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Mediation analysis with contemporaneously observed multiple mediators is an important area of causal inference. Recent approaches for multiple mediators are often based on parametric models and thus may suffer from model misspecification.…

Methodology · Statistics 2022-08-30 Samrat Roy , Michael J. Daniels , Brendan J. Kelly , Jason Roy

Testing whether a probability distribution is compatible with a given Bayesian network is a fundamental task in the field of causal inference, where Bayesian networks model causal relations. Here we consider the class of causal structures…

Machine Learning · Statistics 2020-09-04 Aditya Kela , Kai von Prillwitz , Johan Aberg , Rafael Chaves , David Gross

Nosocomial infections have important consequences for patients and hospital staff: they worsen patient outcomes and their management stresses already overburdened health systems. Accurate judgements of whether an infection is nosocomial…

We present a Bayesian mixture model for estimating the joint distribution of mixed ordinal, nominal, and continuous data conditional on a set of fixed variables. The model uses multivariate normal and categorical mixture kernels for the…

Methodology · Statistics 2016-07-14 Maria DeYoreo , Jerome P. Reiter

Graph-based machine learning methods are useful tools in the identification and prediction of variation in genetic data. In particular, the comprehension of phenotypic effects at the cellular level is an accelerating research area in…

Quantitative Methods · Quantitative Biology 2024-12-06 Nandini Gadhia , Michalis Smyrnakis , Po-Yu Liu , Damer Blake , Melanie Hay , Anh Nguyen , Dominic Richards , Dong Xia , Ritesh Krishna

When modelling HIV epidemics, it is important to incorporate set-point viral load and its heritability. As set-point viral load distributions can differ significantly amongst epidemics, it is imperative to account for the observed local…

Populations and Evolution · Quantitative Biology 2018-11-28 Pieter Libin , Laurens Hernalsteen , Kristof Theys , Perpetua Gomes , Ana Abecasis , Ann Nowe

This research is about studying and comparing two different ways of building complex networks. The main goal of our study is to find an effective way to build networks, particularly when we have fewer observations than variables. We…

Methodology · Statistics 2014-09-10 Lina D. Thomas , Victor Fossaluza , Anatoly Yambartsev

In the last decade, stochastic models have shown to be very useful for quantitative modelling of social processes. Here, a configurational master equation for the description of behavioral changes by pair interactions of individuals is…

Statistical Mechanics · Physics 2009-10-31 Dirk Helbing

Research in Cognitive Science suggests that humans understand and represent knowledge of the world through causal relationships. In addition to observations, they can rely on experimenting and counterfactual reasoning -- i.e. referring to…

Artificial Intelligence · Computer Science 2021-05-24 Kanvaly Fadiga , Etienne Houzé , Ada Diaconescu , Jean-Louis Dessalles

Statistical inference using pairwise comparison data is an effective approach to analyzing large-scale sparse networks. In this paper, we propose a general framework to model the mutual interactions in a network, which enjoys ample…

Machine Learning · Statistics 2022-03-11 Ruijian Han , Yiming Xu , Kani Chen

Structural changes in a network representation of a system (e.g.,different experimental conditions, time evolution), can provide insight on its organization, function and on how it responds to external perturbations. The deeper…

Data Analysis, Statistics and Probability · Physics 2021-01-04 Leonardo L. Portes , Michael Small

An important part of the analysis of bio-molecular networks is to detect different functional units. Different functions are reflected in a different evolutionary dynamics, and hence in different statistical characteristics of network…

Molecular Networks · Quantitative Biology 2007-05-23 Johannes Berg , Michael Lässig

Replicated network data are increasingly available in many research fields. In connectomic applications, inter-connections among brain regions are collected for each patient under study, motivating statistical models which can flexibly…

Methodology · Statistics 2018-09-11 Daniele Durante , David B. Dunson , Joshua T. Vogelstein

Graphical models are ubiquitous tools to describe the interdependence between variables measured simultaneously such as large-scale gene or protein expression data. Gaussian graphical models (GGMs) are well-established tools for…

Methodology · Statistics 2020-01-09 Nilabja Guha , Veera Baladandayuthapani , Bani K. Mallick

A new method is developed to represent probabilistic relations on multiple random events. Where previously knowledge bases containing probabilistic rules were used for this purpose, here a probability distribution over the relations is…

Artificial Intelligence · Computer Science 2013-02-08 Manfred Jaeger

In this paper we introduce a novel Bayesian approach for linking multiple social networks in order to discover the same real world person having different accounts across networks. In particular, we develop a latent model that allow us to…

Applications · Statistics 2018-08-15 Juan Sosa , Abel Rodriguez

Here we introduce a new design framework for synthetic biology that exploits the advantages of Bayesian model selection. We will argue that the difference between inference and design is that in the former we try to reconstruct the system…

Molecular Networks · Quantitative Biology 2015-05-27 Chris Barnes , Daniel Silk , Xia Sheng , Michael P. H. Stumpf

We address the problem of two-variable causal inference without intervention. This task is to infer an existing causal relation between two random variables, i.e. $X \rightarrow Y$ or $Y \rightarrow X$ , from purely observational data. As…

Machine Learning · Statistics 2020-01-07 Maximilian Kurthen , Torsten A. Enßlin

Reconstructing transmission networks is essential for identifying key factors like superspreaders and high-risk locations, which are critical for developing effective pandemic prevention strategies. In this study, we developed a Bayesian…

Quantitative Methods · Quantitative Biology 2024-09-10 Jianing Xu , Huimin Hu , Gregory Ellison , Lili Yu , Christopher Whalen , Liang Liu

Gaussian graphical models have been used to study intrinsic dependence among several variables, but the Gaussianity assumption may be restrictive in many applications. A nonparanormal graphical model is a semiparametric generalization for…

Methodology · Statistics 2020-05-20 Jami J. Mulgrave , Subhashis Ghosal
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