English
Related papers

Related papers: Controlled LLM-based Reasoning for Clinical Trial …

200 papers

Reasoning Large Language Models (LLMs) with enhanced accuracy and explainability are increasingly being adopted in the medical domain, as the life-critical nature of clinical decision-making demands reliable support. Despite these…

Computation and Language · Computer Science 2025-11-12 Sung-Min Lee , Siyoon Lee , Juyeon Kim , Kyoungmin Roh

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

Objective. Clinical AI documentation systems require evaluation methodologies that are clinically valid, economically viable, and sensitive to iterative changes. Methods requiring expert review per scoring instance are too slow and…

Artificial Intelligence · Computer Science 2026-04-28 Aaryan Shah , Andrew Hines , Alexia Downs , Denis Bajet , Paulius Mui , Fabiano Araujo , Laura Offutt , Aida Rutledge , Elizabeth Jimenez

Background: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews. Prior research using text-only models have struggled to address this problem in a reliable and scalable way…

Computation and Language · Computer Science 2025-03-20 Anatole Callies , Quentin Bodinier , Philippe Ravaud , Kourosh Davarpanah

Recent advances in large language models (LLMs) have enabled near-human performance on software coding benchmarks, but their effectiveness in RTL code generation remains limited due to the scarcity of high-quality training data. While prior…

Hardware Architecture · Computer Science 2025-07-17 Chenhui Deng , Yun-Da Tsai , Guan-Ting Liu , Zhongzhi Yu , Haoxing Ren

Large language models (LLMs) are increasingly deployed across healthcare applications, including clinical documentation, diagnostic reasoning, medicine recommendation, and medical education. Their outputs are largely unstructured clinical…

Computers and Society · Computer Science 2026-05-26 Lingyao Li , Deyi Li , Chen Chen , Renkai Ma , Runlong Yu , Mingquan Lin , Rui Yin , Lizhou Fan , Cathy Shyr , Siyuan Ma , Mei Liu , Steven Bethard

The reasoning capabilities of large language models (LLMs) have significantly advanced their performance by enabling in-depth understanding of diverse tasks. With growing interest in applying LLMs to the time series domain, this has proven…

Artificial Intelligence · Computer Science 2025-06-03 Jiahui Zhou , Dan Li , Lin Li , Zhuomin Chen , Shunyu Wu , Haozheng Ye , Jian Lou , Costas J. Spanos

Recent claims of strong performance by Large Language Models (LLMs) on causal discovery are undermined by a key flaw: many evaluations rely on benchmarks likely included in pretraining corpora. Thus, apparent success suggests that LLM-only…

In search settings, calibrating the scores during the ranking process to quantities such as click-through rates or relevance levels enhances a system's usefulness and trustworthiness for downstream users. While previous research has…

Information Retrieval · Computer Science 2024-08-28 Puxuan Yu , Daniel Cohen , Hemank Lamba , Joel Tetreault , Alex Jaimes

Statutory law retrieval is a typical problem in legal language processing, that has various practical applications in law engineering. Modern deep learning-based retrieval methods have achieved significant results for this problem. However,…

Computation and Language · Computer Science 2024-10-17 Hai-Long Nguyen , Tan-Minh Nguyen , Duc-Minh Nguyen , Thi-Hai-Yen Vuong , Ha-Thanh Nguyen , Xuan-Hieu Phan

Having a unified, coherent taxonomy is essential for effective knowledge representation in domain-specific applications as diverse terminologies need to be mapped to underlying concepts. Traditional manual approaches to taxonomy alignment…

Large language models (LLMs) are increasingly used as raters for evaluation tasks. However, their reliability is often limited for subjective tasks, when human judgments involve subtle reasoning beyond annotation labels. Thinking traces,…

Artificial Intelligence · Computer Science 2026-02-23 Xingjian Zhang , Tianhong Gao , Suliang Jin , Tianhao Wang , Teng Ye , Eytan Adar , Qiaozhu Mei

Advances in large language models (LLMs) have encouraged their adoption in the healthcare domain where vital clinical information is often contained in unstructured notes. Cancer staging status is available in clinical reports, but it…

Computation and Language · Computer Science 2024-08-30 Chia-Hsuan Chang , Mary M. Lucas , Yeawon Lee , Christopher C. Yang , Grace Lu-Yao

Patient recruitment remains a major bottleneck in clinical trials, calling for scalable and automated solutions. We present TrialMatchAI, an AI-powered recommendation system that automates patient-to-trial matching by processing…

With generative artificial intelligence (AI), particularly large language models (LLMs), continuing to make inroads in healthcare, it is critical to supplement traditional automated evaluations with human evaluations. Understanding and…

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

Large language models (LLMs) have demonstrated impressive performance across various domains. However, for clinical diagnosis, higher expectations are required for LLM's reliability and sensitivity: thinking like physicians and remaining…

Computation and Language · Computer Science 2025-04-21 Chenwei Yan , Xiangling Fu , Yuxuan Xiong , Tianyi Wang , Siu Cheung Hui , Ji Wu , Xien Liu

As Large Language Models (LLMs) become integrated into high-stakes domains, there is a growing need for evaluation methods that are both scalable for real-time deployment and reliable for critical decision-making. While human evaluation is…

Artificial Intelligence · Computer Science 2025-12-02 Xiaochuan Li , Ke Wang , Girija Gouda , Shubham Choudhary , Yaqun Wang , Linwei Hu , Joel Vaughan , Freddy Lecue

The integration of Large Language Models (LLMs) into biomedical research offers new opportunities for domainspecific reasoning and knowledge representation. However, their performance depends heavily on the semantic quality of training…

Large language models (LLMs) are increasingly used to extract clinical data from electronic health records (EHRs), offering significant improvements in scalability and efficiency for real-world data (RWD) curation in oncology. However, the…