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Tree-based phylogenetic networks, which may be roughly defined as leaf-labeled networks built by adding arcs only between the original tree edges, have elegant properties for modeling evolutionary histories. We answer an open question of…

Computing an optimal classification tree that provably maximizes training performance within a given size limit, is NP-hard, and in practice, most state-of-the-art methods do not scale beyond computing optimal trees of depth three.…

Machine Learning · Computer Science 2025-01-15 Catalin E. Brita , Jacobus G. M. van der Linden , Emir Demirović

Tree search algorithms, such as branch-and-bound, are the most widely used tools for solving combinatorial and nonconvex problems. For example, they are the foremost method for solving (mixed) integer programs and constraint satisfaction…

Artificial Intelligence · Computer Science 2018-05-18 Maria-Florina Balcan , Travis Dick , Tuomas Sandholm , Ellen Vitercik

We propose the first branch-&-price algorithm for the maximum agreement forest problem on unrooted binary trees: given two unrooted X-labelled binary trees we seek to partition X into a minimum number of blocks such that the induced…

Data Structures and Algorithms · Computer Science 2024-10-08 Martin Frohn , Steven Kelk , Simona Vychytilova

Maximum parsimony distance is a measure used to quantify the dissimilarity of two unrooted phylogenetic trees. It is NP-hard to compute, and very few positive algorithmic results are known due to its complex combinatorial structure. Here we…

Data Structures and Algorithms · Computer Science 2020-04-07 Mark Jones , Steven Kelk , Leen Stougie

Phylogenetic networks are a flexible model of evolution that can represent reticulate evolution and handle complex data. Tree-based networks, which are phylogenetic networks that have a spanning tree with the same root and leaf-set as the…

Combinatorics · Mathematics 2023-05-25 Takatora Suzuki , Han Guo , Momoko Hayamizu

The supertree construction problem is about combining several phylogenetic trees with possibly conflicting information into a single tree that has all the leaves of the source trees as its leaves and the relationships between the leaves are…

Computational Engineering, Finance, and Science · Computer Science 2020-02-19 Laura Koponen , Emilia Oikarinen , Tomi Janhunen , Laura Säilä

An ordered labeled tree is a tree in which the nodes are labeled and the left-to-right order among siblings is relevant. The edit distance between two ordered labeled trees is the minimum cost of changing one tree into the other through a…

Data Structures and Algorithms · Computer Science 2015-02-10 Shihyen Chen

In this paper we investigate an extremal problem on binary phylogenetic trees. Given two such trees $T_1$ and $T_2$, both with leaf-set ${1,2,...,n}$, we are interested in the size of the largest subset $S \subseteq {1,2,...,n}$ of leaves…

Combinatorics · Mathematics 2013-02-21 Daniel M. Martin , Bhalchandra D. Thatte

Many popular algorithms for searching the space of leaf-labelled trees are based on tree rearrangement operations. Under any such operation, the problem is reduced to searching a graph where vertices are trees and (undirected) edges are…

Data Structures and Algorithms · Computer Science 2020-07-27 Lena Collienne , Alex Gavryushkin

Model trees provide an appealing way to perform interpretable machine learning for both classification and regression problems. In contrast to ``classic'' decision trees with constant values in their leaves, model trees can use linear…

Machine Learning · Computer Science 2026-03-11 Sabino Francesco Roselli , Eibe Frank

Genomes and genes diversify during evolution; however, it is unclear to what extent genes still retain the relationship among species. Model species for molecular phylogenetic studies include yeasts and viruses whose genomes were sequenced…

Genomics · Quantitative Biology 2008-06-09 Yunfeng Shan , Xiu-Qing Li

We consider a variant of treewidth that we call clique-partitioned treewidth in which each bag is partitioned into cliques. This is motivated by the recent development of FPT-algorithms based on similar parameters for various problems. With…

Data Structures and Algorithms · Computer Science 2023-02-20 Thomas Bläsius , Maximilian Katzmann , Marcus Wilhelm

We give a 2-approximation algorithm for the Maximum Agreement Forest problem on two rooted binary trees. This NP-hard problem has been studied extensively in the past two decades, since it can be used to compute the rooted Subtree…

Data Structures and Algorithms · Computer Science 2018-11-15 Neil Olver , Frans Schalekamp , Suzanne van der Ster , Leen Stougie , Anke van Zuylen

Given a digraph $D$, the Minimum Leaf Out-Branching problem (MinLOB) is the problem of finding in $D$ an out-branching with the minimum possible number of leaves, i.e., vertices of out-degree 0. We prove that MinLOB is polynomial-time…

Data Structures and Algorithms · Computer Science 2008-10-14 G. Gutin , I. Razgon , E. J. Kim

When performing an analysis on a collection of molecular sequences, it can be convenient to reduce the number of sequences under consideration while maintaining some characteristic of a larger collection of sequences. For example, one may…

Populations and Evolution · Quantitative Biology 2012-09-03 Frederick A. Matsen , Aaron Gallagher , Connor McCoy

In this article we study the treewidth of the \emph{display graph}, an auxiliary graph structure obtained from the fusion of phylogenetic (i.e., evolutionary) trees at their leaves. Earlier work has shown that the treewidth of the display…

Discrete Mathematics · Computer Science 2017-04-03 Steven Kelk , Georgios Stamoulis , Taoyang Wu

The algebraic properties of flattenings and subflattenings provide direct methods for identifying edges in the true phylogeny -- and by extension the complete tree -- using pattern counts from a sequence alignment. The relatively small…

Populations and Evolution · Quantitative Biology 2022-05-06 Joshua Stevenson , Barbara Holland , Michael Charleston , Jeremy Sumner

Given a set of leaf-labeled trees with identical leaf sets, the well-known "Maximum Agreement SubTree" problem (MAST) consists of finding a subtree homeomorphically included in all input trees and with the largest number of leaves. Its…

Computational Complexity · Computer Science 2008-07-10 Sylvain Guillemot , Francois Nicolas

Recently, a new vector encoding, Ordered Leaf Attachment (OLA), was introduced that represents $n$-leaf phylogenetic trees as $n-1$ length integer vectors by recording the placement location of each leaf. Both encoding and decoding of trees…

Populations and Evolution · Quantitative Biology 2025-09-23 Alexey Markin , Tavis K. Anderson