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Retrieval-Augmented Generation (RAG) has emerged as a powerful approach for enhancing large language models' question-answering capabilities through the integration of external knowledge. However, when adapting RAG systems to specialized…

Computation and Language · Computer Science 2026-01-19 Xin Sun , Zhongqi Chen , Qiang Liu , Shu Wu , Bowen Song , Weiqiang Wang , Zilei Wang , Liang Wang

Increasing clinical trial protocol complexity, amendments, and challenges around knowledge management create significant burden for trial teams. Structuring protocol content into standard formats has the potential to improve efficiency,…

Information Retrieval · Computer Science 2026-04-20 Ramtin Babaeipour , François Charest , Madison Wright

Large language models (LLMs) are very costly and inefficient to update with new information. To address this limitation, retrieval-augmented generation (RAG) has been proposed as a solution that dynamically incorporates external knowledge…

Computation and Language · Computer Science 2025-07-10 Sezen Perçin , Xin Su , Qutub Sha Syed , Phillip Howard , Aleksei Kuvshinov , Leo Schwinn , Kay-Ulrich Scholl

Large language models (LLMs) have achieved strong empirical performance in various fields, benefiting from their huge amount of parameters that store knowledge. However, LLMs still suffer from several key issues, such as hallucination…

Computation and Language · Computer Science 2026-05-20 Shangyu Wu , Ying Xiong , Yufei Cui , Haolun Wu , Can Chen , Ye Yuan , Lianming Huang , Xue Liu , Tei-Wei Kuo , Nan Guan , Chun Jason Xue

Iterative retrieval refers to the process in which the model continuously queries the retriever during generation to enhance the relevance of the retrieved knowledge, thereby improving the performance of Retrieval-Augmented Generation…

Computation and Language · Computer Science 2024-12-02 Tian Yu , Shaolei Zhang , Yang Feng

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Artificial Intelligence (AI) has demonstrated significant potential in healthcare, particularly in disease diagnosis and treatment planning. Recent progress in Medical Large Vision-Language Models (Med-LVLMs) has opened up new possibilities…

Machine Learning · Computer Science 2025-03-04 Peng Xia , Kangyu Zhu , Haoran Li , Tianze Wang , Weijia Shi , Sheng Wang , Linjun Zhang , James Zou , Huaxiu Yao

Background The increasing adoption of Artificial Intelligence (AI) in healthcare has sparked growing concerns about its environmental and ethical implications. Commercial Large Language Models (LLMs), such as ChatGPT and DeepSeek, require…

Artificial Intelligence · Computer Science 2025-06-26 Konstantinos Vrettos , Michail E. Klontzas

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Retrieval-Augmented Generation (RAG) has emerged as a powerful framework to improve factuality in large language models (LLMs) by grounding their outputs in retrieved documents. However, ensuring perfect retrieval of relevant information…

Computation and Language · Computer Science 2025-12-04 Zhan Peng Lee , Andre Lin , Calvin Tan

Retrieval-Augmented Generation (RAG) systems have recently shown remarkable advancements by integrating retrieval mechanisms into language models, enhancing their ability to produce more accurate and contextually relevant responses.…

Computation and Language · Computer Science 2025-01-14 Siran Li , Linus Stenzel , Carsten Eickhoff , Seyed Ali Bahrainian

Retrieval-Augmented Generation (RAG) has emerged as a standard framework for knowledge-intensive NLP tasks, combining large language models (LLMs) with document retrieval from external corpora. Despite its widespread use, most RAG pipelines…

Information Retrieval · Computer Science 2025-08-26 Mandeep Rathee , V Venktesh , Sean MacAvaney , Avishek Anand

Retriever-augmented generation (RAG) has become a widely adopted approach for enhancing the factual accuracy of large language models (LLMs). While current benchmarks evaluate the performance of RAG methods from various perspectives, they…

Information Retrieval · Computer Science 2025-04-08 Kepu Zhang , Zhongxiang Sun , Weijie Yu , Xiaoxue Zang , Kai Zheng , Yang Song , Han Li , Jun Xu

Retrieval-Augmented Generation (RAG) grounds large language models with external evidence, but many implementations rely on pre-built indices that remain static after construction. Related queries therefore repeat similar multi-hop…

Artificial Intelligence · Computer Science 2026-03-03 Yifan Wang , Mingxuan Jiang , Zhihao Sun , Yixin Cao , Yicun Liu , Keyang Chen , Guangnan Ye , Hongfeng Chai

Retrieval Augmented Generation (RAG) is a common method for integrating external knowledge into pretrained Large Language Models (LLMs) to enhance accuracy and relevancy in question answering (QA) tasks. However, prompt engineering and…

Computation and Language · Computer Science 2024-10-18 Isaac Chung , Phat Vo , Arman C. Kizilkale , Aaron Reite

Retrieval-Augmented Generation (RAG) has become critical for knowledge-intensive applications, yet evaluating its performance in vertical domains remains difficult due to domain complexity, diverse context scales, and heavy reliance on…

Computation and Language · Computer Science 2026-05-27 Jingbin Qian , Congwen Yi , Min Xia , Wen Wu , Jun Zhu , Jian Guan

Retrieval-augmented generation (RAG) has shown promising potential in knowledge intensive question answering (QA). However, existing approaches only consider the query itself, neither specifying the retrieval preferences for the retrievers…

Information Retrieval · Computer Science 2025-02-18 Zhongwu Chen , Chengjin Xu , Dingmin Wang , Zhen Huang , Yong Dou , Xuhui Jiang , Jian Guo

Large language models (LLMs) typically utilize the top-k contexts from a retriever in retrieval-augmented generation (RAG). In this work, we propose a novel instruction fine-tuning framework RankRAG, which instruction-tunes a single LLM for…

Computation and Language · Computer Science 2024-07-03 Yue Yu , Wei Ping , Zihan Liu , Boxin Wang , Jiaxuan You , Chao Zhang , Mohammad Shoeybi , Bryan Catanzaro

Advancements in model algorithms, the growth of foundational models, and access to high-quality datasets have propelled the evolution of Artificial Intelligence Generated Content (AIGC). Despite its notable successes, AIGC still faces…

Computer Vision and Pattern Recognition · Computer Science 2024-06-24 Penghao Zhao , Hailin Zhang , Qinhan Yu , Zhengren Wang , Yunteng Geng , Fangcheng Fu , Ling Yang , Wentao Zhang , Jie Jiang , Bin Cui

Retrieval-Augmented Generation RAG systems enhance large language models by grounding responses in external knowledge bases, but conventional RAG architectures operate with static corpora that cannot evolve from user interactions. We…

Artificial Intelligence · Computer Science 2025-12-30 Teja Chinthala