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Large Language Models (LLMs) create exciting possibilities for powerful language processing tools to accelerate research in materials science. While LLMs have great potential to accelerate materials understanding and discovery, they…

Materials Science · Physics 2024-09-26 Santiago Miret , N M Anoop Krishnan

Large language models (LLMs) are increasingly tasked with generating structured outputs. While structured generation methods ensure validity, they often lack output diversity, a critical limitation that we confirm in our preliminary study.…

Computation and Language · Computer Science 2025-11-17 Xiaokun Luan , Zeming Wei , Yihao Zhang , Meng Sun

Multimodal large language models (MLLMs) have made impressive progress in many applications in recent years. However, chemical MLLMs that can handle cross-modal understanding and generation remain underexplored. To fill this gap, we propose…

Machine Learning · Computer Science 2025-08-05 Qian Tan , Dongzhan Zhou , Peng Xia , Wanhao Liu , Wanli Ouyang , Lei Bai , Yuqiang Li , Tianfan Fu

Recently, large language models (LLMs) have shown significant progress, approaching human perception levels. In this work, we demonstrate that despite these advances, LLMs still struggle to reason using molecular structural information.…

Machine Learning · Computer Science 2025-05-26 Yunhui Jang , Jaehyung Kim , Sungsoo Ahn

Language models (LMs) have exhibited impressive abilities in generating code from natural language requirements. In this work, we highlight the diversity of code generated by LMs as a critical criterion for evaluating their code generation…

Software Engineering · Computer Science 2025-03-10 Seonghyeon Lee , Heejae Chon , Joonwon Jang , Dongha Lee , Hwanjo Yu

In the past year, Generative Recommendations (GRs) have undergone substantial advancements, especially in leveraging the powerful sequence modeling and reasoning capabilities of Large Language Models (LLMs) to enhance overall recommendation…

Information Retrieval · Computer Science 2025-07-15 Zhen Yang , Haitao Lin , Jiawei xue , Ziji Zhang

The development of large language models and multi-modal models has enabled the appealing idea of generating novel molecules from text descriptions. Generative modeling would shift the paradigm from relying on large-scale chemical screening…

Machine Learning · Computer Science 2025-08-25 Yifan Deng , Spencer S. Ericksen , Anthony Gitter

It has long been recognized that it is not enough for a Recommender System (RS) to provide recommendations based only on their relevance to users. Among many other criteria, the set of recommendations may need to be diverse. Diversity is…

Information Retrieval · Computer Science 2024-06-19 Diego Carraro , Derek Bridge

Access to large amounts of diverse design solutions can support designers during the early stage of the design process. In this paper, we explore the efficacy of large language models (LLM) in producing diverse design solutions,…

Human-Computer Interaction · Computer Science 2024-05-07 Kevin Ma , Daniele Grandi , Christopher McComb , Kosa Goucher-Lambert

Retrosynthesis, the process of breaking down a target molecule into simpler precursors through a series of valid reactions, stands at the core of organic chemistry and drug development. Although recent machine learning (ML) research has…

Artificial Intelligence · Computer Science 2026-05-12 Haorui Wang , Jeff Guo , Lingkai Kong , Rampi Ramprasad , Philippe Schwaller , Yuanqi Du , Chao Zhang

Large Language Models (LLMs) represent a class of deep learning models adept at understanding natural language and generating coherent responses to various prompts or queries. These models far exceed the complexity of conventional neural…

Machine Learning · Computer Science 2024-12-05 Minghao Shao , Abdul Basit , Ramesh Karri , Muhammad Shafique

Large Language Models (LLMs) have demonstrated great promise in generating code, especially when used inside an evolutionary computation framework to iteratively optimize the generated algorithms. However, in some cases they fail to…

Neural and Evolutionary Computing · Computer Science 2025-03-24 Niki van Stein , Anna V. Kononova , Lars Kotthoff , Thomas Bäck

The usage of Large Language Models (LLMs) for software and test development has continued to increase since LLMs were first introduced, but only recently have the expectations of LLMs become more realistic. Verifying the correctness of code…

Software Engineering · Computer Science 2025-08-20 Zachariah Sollenberger , Rahul Patel , Saieda Ali Zada , Sunita Chandrasekaran

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Computation and Language · Computer Science 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

The development and evaluation of Large Language Models (LLMs) has primarily focused on their task-solving capabilities, with recent models even surpassing human performance in some areas. However, this focus often neglects whether…

Computation and Language · Computer Science 2025-07-29 Yanzhu Guo , Guokan Shang , Chloé Clavel

Large Language Models (LLMs) employ three popular training approaches: Masked Language Models (MLM), Causal Language Models (CLM), and Sequence-to-Sequence Models (seq2seq). However, each approach has its strengths and limitations, and…

Machine Learning · Computer Science 2025-02-18 Xuefeng Liu , Songhao Jiang , Bo Li , Rick Stevens

Large language models (LLMs) have demonstrated broad utility across molecular domains, spanning drug discovery and materials design. Analyzing LLMs' latent representations is crucial for elucidating their underlying mechanisms, improving…

Machine Learning · Computer Science 2026-02-03 Zhuoran Li , Xu Sun , Wanyu Lin , Jiannong Cao

The ability of large language models to generate complex texts allows them to be widely integrated into many aspects of life, and their output can quickly fill all network resources. As the impact of LLMs grows, it becomes increasingly…

Computation and Language · Computer Science 2024-11-12 Yongye Su , Yuqing Wu

There is a significant potential for coding skills to transition fully to natural language in the future. In this context, large language models (LLMs) have shown impressive natural language processing abilities to generate sophisticated…

Materials Science · Physics 2024-06-25 Prathamesh Satpute , Saurabh Tiwari , Maneet Gupta , Supriyo Ghosh

Large Language Models (LLMs) have demonstrated their transformative potential across numerous disciplinary studies, reshaping the existing research methodologies and fostering interdisciplinary collaboration. However, a systematic…

Computation and Language · Computer Science 2025-07-14 Lu Xiang , Yang Zhao , Yaping Zhang , Chengqing Zong