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We propose Noise Conditional Variational Score Distillation (NCVSD), a novel method for distilling pretrained diffusion models into generative denoisers. We achieve this by revealing that the unconditional score function implicitly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Xinyu Peng , Ziyang Zheng , Yaoming Wang , Han Li , Nuowen Kan , Wenrui Dai , Chenglin Li , Junni Zou , Hongkai Xiong

Increasing use of CT in modern medical practice has raised concerns over associated radiation dose. Reduction of radiation dose associated with CT can increase noise and artifacts, which can adversely affect diagnostic confidence. Denoising…

Computer Vision and Pattern Recognition · Computer Science 2017-02-24 Qingsong Yang , Pingkun Yan , Mannudeep K. Kalra , Ge Wang

Image denoising is a fundamental operation in image processing and holds considerable practical importance for various real-world applications. Arguably several thousands of papers are dedicated to image denoising. In the past decade,…

Computer Vision and Pattern Recognition · Computer Science 2016-09-22 Wensen Feng , Peng Qiao , Xuanyang Xi , Yunjin Chen

Chemical imaging enables label-free visualization of cells, tissues and living systems while providing direct biochemical information that is difficult to obtain with conventional fluorescence microscopy. Despite its promise in applications…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yongkang Li , Brian Wong , King Wai Chiu , Hanwen Xu , Tangqi Fang , Erin Dunnington , Dan Fu , Sheng Wang

Acute respiratory distress syndrome (ARDS) is a severe condition characterized by lung inflammation and respiratory failure, with a high mortality rate of approximately 40%. Traditional imaging methods, such as chest X-rays, provide only…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Siyeop Yoon , Yujin Oh , Xiang Li , Yi Xin , Maurizio Cereda , Quanzheng Li

Positron Emission Tomography (PET) and Computed Tomography (CT) are essential for diagnosing, staging, and monitoring various diseases, particularly cancer. Despite their importance, the use of PET/CT systems is limited by the necessity for…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Dac Thai Nguyen , Trung Thanh Nguyen , Huu Tien Nguyen , Thanh Trung Nguyen , Huy Hieu Pham , Thanh Hung Nguyen , Thao Nguyen Truong , Phi Le Nguyen

Multispectral computed tomography (CT) enables advanced material characterization by acquiring energy-resolved projection data. However, since the incoming X-ray flux is be distributed across multiple narrow energy bins, the photon count…

Score-based diffusion models provide a powerful way to model images using the gradient of the data distribution. Leveraging the learned score function as a prior, here we introduce a way to sample data from a conditional distribution given…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Hyungjin Chung , Jong Chul Ye

Low-count positron emission tomography (LCPET) imaging can reduce patients' exposure to radiation but often suffers from increased image noise and reduced lesion detectability, necessitating effective denoising techniques. Diffusion models…

Image and Video Processing · Electrical Eng. & Systems 2025-03-24 Yinchi Zhou , Huidong Xie , Menghua Xia , Qiong Liu , Bo Zhou , Tianqi Chen , Jun Hou , Liang Guo , Xinyuan Zheng , Hanzhong Wang , Biao Li , Axel Rominger , Kuangyu Shi , Nicha C. Dvorneka , Chi Liu

PET is affected by statistical noise due to constraints on tracer dose and scan duration, impacting both diagnostic performance and quantitative accuracy. While deep learning (DL)-based PET denoising methods have been used to improve image…

Denoising diffusion models have recently shown impressive results in generative tasks. By learning powerful priors from huge collections of training images, such models are able to gradually modify complete noise to a clean natural image…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Naama Pearl , Yaron Brodsky , Dana Berman , Assaf Zomet , Alex Rav Acha , Daniel Cohen-Or , Dani Lischinski

Diffusion models, known for their powerful generative capabilities, play a crucial role in addressing real-world super-resolution challenges. However, these models often focus on improving local textures while neglecting the impacts of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Chunyang Bi , Xin Luo , Sheng Shen , Mengxi Zhang , Huanjing Yue , Jingyu Yang

Computational Super-Resolution (CSR) in fluorescence microscopy has, despite being an ill-posed problem, a long history. At its very core, CSR is about finding a prior that can be used to extrapolate frequencies in a micrograph that have…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Anirban Ray , Vera Galinova , Florian Jug

Diffusion probabilistic models (DPM) have been widely adopted in image-to-image translation to generate high-quality images. Prior attempts at applying the DPM to image super-resolution (SR) have shown that iteratively refining a pure…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Axi Niu , Kang Zhang , Trung X. Pham , Jinqiu Sun , Yu Zhu , In So Kweon , Yanning Zhang

Image denoising is a fundamental problem in computational photography, where achieving high perception with low distortion is highly demanding. Current methods either struggle with perceptual quality or suffer from significant distortion.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Tong Li , Hansen Feng , Lizhi Wang , Zhiwei Xiong , Hua Huang

Recent advances in denoising diffusion probabilistic models have shown great success in image synthesis tasks. While there are already works exploring the potential of this powerful tool in image semantic segmentation, its application in…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Xinrong Hu , Yu-Jen Chen , Tsung-Yi Ho , Yiyu Shi

The restoration of images affected by blur and noise has been widely studied and has broad potential for applications including in medical imaging modalities like computed tomography (CT). Although the blur and noise in CT images can be…

Medical Physics · Physics 2024-07-23 Yijie Yuan , Grace J. Gang , J. Webster Stayman

Purpose: Noise in diffusion-weighted MRI (dMRI) is often spatially correlated due to different acquisition and reconstruction strategies, which is not fully accounted for in current denoising strategies. Thus, we propose a novel model-based…

Signal Processing · Electrical Eng. & Systems 2025-12-22 Vinicius P. Campos , Diego Szczupak , Tales Santini , Afonso C. Silva , Alessandro Foi , Marcelo A. C. Vieira , Corey A. Baron

Rb-82 dynamic cardiac PET imaging is widely used for the clinical diagnosis of coronary artery disease (CAD), but its short half-life results in high noise levels that degrade dynamic frame quality and parametric imaging. The lack of paired…

Constrained Spherical Deconvolution (CSD) is widely used to estimate the white matter fiber orientation distribution (FOD) from diffusion MRI data. Its angular resolution depends on the maximum spherical harmonic order ($l_{max}$): low…