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High-throughput technologies such as next generation sequencing allow biologists to observe cell function with unprecedented resolution, but the resulting datasets are too large and complicated for humans to understand without the aid of…

Applications · Statistics 2021-10-08 David S. Watson

Graph Nerual Networks (GNNs) are effective models in graph embedding. It extracts shallow features and neighborhood information by aggregating neighbor information to learn the embedding representation of different nodes. However, the local…

Social and Information Networks · Computer Science 2023-12-14 Kejia Zhang

The adoption of deep learning techniques in genomics has been hindered by the difficulty of mechanistically interpreting the models that these techniques produce. In recent years, a variety of post-hoc attribution methods have been proposed…

Molecular Networks · Quantitative Biology 2020-02-11 Ammar Tareen , Justin B. Kinney

Neural networks have greatly boosted performance in computer vision by learning powerful representations of input data. The drawback of end-to-end training for maximal overall performance are black-box models whose hidden representations…

Computer Vision and Pattern Recognition · Computer Science 2020-04-29 Patrick Esser , Robin Rombach , Björn Ommer

Motivated by the interpretability question in ML models as a crucial element for the successful deployment of AI systems, this paper focuses on rule extraction as a means for neural networks interpretability. Through a systematic literature…

Machine Learning · Computer Science 2023-12-21 Sara El Mekkaoui , Loubna Benabbou , Abdelaziz Berrado

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Neural networks are powerful function estimators, leading to their status as a paradigm of choice for modeling structured data. However, unlike other structured representations that emphasize the modularity of the problem -- e.g., factor…

Machine Learning · Computer Science 2022-06-20 Tsvetomila Mihaylova , Vlad Niculae , André F. T. Martins

We show a proof of principle for warping, a method to interpret the inner working of neural networks in the context of gene expression analysis. Warping is an efficient way to gain insight to the inner workings of neural nets and make them…

Genomics · Quantitative Biology 2017-08-17 Trofimov Assya , Lemieux Sebastien , Perreault Claude

Graph Neural Networks (GNNs) have emerged as the predominant approach for learning over graph-structured data. However, most GNNs operate as black-box models and require post-hoc explanations, which may not suffice in high-stakes scenarios…

Machine Learning · Computer Science 2025-10-14 Maya Bechler-Speicher , Amir Globerson , Ran Gilad-Bachrach

Self-explaining models are models that reveal decision making parameters in an interpretable manner so that the model reasoning process can be directly understood by human beings. General Linear Models (GLMs) are self-explaining because the…

Machine Learning · Computer Science 2019-05-31 Yingjing Lu , Runde Yang

Graphs can model complicated interactions between entities, which naturally emerge in many important applications. These applications can often be cast into standard graph learning tasks, in which a crucial step is to learn low-dimensional…

Machine Learning · Computer Science 2023-07-04 Xuexin Chen , Ruichu Cai , Yuan Fang , Min Wu , Zijian Li , Zhifeng Hao

Deformable image registration poses a challenging problem where, unlike most deep learning tasks, a complex relationship between multiple coordinate systems has to be considered. Although data-driven methods have shown promising…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Vasiliki Sideri-Lampretsa , Nil Stolt-Ansó , Huaqi Qiu , Julian McGinnis , Wenke Karbole , Martin Menten , Daniel Rueckert

The increasing use of complex machine learning models in education has led to concerns about their interpretability, which in turn has spurred interest in developing explainability techniques that are both faithful to the model's inner…

Machine Learning · Computer Science 2025-05-13 Juan D. Pinto , Luc Paquette

A deep generative model such as a GAN learns to model a rich set of semantic and physical rules about the target distribution, but up to now, it has been obscure how such rules are encoded in the network, or how a rule could be changed. In…

Computer Vision and Pattern Recognition · Computer Science 2020-07-31 David Bau , Steven Liu , Tongzhou Wang , Jun-Yan Zhu , Antonio Torralba

We propose a new interpretability method for neural networks, which is based on a novel mathematico-philosophical theory of reasons. Our method computes a vector for each neuron, called its reasons vector. We then can compute how strongly…

Machine Learning · Computer Science 2025-05-21 Levin Hornischer , Hannes Leitgeb

Deep learning is currently playing a crucial role toward higher levels of artificial intelligence. This paradigm allows neural networks to learn complex and abstract representations, that are progressively obtained by combining simpler…

Audio and Speech Processing · Electrical Eng. & Systems 2019-08-12 Mirco Ravanelli , Yoshua Bengio

Dense regions in networks are an indicator of interesting and unusual information. However, most existing methods only consider simple, undirected, unweighted networks. Complex networks in the real-world often have rich information though:…

Social and Information Networks · Computer Science 2021-03-08 Ahmet Erdem Sariyuce

When analyzing the genome, researchers have discovered that proteins bind to DNA based on certain patterns of the DNA sequence known as "motifs". However, it is difficult to manually construct motifs due to their complexity. Recently,…

Machine Learning · Computer Science 2017-02-23 Jack Lanchantin , Ritambhara Singh , Yanjun Qi

Graph neural networks (GNNs) are highly effective on a variety of graph-related tasks; however, they lack interpretability and transparency. Current explainability approaches are typically local and treat GNNs as black-boxes. They do not…

Machine Learning · Computer Science 2023-03-10 Han Xuanyuan , Pietro Barbiero , Dobrik Georgiev , Lucie Charlotte Magister , Pietro Lió

Language models' (LMs) proficiency in handling deterministic symbolic reasoning and rule-based tasks remains limited due to their dependency implicit learning on textual data. To endow LMs with genuine rule comprehension abilities, we…

Computation and Language · Computer Science 2024-03-12 Yixuan Weng , Minjun Zhu , Fei Xia , Bin Li , Shizhu He , Kang Liu , Jun Zhao