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We developed a software pipeline for quality control (QC) of histopathology whole slide images (WSIs) that segments various regions, such as blurs of different levels, tissue regions, tissue folds, and pen marks. Given the necessity and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Abhijeet Patil , Garima Jain , Harsh Diwakar , Jay Sawant , Tripti Bameta , Swapnil Rane , Amit Sethi

In modern cancer diagnostics, Whole Slide Imaging (WSI) is widely used to digitize tissue specimens for detailed, high-resolution examination; however, other diagnostic approaches, such as liquid biopsy and molecular testing, are also…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Seyed Kahaki , Alexander R. Webber , Ghada Zamzmi , Adarsh Subbaswamy , Rucha Deshpande , Aldo Badano

Whole-slide image analysis is essential for diagnostic tasks in pathology, yet existing deep learning methods primarily rely on flat classification, ignoring hierarchical relationships among class labels. In this study, we propose HiClass,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Keunho Byeon , Jinsol Song , Seong Min Hong , Yosep Chong , Jin Tae Kwak

Histopathological images provide rich information for disease diagnosis. Large numbers of histopathological images have been digitized into high resolution whole slide images, opening opportunities in developing computational image analysis…

Image and Video Processing · Electrical Eng. & Systems 2020-11-06 Jiayun Li , Wenyuan Li , Anthony Sisk , Huihui Ye , W. Dean Wallace , William Speier , Corey W. Arnold

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Recent advancements in Digital Pathology (DP), particularly through artificial intelligence and Foundation Models, have underscored the importance of large-scale, diverse, and richly annotated datasets. Despite their critical role, publicly…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Dmitry Nechaev , Alexey Pchelnikov , Ekaterina Ivanova

High-throughput "pathomic" analysis of Whole Slide Images (WSIs) offers new opportunities to study tissue characteristics and for biomarker discovery. However, the clinical relevance of the tissue characteristics at the micro- and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 Yuechen Yang , Junlin Guo , Yanfan Zhu , Jialin Yue , Junchao Zhu , Yu Wang , Shilin Zhao , Haichun Yang , Xingyi Guo , Jovan Tanevski , Laura Barisoni , Avi Z. Rosenberg , Yuankai Huo

In pathological research, education, and clinical practice, the decision-making process based on pathological images is critically important. This significance extends to digital pathology image analysis: its adequacy is demonstrated by the…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Zhi-Bo Liu , Xiaobo Pang , Jizhao Wang , Shuai Liu , Chen Li

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Jiawen Li , Qiehe Sun , Renao Yan , Yizhi Wang , Yuqiu Fu , Yani Wei , Tian Guan , Huijuan Shi , Yonghonghe He , Anjia Han

Digital whole slide images (WSIs) are generally captured at microscopic resolution and encompass extensive spatial data. Directly feeding these images to deep learning models is computationally intractable due to memory constraints, while…

Image and Video Processing · Electrical Eng. & Systems 2024-11-22 Manahil Raza , Ruqayya Awan , Raja Muhammad Saad Bashir , Talha Qaiser , Nasir M. Rajpoot

Recent advances in whole-slide image (WSI) scanners and computational capabilities have significantly propelled the application of artificial intelligence in histopathology slide analysis. While these strides are promising, current…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Weiyi Wu , Chongyang Gao , Joseph DiPalma , Soroush Vosoughi , Saeed Hassanpour

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Representation learning for Whole Slide Images (WSIs) is pivotal in developing image-based systems to achieve higher precision in diagnostic pathology. We propose a two-stage framework for WSI representation learning. We sample relevant…

Image and Video Processing · Electrical Eng. & Systems 2020-04-20 Mohammed Adnan , Shivam Kalra , Hamid R. Tizhoosh

Computational pathology methods have the potential to improve access to precision medicine, as well as the reproducibility and accuracy of pathological diagnoses. Particularly the analysis of whole-slide-images (WSIs) of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Philippe Weitz , Viktoria Sartor , Balazs Acs , Stephanie Robertson , Daniel Budelmann , Johan Hartman , Mattias Rantalainen

Histopathology tissue analysis is considered the gold standard in cancer diagnosis and prognosis. Given the large size of these images and the increase in the number of potential cancer cases, an automated solution as an aid to…

Image and Video Processing · Electrical Eng. & Systems 2020-11-19 Mahendra Khened , Avinash Kori , Haran Rajkumar , Balaji Srinivasan , Ganapathy Krishnamurthi

A Whole Slide Image (WSI) is a high-resolution digital image created by scanning an entire glass slide containing a biological specimen, such as tissue sections or cell samples, at multiple magnifications. These images are digitally…

Advances in optical microscopy scanning have significantly contributed to computational pathology (CPath) by converting traditional histopathological slides into whole slide images (WSIs). This development enables comprehensive digital…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Xitong Ling , Yuanyuan Lei , Jiawen Li , Junru Cheng , Wenting Huang , Tian Guan , Jian Guan , Yonghong He
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