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We propose a methodology for estimating human behaviors in psychotherapy sessions using mutli-label and multi-task learning paradigms. We discuss the problem of behavioral coding in which data of human interactions is the annotated with…

Computation and Language · Computer Science 2020-10-07 James Gibson , David C. Atkins , Torrey Creed , Zac Imel , Panayiotis Georgiou , Shrikanth Narayanan

In medicine, treatments often influence multiple, interdependent outcomes, such as primary endpoints, complications, adverse events, or other secondary endpoints. Hence, to make optimal treatment decisions, clinicians are interested in…

Machine Learning · Computer Science 2025-06-03 Yuchen Ma , Jonas Schweisthal , Hengrui Zhang , Stefan Feuerriegel

Emotions recognition is commonly employed for health assessment. However, the typical metric for evaluation in therapy is based on patient-doctor appraisal. This process can fall into the issue of subjectivity, while also requiring…

Human-Computer Interaction · Computer Science 2021-01-21 Jumana Almahmoud , Kruthika Kikkeri

In the context of digital therapy interventions, such as internet-delivered Cognitive Behavioral Therapy (iCBT) for the treatment of depression and anxiety, extensive research has shown how the involvement of a human supporter or coach, who…

Human-Computer Interaction · Computer Science 2021-11-15 Anja Thieme

The Predictive Approaches to Treatment Effect Heterogeneity statement focused on baseline risk as a robust predictor of treatment effect and provided guidance on risk-based assessment of treatment effect heterogeneity in the RCT setting.…

In recent years, large language models have greatly improved in their ability to perform complex multi-step reasoning. However, even state-of-the-art models still regularly produce logical mistakes. To train more reliable models, we can…

Estimating individualised treatment effect (ITE) -- that is the causal effect of a set of variables (also called exposures, treatments, actions, policies, or interventions), referred to as \textit{composite treatments}, on a set of outcome…

Machine Learning · Computer Science 2025-12-19 Vinod Kumar Chauhan , Lei Clifton , Gaurav Nigam , David A. Clifton

The aim of clinical effectiveness research using repositories of electronic health records is to identify what health interventions 'work best' in real-world settings. Since there are several reasons why the net benefit of intervention may…

Methodology · Statistics 2020-06-19 Jie Zhu , Blanca Gallego

We develop a dependent Dirichlet process (DDP) model for repeated measures multiple membership (MM) data. This data structure arises in studies under which an intervention is delivered to each client through a sequence of elements which…

Applications · Statistics 2013-12-09 Terrance D. Savitsky , Susan M. Paddock

The rapid advancements in generative AI and large language models (LLMs) have opened up new avenues for producing synthetic data, particularly in the realm of structured tabular formats, such as product reviews. Despite the potential…

Machine Learning · Computer Science 2025-07-25 Yefeng Yuan , Yuhong Liu , Liang Cheng

The sequential treatment decisions made by physicians to treat chronic diseases are formalized in the statistical literature as dynamic treatment regimes. To date, methods for dynamic treatment regimes have been developed under the…

Methodology · Statistics 2022-02-22 Janie Coulombe , Erica E. M. Moodie , Susan M. Shortreed , Christel Renoux

Text-based conversational agents (CAs) are increasingly used in mental health, yet evaluation practices remain fragmented. We conducted a PRISMA-guided systematic review (May-June 2024) across ACM Digital Library, Scopus, and PsycINFO. From…

Human-Computer Interaction · Computer Science 2026-02-23 Jiangtao Gong , Xiao Wen , Fengyi Tao , Xinqi Wang , Xixi Yang , Yangrong Tang

In healthcare, AI techniques are widely used for tasks like risk assessment and anomaly detection. Despite AI's potential as a valuable assistant, its role in complex medical data analysis often oversimplifies human-AI collaboration…

Human-Computer Interaction · Computer Science 2024-07-23 Yang Ouyang , Chenyang Zhang , He Wang , Tianle Ma , Chang Jiang , Yuheng Yan , Zuoqin Yan , Xiaojuan Ma , Chuhan Shi , Quan Li

Instruction-based image editing has advanced rapidly, yet reliable and interpretable evaluation remains a bottleneck. Current protocols either (i) depend on paired reference images, resulting in limited coverage and inheriting biases from…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Tianyu Chen , Yasi Zhang , Zhi Zhang , Peiyu Yu , Shu Wang , Zhendong Wang , Kevin Lin , Xiaofei Wang , Zhengyuan Yang , Linjie Li , Chung-Ching Lin , Jianwen Xie , Oscar Leong , Lijuan Wang , Ying Nian Wu , Mingyuan Zhou

A platform trial with a master protocol provides an infrastructure to ethically and efficiently evaluate multiple treatment options in multiple diseases. Given that certain study drugs can enter or exit a platform trial, the randomization…

Methodology · Statistics 2025-07-15 Tianyu Zhan , Jane Zhang , Lei Shu , Yihua Gu

The call for patient-focused drug development is loud and clear, as expressed in the 21st Century Cures Act and in recent guidelines and initiatives of regulatory agencies. Among the factors contributing to modernized drug development and…

Client perceptions of the therapeutic alliance are critical for counseling effectiveness. Accurately capturing these perceptions remains challenging, as traditional post-session questionnaires are burdensome and often delayed, while…

Computation and Language · Computer Science 2026-02-25 Anqi Li , Chenxiao Wang , Yu Lu , Renjun Xu , Lizhi Ma , Zhenzhong Lan

Effective communication in serious illness and palliative care is essential but often under-taught due to limited access to training resources like standardized patients. We present PAL (Palliative Assisted Learning-bot), a conversational…

Human-Computer Interaction · Computer Science 2025-11-12 Neil K. R. Sehgal , Hita Kambhamettu , Allen Chang , Andrew Zhu , Lyle Ungar , Sharath Chandra Guntuku

We discuss MET, a learning-based algorithm proposed for perceiving a patient's level of engagement during telehealth sessions. We leverage latent vectors corresponding to Affective and Cognitive features frequently used in psychology…

Computer Vision and Pattern Recognition · Computer Science 2023-02-14 Pooja Guhan , Naman Awasthi , and Kathryn McDonald , Kristin Bussell , Dinesh Manocha , Gloria Reeves , Aniket Bera

In psychiatric diagnosis, a contemporary data-driven, manual-based method for mental disorders classification is the most popular technique; however, it has several inevitable flaws. Using the three-way decision as a framework, we propose a…

Artificial Intelligence · Computer Science 2023-04-11 Huidong Wang , Md Sakib Ullah Sourav , Mengdi Yang , Jiaping Zhang