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An important feature of successful supervised machine learning applications is to be able to explain the predictions given by the regression or classification model being used. However, most state-of-the-art models that have good predictive…

Machine Learning · Statistics 2019-10-14 Victor Coscrato , Marco Henrique de Almeida Inácio , Tiago Botari , Rafael Izbicki

This manuscript proposes a novel methodology for developing an interpretable prediction model for irregular Electrocardiogram (ECG) classification, using features extracted by a 1-D Deconvolutional Neural Network (1-D DNN). Given the…

Applications · Statistics 2024-10-17 Giacomo Lancia , Cristian Spitoni

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

Fairness of machine learning models in healthcare has drawn increasing attention from clinicians, researchers, and even at the highest level of government. On the other hand, the importance of developing and deploying interpretable or…

Machine Learning · Computer Science 2024-09-04 Mary M. Lucas , Xiaoyang Wang , Chia-Hsuan Chang , Christopher C. Yang , Jacqueline E. Braughton , Quyen M. Ngo

The ``black-box'' nature of deep learning models presents a significant barrier to their adoption for scientific discovery, where interpretability is paramount. This challenge is especially pronounced in discovering the governing equations…

Machine Learning · Computer Science 2025-08-26 Riccardo Cappi , Paolo Frazzetto , Nicolò Navarin , Alessandro Sperduti

Clinical AI adoption is hindered by the black-box/grey-box nature of high-performing models, which lack the ontological grounding and narrative transparency required for professional-level explainability. We present NEURON, a neuro-symbolic…

Artificial Intelligence · Computer Science 2026-05-05 Anuradha Chandrasekaran , Dimitrios Zikos , Mutlu Mete , Alan Pang , Brady D. Lund , Kewei Sha

Dementia is a progressive neurodegenerative disorder with multiple etiologies, including Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and vascular dementia. Its clinical and biological heterogeneity makes diagnosis and…

Machine Learning · Computer Science 2025-09-24 Niharika Tewari , Nguyen Linh Dan Le , Mujie Liu , Jing Ren , Ziqi Xu , Tabinda Sarwar , Veeky Baths , Feng Xia

Recent efforts in Machine Learning (ML) interpretability have focused on creating methods for explaining black-box ML models. However, these methods rely on the assumption that simple approximations, such as linear models or decision-trees,…

Machine Learning · Computer Science 2019-06-13 Owen Lahav , Nicholas Mastronarde , Mihaela van der Schaar

The increasing global prevalence of mental disorders, such as depression and PTSD, requires objective and scalable diagnostic tools. Traditional clinical assessments often face limitations in accessibility, objectivity, and consistency.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-03 Abdelrahaman A. Hassan , Abdelrahman A. Ali , Aya E. Fouda , Radwa J. Hanafy , Mohammed E. Fouda

Recent progress in deep reinforcement learning (DRL) can be largely attributed to the use of neural networks. However, this black-box approach fails to explain the learned policy in a human understandable way. To address this challenge and…

Artificial Intelligence · Computer Science 2021-03-17 Zhihao Ma , Yuzheng Zhuang , Paul Weng , Hankz Hankui Zhuo , Dong Li , Wulong Liu , Jianye Hao

Diabetes mellitus (DM) is a global health issue of significance that must be diagnosed as early as possible and managed well. This study presents a framework for diabetes prediction using Machine Learning (ML) models, complemented with…

Machine Learning · Computer Science 2025-02-13 Pir Bakhsh Khokhar , Viviana Pentangelo , Fabio Palomba , Carmine Gravino

Biomedical research has revealed the crucial role of miRNAs in the progression of many diseases, and computational prediction methods are increasingly proposed for assisting biological experiments to verify miRNA-disease associations…

Computational Engineering, Finance, and Science · Computer Science 2023-08-29 Yi Zhou , Meixuan Wu , Chengzhou Ouyang , Min Zhu

Scientific modeling faces a tradeoff between the interpretability of mechanistic theory and the predictive power of machine learning. While existing hybrid approaches have made progress by incorporating domain knowledge into machine…

Machine Learning · Computer Science 2026-04-15 Carson Dudley , Reiden Magdaleno , Christopher Harding , Marisa Eisenberg

Automated mental health prediction using textual data has shown promising results with deep learning and large language models. However, deploying these models in high-stakes real-world settings remains challenging, as existing approaches…

Computation and Language · Computer Science 2026-05-07 Yucheng Ruan , Ling Huang , Qika Lin , Kai He , Mengling Feng

State-of-the-art approaches for the semantic labeling of LiDAR point clouds heavily rely on the use of deep Convolutional Neural Networks (CNNs). However, transferring network architectures across different LiDAR sensor types represents a…

Computer Vision and Pattern Recognition · Computer Science 2019-07-05 Florian Piewak , Peter Pinggera , Marius Zöllner

Interpretability of deep learning (DL) systems is gaining attention in medical imaging to increase experts' trust in the obtained predictions and facilitate their integration in clinical settings. We propose a deep visualization method to…

Computer Vision and Pattern Recognition · Computer Science 2022-02-02 Cristina González-Gonzalo , Bart Liefers , Bram van Ginneken , Clara I. Sánchez

There is a growing concern about typically opaque decision-making with high-performance machine learning algorithms. Providing an explanation of the reasoning process in domain-specific terms can be crucial for adoption in risk-sensitive…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Aditya Chattopadhyay , Stewart Slocum , Benjamin D. Haeffele , Rene Vidal , Donald Geman

In recent years, the field of medicine has been increasingly adopting artificial intelligence (AI) technologies to provide faster and more accurate disease detection, prediction, and assessment. In this study, we propose an interpretable AI…

Symbolic regression is emerging as a promising machine learning method for learning succinct underlying interpretable mathematical expressions directly from data. Whereas it has been traditionally tackled with genetic programming, it has…

Machine Learning · Computer Science 2025-01-14 Nour Makke , Sanjay Chawla

In some situations, the interpretability of the machine learning models plays a role as important as the model accuracy. Interpretability comes from the need to trust the prediction model, verify some of its properties, or even enforce them…

Machine Learning · Computer Science 2024-04-10 Guilherme Seidyo Imai Aldeia , Fabricio Olivetti de Franca
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