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Early phase, personalized dose-finding trials for combination therapies seek to identify patient-specific optimal biological dose (OBD) combinations, which are defined as safe dose combinations which maximize therapeutic benefit for a…

Methodology · Statistics 2024-04-18 James Willard , Shirin Golchi , Erica EM Moodie

To optimize diffusion MRI acquisition protocols for IMPULSED model at clinical 3T scanner using Bayesian experimental design, enabling accurate cellular-scale parameter estimation under realistic scan time and scanner hardware constraints.…

Identification of optimal dose combinations in early phase dose-finding trials is challenging, due to the trade-off between precisely estimating the many parameters required to flexibly model the possibly non-monotonic dose-response…

Methodology · Statistics 2024-02-13 James Willard , Shirin Golchi , Erica E. M. Moodie , Bruno Boulanger , Bradley P. Carlin

Objective: Stroke is one of the leading causes of disabilities. One promising approach is to extend the rehabilitation with self-initiated robot-assisted movement therapy. To enable this, it is required to detect the patient's intention to…

Machine Learning · Computer Science 2026-01-09 Niklas Kueper , Kartik Chari , Elsa Andrea Kirchner

Trajectory optimization methods for motion planning attempt to generate trajectories that minimize a suitable objective function. Such methods efficiently find solutions even for high degree-of-freedom robots. However, a globally optimal…

Robotics · Computer Science 2019-07-18 Luka Petrović , Juraj Peršić , Marija Seder , Ivan Marković

Electromagnetic stimulation probes and modulates the neural systems that control movement. Key to understanding their effects is the muscle recruitment curve, which maps evoked potential size against stimulation intensity. Current methods…

We study the problem of causal discovery through targeted interventions. Starting from few observational measurements, we follow a Bayesian active learning approach to perform those experiments which, in expectation with respect to the…

Machine Learning · Statistics 2019-10-10 Julius von Kügelgen , Paul K Rubenstein , Bernhard Schölkopf , Adrian Weller

Rather than traditional position control, impedance control is preferred to ensure the safe operation of industrial robots programmed from demonstrations. However, variable stiffness learning studies have focused on task performance rather…

Robotics · Computer Science 2023-07-31 Masashi Okada , Mayumi Komatsu , Ryo Okumura , Tadahiro Taniguchi

Brain Electroencephalography (EEG) classification is widely applied to analyze cerebral diseases in recent years. Unfortunately, invalid/noisy EEGs degrade the diagnosis performance and most previously developed methods ignore the necessity…

Machine Learning · Computer Science 2018-02-12 Chenglong Dai , Jia Wu , Dechang Pi , Lin Cui

Walking controllers often require parametrization which must be tuned according to some cost function. To estimate these parameters, simulations can be performed which are cheap but do not fully represent reality. Real-robot experiments, on…

Robotics · Computer Science 2018-09-17 Diego Rodriguez , André Brandenburger , Sven Behnke

According to the theory of efficient coding, sensory systems are adapted to represent natural scenes with high fidelity and at minimal metabolic cost. Testing this hypothesis for sensory structures performing non-linear computations on high…

Neurons and Cognition · Quantitative Biology 2018-04-13 Ulisse Ferrari , Christophe Gardella , Olivier Marre , Thierry Mora

This paper presents a particle swarm optimizer for production of endurance time excitation functions. These excitations are intensifying acceleration time histories that are used as input motions in endurance time method. The accuracy of…

Signal Processing · Electrical Eng. & Systems 2019-11-01 Mohammadreza Mashayekhi , Mojtaba Harati , Homayoon E. Estekanchi

Objective: A major challenge in designing closed-loop brain-computer interfaces is finding optimal stimulation patterns as a function of ongoing neural activity for different subjects and objectives. Approach: To achieve goal-directed…

Neurons and Cognition · Quantitative Biology 2023-03-22 Matthew J. Bryan , Linxing Preston Jiang , Rajesh P N Rao

Machine Learning algorithms, such as Boosted Decisions Trees and Deep Neural Network, are widely used in High-Energy-Physics. The aim of this study is to apply Bayesian Optimization to tune the hyperparameters used in a machine learning…

Data Analysis, Statistics and Probability · Physics 2019-11-12 Oriel Kiss

Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) is widely used to study the reactivity and connectivity of brain regions for clinical or research purposes. The electromagnetic pulse of the TMS device…

Quantitative Methods · Quantitative Biology 2019-10-30 Panteleimon Vafeidis , Vasilios K. Kimiskidis , Dimitris Kugiumtzis

Knowing the correct skull conductivity is crucial for the accuracy of EEG source imaging, but unfortunately, its true value, which is inter- and intra-individually varying, is difficult to determine. In this paper, we propose a statistical…

Medical Physics · Physics 2020-09-07 Ville Rimpiläinen , Alexandra Koulouri , Felix Lucka , Jari P Kaipio , Carsten H Wolters

Simulations are a pedagogical means of enabling a risk-free way for healthcare practitioners to learn, maintain, or enhance their knowledge and skills. Such simulations should provide an optimum amount of cognitive load to the learner and…

Human-Computer Interaction · Computer Science 2020-02-05 Pritam Sarkar , Kyle Ross , Aaron J. Ruberto , Dirk Rodenburg , Paul Hungler , Ali Etemad

This paper proposes novel noise-free Bayesian optimization strategies that rely on a random exploration step to enhance the accuracy of Gaussian process surrogate models. The new algorithms retain the ease of implementation of the classical…

Machine Learning · Computer Science 2024-07-18 Hwanwoo Kim , Daniel Sanz-Alonso

Control algorithms such as model predictive control (MPC) and state estimators rely on a number of different parameters. The performance of the closed loop usually depends on the correct setting of these parameters. Tuning is often done…

Systems and Control · Electrical Eng. & Systems 2020-10-15 David Stenger , Muzaffer Ay , Dirk Abel

Autonomous experimentation (AE) combines machine learning and research hardware automation in a closed loop, guiding subsequent experiments toward user goals. As applied to materials research, AE can accelerate materials exploration,…

Materials Science · Physics 2023-06-21 Felix Adams , Austin McDannald , Ichiro Takeuchi , A. Gilad Kusne
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