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Positron emission tomography (PET) is a key nuclear medicine imaging modality that visualizes radiotracer distributions to quantify in vivo physiological and metabolic processes, playing an irreplaceable role in disease management. Despite…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Yichi Zhang , Le Xue , Wenbo Zhang , Lanlan Li , Feiyang Xiao , Yuchen Liu , Xiaohui Zhang , Hongwei Zhang , Shuqi Wang , Gang Feng , Liling Peng , Xin Gao , Yuanfan Xu , Yuan Qi , Kuangyu Shi , Hong Zhang , Yuan Cheng , Mei Tian , Zixin Hu

Automatic segmentation of tumor lesions is a critical initial processing step for quantitative PET/CT analysis. However, numerous tumor lesions with different shapes, sizes, and uptake intensity may be distributed in different anatomical…

Image and Video Processing · Electrical Eng. & Systems 2022-09-20 Zhantao Liu , Shaonan Zhong , Junyang Mo

Tumor segmentation in PET-CT images is challenging due to the dual nature of the acquired information: low metabolic information in CT and low spatial resolution in PET. U-Net architecture is the most common and widely recognized approach…

Image and Video Processing · Electrical Eng. & Systems 2022-10-06 Simone Bendazzoli , Mehdi Astaraki

Positron Emission Tomography (PET) is a powerful molecular imaging tool that plays a crucial role in modern medical diagnostics by visualizing radio-tracer distribution to reveal physiological processes. Accurate organ segmentation from PET…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Yichi Zhang , Le Xue , Wenbo Zhang , Lanlan Li , Yuchen Liu , Chen Jiang , Yuan Cheng , Yuan Qi

Tumor segmentation in medical imaging is crucial and relies on precise delineation. Fluorodeoxyglucose Positron-Emission Tomography (FDG-PET) is widely used in clinical practice to detect metabolically active tumors. However, FDG-PET scans…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Matthias Hadlich , Zdravko Marinov , Rainer Stiefelhagen

Automatic segmentation of lesions in FDG-18 Whole Body (WB) PET/CT scans using deep learning models is instrumental for determining treatment response, optimizing dosimetry, and advancing theranostic applications in oncology. However, the…

Image and Video Processing · Electrical Eng. & Systems 2023-11-06 Gowtham Krishnan Murugesan , Diana McCrumb , Eric Brunner , Jithendra Kumar , Rahul Soni , Vasily Grigorash , Stephen Moore , Jeff Van Oss

This study explores a workflow for automated segmentation of lesions in FDG and PSMA PET/CT images. Due to the substantial differences in image characteristics between FDG and PSMA, specialized preprocessing steps are required. Utilizing…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Qiaoyi Xue , Youdan Feng , Jiayi Liu , Tianming Xu , Kaixin Shen , Chuyun Shen , Yuhang Shi

Tumor lesion segmentation is one of the most important tasks in medical image analysis. In clinical practice, Fluorodeoxyglucose Positron-Emission Tomography~(FDG-PET) is a widely used technique to identify and quantify metabolically active…

Image and Video Processing · Electrical Eng. & Systems 2022-10-17 Jin Ye , Haoyu Wang , Ziyan Huang , Zhongying Deng , Yanzhou Su , Can Tu , Qian Wu , Yuncheng Yang , Meng Wei , Jingqi Niu , Junjun He

Tumor volume and changes in tumor characteristics over time are important biomarkers for cancer therapy. In this context, FDG-PET/CT scans are routinely used for staging and re-staging of cancer, as the radiolabeled fluorodeoxyglucose is…

Accurate segmentation of lesions in longitudinal whole-body CT is essential for monitoring disease progression and treatment response. While automated methods benefit from incorporating longitudinal information, they remain limited in their…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Yannick Kirchhoff , Maximilian Rokuss , Fabian Isensee , Klaus H. Maier-Hein

This study addresses critical gaps in automated lymphoma segmentation from PET/CT images, focusing on issues often overlooked in existing literature. While deep learning has been applied for lymphoma lesion segmentation, few studies…

Recent advances in automated skin cancer diagnosis have yielded performance on par with board-certified dermatologists. However, these approaches formulated skin cancer diagnosis as a simple classification task, dismissing the potential…

Image and Video Processing · Electrical Eng. & Systems 2021-12-06 Jingye Chen , Jieneng Chen , Zongwei Zhou , Bin Li , Alan Yuille , Yongyi Lu

Fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with computed tomography (CT) is considered the primary solution for detecting some cancers, such as lung cancer and melanoma. Automatic segmentation of tumors in PET/CT…

Image and Video Processing · Electrical Eng. & Systems 2023-09-15 Linghan Cai , Jianhao Huang , Zihang Zhu , Jinpeng Lu , Yongbing Zhang

Cancer is one of the leading causes of death globally, and early diagnosis is crucial for patient survival. Deep learning algorithms have great potential for automatic cancer analysis. Artificial intelligence has achieved high performance…

Image and Video Processing · Electrical Eng. & Systems 2024-04-16 Monika Górka , Daniel Jaworek , Marek Wodzinski

The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET…

The accurate segmentation of lesions in whole-body PET/CT imaging is es-sential for tumor characterization, treatment planning, and response assess-ment, yet current manual workflows are labor-intensive and prone to inter-observer…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Moona Mazher , Steven A Niederer , Abdul Qayyum

Accurate lesion segmentation in whole-body PET/CT scans is crucial for cancer diagnosis and treatment planning, but limited datasets often hinder the performance of automated segmentation models. In this paper, we explore the potential of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Lap Yan Lennon Chan , Chenxin Li , Yixuan Yuan

Towards automated retinal screening, this paper makes an endeavor to simultaneously achieve pixel-level retinal lesion segmentation and image-level disease classification. Such a multi-task approach is crucial for accurate and clinically…

Computer Vision and Pattern Recognition · Computer Science 2020-10-20 Qijie Wei , Xirong Li , Weihong Yu , Xiao Zhang , Yongpeng Zhang , Bojie Hu , Bin Mo , Di Gong , Ning Chen , Dayong Ding , Youxin Chen

PET imaging is an invaluable tool in clinical settings as it captures the functional activity of both healthy anatomy and cancerous lesions. Developing automatic lesion segmentation methods for PET images is crucial since manual lesion…

Image and Video Processing · Electrical Eng. & Systems 2024-11-05 Tanya Gatsak , Kumar Abhishek , Hanene Ben Yedder , Saeid Asgari Taghanaki , Ghassan Hamarneh

Artificial intelligence (AI) techniques for image-based segmentation have garnered much attention in recent years. Convolutional neural networks (CNNs) have shown impressive results and potential towards fully automated segmentation in…

Medical Physics · Physics 2021-11-17 Fereshteh Yousefirizi , Abhinav K. Jha , Julia Brosch-Lenz , Babak Saboury , Arman Rahmim