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Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is a common solution for working with high resolution…

Whole Slide Image (WSI) classification has very significant applications in clinical pathology, e.g., tumor identification and cancer diagnosis. Currently, most research attention is focused on Multiple Instance Learning (MIL) using static…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Jiaxiang Gou , Luping Ji , Pei Liu , Mao Ye

This paper presents an autoencoder-based neural network architecture to compress histopathological images while retaining the denser and more meaningful representation of the original images. Current research into improving compression…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 Agnes Barsi , Suvendu Chandan Nayak , Sasmita Parida , Raj Mani Shukla

Masked image modeling (MIM) has attracted much research attention due to its promising potential for learning scalable visual representations. In typical approaches, models usually focus on predicting specific contents of masked patches,…

Computer Vision and Pattern Recognition · Computer Science 2023-04-13 Haochen Wang , Kaiyou Song , Junsong Fan , Yuxi Wang , Jin Xie , Zhaoxiang Zhang

The fine-grained annotations in whole slide images (WSIs) show the boundaries of various pathological regions. However, generating such detailed annotation is often costly, whereas the coarse annotations are relatively simpler to produce.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Bingjian Yao , Weiping Lin , Yan He , Zheng Wang , Liangsheng Wang

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Whole-slide image analysis is essential for diagnostic tasks in pathology, yet existing deep learning methods primarily rely on flat classification, ignoring hierarchical relationships among class labels. In this study, we propose HiClass,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Keunho Byeon , Jinsol Song , Seong Min Hong , Yosep Chong , Jin Tae Kwak

Trained using only image class label, deep weakly supervised methods allow image classification and ROI segmentation for interpretability. Despite their success on natural images, they face several challenges over histology data where ROI…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Semi-Supervised Learning (SSL) can leverage abundant unlabeled data to boost model performance. However, the class-imbalanced data distribution in real-world scenarios poses great challenges to SSL, resulting in performance degradation.…

Computer Vision and Pattern Recognition · Computer Science 2025-01-13 Yin Wang , Zixuan Wang , Hao Lu , Zhen Qin , Hailiang Zhao , Guanjie Cheng , Ge Su , Li Kuang , Mengchu Zhou , Shuiguang Deng

Using features extracted from networks pretrained on ImageNet is a common practice in applications of deep learning for digital pathology. However it presents the downside of missing domain specific image information. In digital pathology,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Jacob Gildenblat , Eldad Klaiman

Multiple instance learning (MIL) can reduce the need for costly annotation in tasks such as semantic segmentation by weakening the required degree of supervision. We propose a novel MIL formulation of multi-class semantic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2015-04-16 Deepak Pathak , Evan Shelhamer , Jonathan Long , Trevor Darrell

Recently, pathological diagnosis has achieved superior performance by combining deep learning models with the multiple instance learning (MIL) framework using whole slide images (WSIs). However, the giga-pixeled nature of WSIs poses a great…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Zijie Fang , Yifeng Wang , Ye Zhang , Zhi Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang

Tumor segmentation stands as a pivotal task in cancer diagnosis. Given the immense dimensions of whole slide images (WSI) in histology, deep learning approaches for WSI classification mainly operate at patch-wise or superpixel-wise level.…

Computer Vision and Pattern Recognition · Computer Science 2024-02-22 Huaqian Wu , Clara Brémond-Martin , Kévin Bouaou , Cédric Clouchoux

Precise identification of multiple cell classes in high-resolution Giga-pixel whole slide imaging (WSI) is critical for various clinical scenarios. Building an AI model for this purpose typically requires pixel-level annotations, which are…

Image and Video Processing · Electrical Eng. & Systems 2023-08-14 Xueyuan Li , Ruining Deng , Yucheng Tang , Shunxing Bao , Haichun Yang , Yuankai Huo

With the development of computational pathology, deep learning methods for Gleason grading through whole slide images (WSIs) have excellent prospects. Since the size of WSIs is extremely large, the image label usually contains only…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Hao Bian , Zhuchen Shao , Yang Chen , Yifeng Wang , Haoqian Wang , Jian Zhang , Yongbing Zhang

This paper proposes a novel method of classifying malware into families using high-resolution greyscale images and multiple instance learning to overcome adversarial binary enlargement. Current methods of visualisation-based malware…

Cryptography and Security · Computer Science 2023-11-22 Tim Peters , Hikmat Farhat

Weakly supervised semantic segmentation (WSSS) has gained significant popularity since it relies only on weak labels such as image level annotations rather than pixel level annotations required by supervised semantic segmentation (SSS)…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Kunhao Yuan , Gerald Schaefer , Yu-Kun Lai , Yifan Wang , Xiyao Liu , Lin Guan , Hui Fang

Delineation of cancerous regions in gigapixel whole slide images (WSIs) is a crucial diagnostic procedure in digital pathology. This process is time-consuming because of the large search space in the gigapixel WSIs, causing chances of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Hsien-Tzu Cheng , Chun-Fu Yeh , Po-Chen Kuo , Andy Wei , Keng-Chi Liu , Mong-Chi Ko , Kuan-Hua Chao , Yu-Ching Peng , Tyng-Luh Liu

Weakly supervised instance labeling using only image-level labels, in lieu of expensive fine-grained pixel annotations, is crucial in several applications including medical image analysis. In contrast to conventional instance segmentation…

Computer Vision and Pattern Recognition · Computer Science 2019-07-31 Jayaraman J. Thiagarajan , Satyananda Kashyap , Alexandros Karagyris

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta
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