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Online health resources and large language models (LLMs) are increasingly used as a first point of contact for medical decision-making, yet their reliability in healthcare remains limited by low accuracy, lack of transparency, and…

Artificial Intelligence · Computer Science 2026-04-22 Yujia Liu , Sophia Yu , Hongyue Jin , Jessica Wen , Alexander Qian , Terrence Lee , Mattheus Ramsis , Gi Won Choi , Lianhui Qin , Xin Liu , Edward J. Wang

Large language models (LLMs) have immense potential to make information more accessible, particularly in medicine, where complex medical jargon can hinder patient comprehension of clinical notes. We developed a patient-facing tool using…

The implementation of Artificial Intelligence (AI) in the healthcare industry has garnered considerable attention, attributable to its prospective enhancement of clinical outcomes, expansion of access to superior healthcare, cost reduction,…

Computation and Language · Computer Science 2024-08-23 Arindam Sett , Somaye Hashemifar , Mrunal Yadav , Yogesh Pandit , Mohsen Hejrati

Large language models (LLMs) have demonstrated remarkable capabilities in handling complex dialogue tasks without requiring use case-specific fine-tuning. However, analyzing live dialogues in real-time necessitates low-latency processing…

Computation and Language · Computer Science 2025-03-10 Xuanqing Liu , Luyang Kong , Wei Niu , Afshin Khashei , Belinda Zeng , Steve Johnson , Jon Jay , Davor Golac , Matt Pope

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

Large Language Models (LLMs) acquire extensive knowledge and remarkable abilities from extensive text corpora, making them powerful tools for various applications. To make LLMs more usable, aligning them with human preferences is essential.…

Computation and Language · Computer Science 2024-10-21 Mozhi Zhang , Pengyu Wang , Chenkun Tan , Mianqiu Huang , Dong Zhang , Yaqian Zhou , Xipeng Qiu

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

The integration of voice-based AI agents in healthcare presents a transformative opportunity to bridge economic and accessibility gaps in digital health delivery. This paper explores the role of large language model (LLM)-powered voice…

Artificial Intelligence · Computer Science 2025-07-28 Bo Wen , Chen Wang , Qiwei Han , Raquel Norel , Julia Liu , Thaddeus Stappenbeck , Jeffrey L. Rogers

As large language models (LLMs) become integral to intelligent user interfaces (IUIs), their role as decision-making agents raises critical concerns about alignment. Although extensive research has addressed issues such as factuality, bias,…

Artificial Intelligence · Computer Science 2025-04-23 Anna Karnysheva , Christian Drescher , Dietrich Klakow

LLMs are popular among clinicians for decision-support because of simple text-based interaction. However, their impact on clinicians' performance is ambiguous. Not knowing how clinicians use this new technology and how they compare it to…

Human-Computer Interaction · Computer Science 2026-02-02 Behnam Rahdari , Sameer Shaikh , Jonathan H Chen , Tobias Gerstenberg , Shriti Raj

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Large Language Model (LLM)-based agents have demonstrated strong capabilities across a wide range of tasks, and their application in the medical domain holds particular promise due to the demand for high generalizability and reliance on…

Artificial Intelligence · Computer Science 2025-08-18 Yangyang Zhuang , Wenjia Jiang , Jiayu Zhang , Ze Yang , Joey Tianyi Zhou , Chi Zhang

Although large language models perform well in understanding and responding to user intent, their performance in specialized domains such as Traditional Chinese Medicine (TCM) remains limited due to lack of expertise. In addition,…

Computation and Language · Computer Science 2024-11-05 Song Yu , Xiaofei Xu , Fangfei Xu , Li Li

Congenital heart disease (CHD) presents complex, lifelong challenges often underrepresented in traditional clinical metrics. While unstructured narratives offer rich insights into patient and caregiver experiences, manual thematic analysis…

Computation and Language · Computer Science 2025-08-12 Seungjun Yi , Joakim Nguyen , Huimin Xu , Terence Lim , Andrew Well , Mia Markey , Ying Ding

Large language models (LLMs) increasingly serve as the central control unit of AI agents, yet current approaches remain limited in their ability to deliver personalized interactions. While Retrieval Augmented Generation enhances LLM…

Artificial Intelligence · Computer Science 2025-10-10 Rebecca Westhäußer , Wolfgang Minker , Sebatian Zepf

Reinforcement Learning from Human Feedback (RLHF) has become a pivotal paradigm in artificial intelligence to align large models with human preferences. In this paper, we propose a novel statistical framework to simultaneously conduct the…

Machine Learning · Statistics 2026-05-01 Nan Lu , Ethan Lee , Ethan X. Fang , Junwei Lu

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

Aligning large language models (LLMs) with human preferences has proven to drastically improve usability and has driven rapid adoption as demonstrated by ChatGPT. Alignment techniques such as supervised fine-tuning (SFT) and reinforcement…

Large Language Models (LLMs) have become a popular interface for human-AI interaction, supporting information seeking and task assistance through natural, multi-turn dialogue. To respond to users within multi-turn dialogues, the…

Computation and Language · Computer Science 2026-04-16 Fengran Mo , Yifan Gao , Sha Li , Hansi Zeng , Xin Liu , Zhaoxuan Tan , Xian Li , Jianshu Chen , Dakuo Wang , Meng Jiang

Reward design has been one of the central challenges for real world reinforcement learning (RL) deployment, especially in settings with multiple objectives. Preference-based RL offers an appealing alternative by learning from human…

Artificial Intelligence · Computer Science 2026-02-25 Chenyang Zhao , Vinny Cahill , Ivana Dusparic