English
Related papers

Related papers: Controlled LLM-based Reasoning for Clinical Trial …

200 papers

This paper investigates whether recent advances in Large Language Models (LLMs) can assist in translating human explanations into a format that can robustly support learning Linear Temporal Logic (LTL) from demonstrations. Both LLMs and…

Artificial Intelligence · Computer Science 2024-04-04 Ashutosh Gupta , John Komp , Abhay Singh Rajput , Krishna Shankaranarayanan , Ashutosh Trivedi , Namrita Varshney

This paper describes the submissions of the Natural Language Processing (NLP) team from the Australian Research Council Industrial Transformation Training Centre (ITTC) for Cognitive Computing in Medical Technologies to the TREC 2021…

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Health care professionals rely on treatment search engines to efficiently find adequate clinical trials and early access programs for their patients. However, doctors lose trust in the system if its underlying processes are unclear and…

Information Retrieval · Computer Science 2021-10-26 Edeline Contempré , Zoltán Szlávik , Majid Mohammadi , Erick Velazquez , Annette ten Teije , Ilaria Tiddi

Europe's healthcare systems require enhanced interoperability and digitalization, driving a demand for innovative solutions to process legacy clinical data. This paper presents the results of our project, which aims to leverage Large…

Computation and Language · Computer Science 2025-07-09 Aynur Guluzade , Naguib Heiba , Zeyd Boukhers , Florim Hamiti , Jahid Hasan Polash , Yehya Mohamad , Carlos A Velasco

Clinical reasoning refers to the cognitive process that physicians employ in evaluating and managing patients. This process typically involves suggesting necessary examinations, diagnosing patients' diseases, and deciding on appropriate…

Computation and Language · Computer Science 2024-06-11 Jiageng WU , Xian Wu , Jie Yang

Clinical language processing has received a lot of attention in recent years, resulting in new models or methods for disease phenotyping, mortality prediction, and other tasks. Unfortunately, many of these approaches are tested under…

Computation and Language · Computer Science 2022-09-30 Travis R. Goodwin , Dina Demner-Fushman

Interpretation is critical for disease diagnosis, but existing models struggle to balance predictive accuracy with human-understandable rationales. While large language models (LLMs) offer strong reasoning abilities, their clinical use is…

Computation and Language · Computer Science 2025-07-15 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Yida Xu , Yunya Song , Xian Yang

Clinical trials are a critical process in the medical field for introducing new treatments and innovations. However, cohort selection for clinical trials is a time-consuming process that often requires manual review of patient text records…

Computation and Language · Computer Science 2025-01-22 Chi-en Amy Tai , Xavier Tannier

Clinical trials are critical for drug development. Constructing the appropriate eligibility criteria (i.e., the inclusion/exclusion criteria for patient recruitment) is essential for the trial's success. Proper design of clinical trial…

Computation and Language · Computer Science 2023-10-10 Zifeng Wang , Cao Xiao , Jimeng Sun

Extracting structured medical insights from unstructured clinical text using Natural Language Processing (NLP) remains an open challenge in healthcare, particularly in non-English contexts where resources are scarce. This study presents a…

Artificial Intelligence · Computer Science 2025-11-21 Paulina Tworek , Miłosz Bargieł , Yousef Khan , Tomasz Pełech-Pilichowski , Marek Mikołajczyk , Roman Lewandowski , Jose Sousa

Large language models (LLMs) are increasingly used in statistical research and applications. However,they are also notorious for unreliable or biased information. Here, we explore whether LLMs can be used to improve the precision of…

Applications · Statistics 2026-05-29 Jaylin Lowe , Adam Sales , Johann A. Gagnon-Bartsch

Recommender systems are tasked to infer users' evolving preferences and rank items aligned with their intents, which calls for in-depth reasoning beyond pattern-based scoring. Recent efforts start to leverage large language models (LLMs)…

Information Retrieval · Computer Science 2026-02-16 Kehan Zheng , Deyao Hong , Qian Li , Jun Zhang , Huan Yu , Jie Jiang , Hongning Wang

Large Language Models (LLMs) often exhibit limited logical coherence, mapping premises to conclusions without adherence to explicit inference rules. We propose Proof-Carrying Reasoning with LLMs (PCRLLM), a framework that constrains…

Computation and Language · Computer Science 2025-11-12 Tangrui Li , Pei Wang , Hongzheng Wang Christian Hahm , Matteo Spatola , Justin Shi

Large Language Models (LLMs) have achieved high accuracy on medical question-answer (QA) benchmarks, yet their capacity for flexible clinical reasoning has been debated. Here, we asked whether advances in reasoning LLMs improve their…

Computation and Language · Computer Science 2026-01-21 Kie Shidara , Preethi Prem , Jonathan Kim , Anna Podlasek , Feng Liu , Ahmed Alaa , Danilo Bernardo

Large Language Models (LLMs) are increasingly used to evaluate information retrieval (IR) systems, generating relevance judgments traditionally made by human assessors. Recent empirical studies suggest that LLM-based evaluations often align…

Information Retrieval · Computer Science 2026-01-21 Laura Dietz , Oleg Zendel , Peter Bailey , Charles Clarke , Ellese Cotterill , Jeff Dalton , Faegheh Hasibi , Mark Sanderson , Nick Craswell

It is becoming increasingly emphasis on the importance of LLM participating in clinical diagnosis decision-making. However, the low specialization refers to that current medical LLMs can not provide specific medical advice, which are more…

Computation and Language · Computer Science 2023-12-06 Binbin Li , Tianxin Meng , Xiaoming Shi , Jie Zhai , Tong Ruan

Legal services rely heavily on text processing. While large language models (LLMs) show promise, their application in legal contexts demands higher accuracy, repeatability, and transparency. Logic programs, by encoding legal concepts as…

Computers and Society · Computer Science 2025-02-26 Manuj Kant , Sareh Nabi , Manav Kant , Roland Scharrer , Megan Ma , Marzieh Nabi

Despite the dramatic progress in Large Language Model (LLM) development, LLMs often provide seemingly plausible but not factual information, often referred to as hallucinations. Retrieval-augmented LLMs provide a non-parametric approach to…

Computation and Language · Computer Science 2023-11-09 Sai Munikoti , Anurag Acharya , Sridevi Wagle , Sameera Horawalavithana

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang