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We propose a fully unsupervised multi-modal deformable image registration method (UMDIR), which does not require any ground truth deformation fields or any aligned multi-modal image pairs during training. Multi-modal registration is a key…

Computer Vision and Pattern Recognition · Computer Science 2019-03-25 Chen Qin , Bibo Shi , Rui Liao , Tommaso Mansi , Daniel Rueckert , Ali Kamen

Visual Question Answering (VQA) becomes one of the most active research problems in the medical imaging domain. A well-known VQA challenge is the intrinsic diversity between the image and text modalities, and in the medical VQA task, there…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Yuan Zhou , Jing Mei , Yiqin Yu , Tanveer Syeda-Mahmood

In this paper, we propose \textbf{UniCode}, a novel approach within the domain of multimodal large language models (MLLMs) that learns a unified codebook to efficiently tokenize visual, text, and potentially other types of signals. This…

Computer Vision and Pattern Recognition · Computer Science 2024-03-15 Sipeng Zheng , Bohan Zhou , Yicheng Feng , Ye Wang , Zongqing Lu

The federated learning paradigm is wellsuited for the field of medical image analysis, as it can effectively cope with machine learning on isolated multicenter data while protecting the privacy of participating parties. However, current…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Zhekai Zhou , Guibo Luo , Mingzhi Chen , Zhenyu Weng , Yuesheng Zhu

We introduce UGen, a unified autoregressive multimodal model that demonstrates strong performance across text processing, image understanding, and image generation tasks simultaneously. UGen converts both texts and images into discrete…

Computation and Language · Computer Science 2025-03-28 Hongxuan Tang , Hao Liu , Xinyan Xiao

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from…

Machine Learning · Computer Science 2026-05-19 Xiaoguang Zhu , Linxiao Gong , Lianlong Sun , Yang Liu , Haoyu Wang , Jing Liu

While deep learning models have become the predominant method for medical image segmentation, they are typically not capable of generalizing to unseen segmentation tasks involving new anatomies, image modalities, or labels. Given a new…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Victor Ion Butoi , Jose Javier Gonzalez Ortiz , Tianyu Ma , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

Recent advancements in multimodal pre-training models have significantly advanced computational pathology. However, current approaches predominantly rely on visual-language models, which may impose limitations from a molecular perspective…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Minghao Han , Dingkang Yang , Jiabei Cheng , Xukun Zhang , Linhao Qu , Zizhi Chen , Lihua Zhang

Ultrasound is widely used in clinical practice due to its affordability, portability, and safety. However, current AI research often overlooks combined disease prediction and tissue segmentation. We propose UniUSNet, a universal framework…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Zehui Lin , Zhuoneng Zhang , Xindi Hu , Zhifan Gao , Xin Yang , Yue Sun , Dong Ni , Tao Tan

Multi-modal large language models (MLLMs) have shown impressive capabilities as a general-purpose interface for various visual and linguistic tasks. However, building a unified MLLM for multi-task learning in the medical field remains a…

Computer Vision and Pattern Recognition · Computer Science 2024-11-04 Xun Zhu , Ying Hu , Fanbin Mo , Miao Li , Ji Wu

Unified models (UMs) hold promise for their ability to understand and generate content across heterogeneous modalities. Compared to merely generating visual content, the use of UMs for interleaved cross-modal reasoning is more promising and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Jiachun Jin , Zetong Zhou , Xiao Yang , Hao Zhang , Pengfei Liu , Jun Zhu , Zhijie Deng

Autoregressive modeling has driven major advances in multimodal AI, yet its application to medical imaging remains constrained by the absence of a unified image tokenizer that simultaneously preserves fine-grained anatomical structures and…

Image and Video Processing · Electrical Eng. & Systems 2026-04-02 Chenglong Ma , Yuanfeng Ji , Jin Ye , Zilong Li , Chenhui Wang , Junzhi Ning , Wei Li , Lihao Liu , Qiushan Guo , Tianbin Li , Junjun He , Hongming Shan

Segmentation maps of medical images annotated by medical experts contain rich spatial information. In this paper, we propose to decompose annotation maps to learn disentangled and richer feature transforms for segmentation problems in…

Image and Video Processing · Electrical Eng. & Systems 2019-06-10 Yizhe Zhang , Michael T. C. Ying , Danny Z. Chen

Multi-modal medical images provide complementary soft-tissue characteristics that aid in the screening and diagnosis of diseases. However, limited scanning time, image corruption and various imaging protocols often result in incomplete…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Yue Zhang , Chengtao Peng , Qiuli Wang , Dan Song , Kaiyan Li , S. Kevin Zhou

Learning-based medical image registration has matched the accuracy of conventional methods while offering superior computational efficiency. However, existing approaches suffer from poor generalization across diverse clinical scenarios,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Zi Li , Jianpeng Zhang , Tai Ma , Tony C. W. Mok , Yan-Jie Zhou , Zeli Chen , Xianghua Ye , Le Lu , Cheng Chen , Dakai Jin

Multimodal human action understanding is a significant problem in computer vision, with the central challenge being the effective utilization of the complementarity among diverse modalities while maintaining model efficiency. However, most…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Hongsong Wang , Heng Fei , Bingxuan Dai , Jie Gui

In clinical practice, medical segmentation datasets are often limited and heterogeneous, with variations in modalities, protocols, and anatomical targets across institutions. Existing deep learning models struggle to jointly learn from such…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Weiwei Ma , Xiaobing Yu , Peijie Qiu , Jin Yang , Pan Xiao , Xiaoqi Zhao , Xiaofeng Liu , Tomo Miyazaki , Shinichiro Omachi , Yongsong Huang

Molecular representation learning is fundamental for many drug related applications. Most existing molecular pre-training models are limited in using single molecular modality, either SMILES or graph representation. To effectively leverage…

Machine Learning · Computer Science 2024-11-05 Shikun Feng , Lixin Yang , Yanwen Huang , Yuyan Ni , Weiying Ma , Yanyan Lan

Recent advancements in language models have significantly enhanced performance in multiple speech-related tasks. Existing speech language models typically utilize task-dependent prompt tokens to unify various speech tasks in a single model.…

Computation and Language · Computer Science 2024-02-01 Yihan Wu , Soumi Maiti , Yifan Peng , Wangyou Zhang , Chenda Li , Yuyue Wang , Xihua Wang , Shinji Watanabe , Ruihua Song

3D image segmentation plays an important role in biomedical image analysis. Many 2D and 3D deep learning models have achieved state-of-the-art segmentation performance on 3D biomedical image datasets. Yet, 2D and 3D models have their own…

Computer Vision and Pattern Recognition · Computer Science 2018-12-11 Hao Zheng , Yizhe Zhang , Lin Yang , Peixian Liang , Zhuo Zhao , Chaoli Wang , Danny Z. Chen