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Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

Surgery to treat elderly hip fracture patients may cause complications that can lead to early mortality. An early warning system for complications could provoke clinicians to monitor high-risk patients more carefully and address potential…

Machine Learning · Computer Science 2024-04-30 Jorn-Jan van de Beld , Shreyasi Pathak , Jeroen Geerdink , Johannes H. Hegeman , Christin Seifert

Multi-modal recommendation has gained traction as items possess rich attributes like text and images. Semantic ID-based approaches effectively discretize this information into compact tokens. However, two challenges persist: (1) Suboptimal…

Artificial Intelligence · Computer Science 2026-05-27 Pingjun Pan , Tingting Zhou , Peiyao Lu , Tingting Fei , Hongxiang Chen , Chuanjiang Luo

Oral cancer is frequently diagnosed at later stages due to its similarity to other lesions. Existing research on computer aided diagnosis has made progress using deep learning; however, most approaches remain limited by small, imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Joy Naoum , Revana Salama , Ali Hamdi

Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Aditya Shribhagwan Khandelwal , Mohammad Samar Ansari , Asra Aslam

Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival can improve our understanding of patient prognosis. However, this multimodal task is particularly challenging due to the different nature of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Guillaume Jaume , Anurag Vaidya , Richard Chen , Drew Williamson , Paul Liang , Faisal Mahmood

Multimodal survival methods combining gigapixel histology whole-slide images (WSIs) and transcriptomic profiles are particularly promising for patient prognostication and stratification. Current approaches involve tokenizing the WSIs into…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Andrew H. Song , Richard J. Chen , Guillaume Jaume , Anurag J. Vaidya , Alexander S. Baras , Faisal Mahmood

Multimodal learning combines information from multiple data modalities to improve predictive performance. However, modalities often contribute unequally and in a data dependent way, making it unclear which data modalities are genuinely…

Machine Learning · Statistics 2026-02-03 Mathew Chandy , Michael Johnson , Judong Shen , Devan V. Mehrotra , Hua Zhou , Jin Zhou , Xiaowu Dai

Unsupervised methods have proven effective for discriminative tasks in a single-modality scenario. In this paper, we present a multimodal framework for learning sparse representations that can capture semantic correlation between…

Machine Learning · Computer Science 2016-03-03 Miriam Cha , Youngjune Gwon , H. T. Kung

Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histology offers more comprehensive information. However, existing…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Yupei Zhang , Xiaofei Wang , Anran Liu , Lequan Yu , Chao Li

Predominately in explainable artificial intelligence (XAI) research, the Shapley value (SV) is applied to determine feature attributions for any black box model. Shapley interaction indices extend the SV to define any-order feature…

Machine Learning · Computer Science 2023-10-31 Fabian Fumagalli , Maximilian Muschalik , Patrick Kolpaczki , Eyke Hüllermeier , Barbara Hammer

Multi-modality image fusion aims at fusing modality-specific (complementarity) and modality-shared (correlation) information from multiple source images. To tackle the problem of the neglect of inter-feature relationships, high-frequency…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Xiaoli Zhang , Liying Wang , Libo Zhao , Xiongfei Li , Siwei Ma

Multimodal classification is a core task in human-centric machine learning. We observe that information is highly complementary across modalities, thus unimodal information can be drastically sparsified prior to multimodal fusion without…

Computer Vision and Pattern Recognition · Computer Science 2021-11-29 Yi Ding , Alex Rich , Mason Wang , Noah Stier , Matthew Turk , Pradeep Sen , Tobias Höllerer

This study introduces a novel multimodal food recognition framework that effectively combines visual and textual modalities to enhance classification accuracy and robustness. The proposed approach employs a dynamic multimodal fusion…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Prateek Mittal , Puneet Goyal , Joohi Chauhan

Spatial transcriptomics (ST) bridges gene expression and tissue morphology but faces clinical adoption barriers due to technical complexity and prohibitive costs. While computational methods predict gene expression from H&E-stained…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Ziqiao Weng , Yaoyu Fang , Jiahe Qian , Xinkun Wang , Lee AD Cooper , Weidong Cai , Bo Zhou

Whole slide images (WSIs) enable weakly supervised prognostic modeling via multiple instance learning (MIL). Spatial transcriptomics (ST) preserves in situ gene expression, providing a spatial molecular context that complements morphology.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Lihe Liu , Xiaoxi Pan , Yinyin Yuan , Lulu Shang

In recent years, the Shapley value and SHAP explanations have emerged as one of the most dominant paradigms for providing post-hoc explanations of black-box models. Despite their well-founded theoretical properties, many recent works have…

Machine Learning · Computer Science 2025-02-21 James Enouen , Yan Liu

This paper proposes a multimodal emotion recognition system based on hybrid fusion that classifies the emotions depicted by speech utterances and corresponding images into discrete classes. A new interpretability technique has been…

Computer Vision and Pattern Recognition · Computer Science 2023-01-10 Puneet Kumar , Sarthak Malik , Balasubramanian Raman

Explainable artificial intelligence (XAI) is essential for trustworthy machine learning (ML), particularly in high-stakes domains such as healthcare and finance. Shapley value (SV) methods provide a principled framework for feature…

Machine Learning · Statistics 2025-10-03 Wangxuan Fan , Siqi Li , Doudou Zhou , Yohei Okada , Chuan Hong , Molei Liu , Nan Liu

Whole slide imaging is fundamental to biomedical microscopy and computational pathology. Previously, learning representations for gigapixel-sized whole slide images (WSIs) has relied on multiple instance learning with weak labels, which do…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Xinhai Hou , Cheng Jiang , Akhil Kondepudi , Yiwei Lyu , Asadur Chowdury , Honglak Lee , Todd C. Hollon