Oliva , Antonio Torralba

Interpretability is crucial for ensuring RL systems align with human values. However, it remains challenging to achieve in complex decision making domains. Existing methods frequently attempt interpretability at the level of fundamental…

Machine Learning · Computer Science 2025-06-03 Anna Soligo , Pietro Ferraro , David Boyle

We formalize a novel modeling framework for achieving interpretability in deep learning, anchored in the principle of inference equivariance. While the direct verification of interpretability scales exponentially with the number of…

We present an interpretable neural network approach to predicting and understanding politeness in natural language requests. Our models are based on simple convolutional neural networks directly on raw text, avoiding any manual…

Computation and Language · Computer Science 2016-10-11 Malika Aubakirova , Mohit Bansal

We introduce and train distributed neural architectures (DNA) in vision and language domains. DNAs are initialized with a proto-architecture that consists of (transformer, MLP, attention, etc.) modules and routers. Any token (or patch) can…

Machine Learning · Computer Science 2025-06-30 Aditya Cowsik , Tianyu He , Andrey Gromov

Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex…

Biomolecules · Quantitative Biology 2021-02-02 Zichao Yan , William L. Hamilton , Mathieu Blanchette

Gradual argumentation frameworks represent arguments and their relationships in a weighted graph. Their graphical structure and intuitive semantics makes them a potentially interesting tool for interpretable machine learning. It has been…

Machine Learning · Computer Science 2021-06-28 Jonathan Spieler , Nico Potyka , Steffen Staab

Even though convolutional neural networks have become the method of choice in many fields of computer vision, they still lack interpretability and are usually designed manually in a cumbersome trial-and-error process. This paper aims at…

Computer Vision and Pattern Recognition · Computer Science 2019-12-12 Maria Ximena Bastidas Rodriguez , Adrien Gruson , Luisa F. Polania , Shin Fujieda , Flavio Prieto Ortiz , Kohei Takayama , Toshiya Hachisuka

While deep neural networks (DNN) have become an effective computational tool, the prediction results are often criticized by the lack of interpretability, which is essential in many real-world applications such as health informatics.…

Computer Vision and Pattern Recognition · Computer Science 2018-05-29 Mengnan Du , Ninghao Liu , Qingquan Song , Xia Hu

While deep neural networks (DNNs) have become a standard architecture for many machine learning tasks, their internal decision-making process and general interpretability is still poorly understood. Conversely, common decision trees are…

Machine Learning · Computer Science 2022-02-02 Coenraad Mouton , Marelie H. Davel

Deep learning is a topic of considerable current interest. The availability of massive data collections and powerful software resources has led to an impressive amount of results in many application areas that reveal essential but hidden…

Machine Learning · Computer Science 2023-01-31 Gianluigi Pillonetto , Aleksandr Aravkin , Daniel Gedon , Lennart Ljung , Antônio H. Ribeiro , Thomas B. Schön

Deep neural-network-based language models (LMs) are increasingly applied to large-scale protein sequence data to predict protein function. However, being largely black-box models and thus challenging to interpret, current protein LM…

Quantitative Methods · Quantitative Biology 2024-08-06 Mai Ha Vu , Rahmad Akbar , Philippe A. Robert , Bartlomiej Swiatczak , Victor Greiff , Geir Kjetil Sandve , Dag Trygve Truslew Haug

Graph neural networks trained to predict observable dynamics can be used to decompose the temporal activity of complex heterogeneous systems into simple, interpretable representations. Here we apply this framework to simulated neural…

Neurons and Cognition · Quantitative Biology 2026-02-17 Cédric Allier , Larissa Heinrich , Magdalena Schneider , Stephan Saalfeld

This paper proposes a new paradigm for learning a set of independent logical rules in disjunctive normal form as an interpretable model for classification. We consider the problem of learning an interpretable decision rule set as training a…

Machine Learning · Computer Science 2021-03-15 Litao Qiao , Weijia Wang , Bill Lin

Motif discovery is a powerful and insightful method to quantify network structures and explore their function. As a case study, we present a comprehensive analysis of regulatory motifs in the connectome of the model organism Caenorhabditis…

Molecular Networks · Quantitative Biology 2024-09-02 Deepak Sharma , Matthias Renz , Philipp Hövel

The ability of deep learning (DL) to improve the practice of medicine and its clinical outcomes faces a looming obstacle: model interpretation. Without description of how outputs are generated, a collaborating physician can neither resolve…

Machine Learning · Computer Science 2020-06-30 Christopher Snyder , Sriram Vishwanath

Though modern neural networks have achieved impressive performance in both vision and language tasks, we know little about the functions that they implement. One possibility is that neural networks implicitly break down complex tasks into…

Computation and Language · Computer Science 2023-11-08 Michael A. Lepori , Thomas Serre , Ellie Pavlick

Interpretable insights from predictive models remain critical in bio-statistics, particularly when assessing causality, where classical statistical and machine learning methods often provide inherent clarity. While Neural Networks (NNs)…

Applications · Statistics 2025-05-02 Jean-Baptiste A. Conan

Multivariate time series have many applications, from healthcare and meteorology to life science. Although deep learning models have shown excellent predictive performance for time series, they have been criticised for being "black-boxes"…

Machine Learning · Computer Science 2024-05-06 Qiqi Su , Christos Kloukinas , Artur d'Avila Garcez