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Uncertainty quantification plays a vital role in facilitating the practical implementation of AI in radiology by addressing growing concerns around trustworthiness. Given the challenges associated with acquiring large, annotated datasets in…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Bala McRae-Posani , Andrei Holodny , Hrithwik Shalu , Joseph N Stember

Deep learning has played a major role in the interpretation of dermoscopic images for detecting skin defects and abnormalities. However, current deep learning solutions for dermatological lesion analysis are typically limited in providing…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Gun-Hee Lee , Han-Bin Ko , Seong-Whan Lee

We evaluate two different methods for the integration of prediction uncertainty into diagnostic image classifiers to increase patient safety in deep learning. In the first method, Monte Carlo sampling is applied with dropout at test time to…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

Accurate estimation of uncertainty in deep learning is critical for deploying models in high-stakes domains such as medical diagnosis and autonomous decision-making, where overconfident predictions can lead to harmful outcomes. In practice,…

Machine Learning · Computer Science 2026-03-12 Xinran Xu , Xiuyi Fan

Reliable tumor segmentation in thoracic computed tomography (CT) remains challenging due to boundary ambiguity, class imbalance, and anatomical variability. We propose an uncertainty-guided, coarse-to-fine segmentation framework that…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Ilkin Sevgi Isler , David Mohaisen , Curtis Lisle , Damla Turgut , Ulas Bagci

Deep learning techniques have significantly advanced in providing accurate visual odometry solutions by leveraging large datasets. However, generating uncertainty estimates for these methods remains a challenge. Traditional sensor fusion…

Robotics · Computer Science 2024-03-21 Jagatpreet Singh Nir , Dennis Giaya , Hanumant Singh

Differential equations in general and neural ODEs in particular are an essential technique in continuous-time system identification. While many deterministic learning algorithms have been designed based on numerical integration via the…

Machine Learning · Computer Science 2021-10-18 Lenart Treven , Philippe Wenk , Florian Dörfler , Andreas Krause

Detecting out-of-distribution (OOD) data is a fundamental challenge in the deployment of machine learning models. From a security standpoint, this is particularly important because OOD test data can result in misleadingly confident yet…

Machine Learning · Computer Science 2025-02-25 Onat Gungor , Amanda Sofie Rios , Nilesh Ahuja , Tajana Rosing

Automated organ at risk (OAR) segmentation is crucial for radiation therapy planning in CT scans, but the generated contours by automated models can be inaccurate, potentially leading to treatment planning issues. The reasons for these…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Amin Honarmandi Shandiz , Attila Rádics , Rajesh Tamada , Makk Árpád , Karolina Glowacka , Lehel Ferenczi , Sandeep Dutta , Michael Fanariotis

The delineation of tumor target and organs-at-risk is critical in the radiotherapy treatment planning. Automatic segmentation can be used to reduce the physician workload and improve the consistency. However, the quality assurance of the…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Yihao Zhao , Cuiyun Yuan , Ying Liang , Yang Li , Chunxia Li , Man Zhao , Jun Hu , Wei Liu , Chenbin Liu

Purpose: Optical imaging is evolving as a key technique for advanced sensing in the operating room. Recent research has shown that machine learning algorithms can be used to address the inverse problem of converting pixel-wise multispectral…

Uncertainty estimation is important for interpreting the trustworthiness of machine learning models in many applications. This is especially critical in the data-driven active learning setting where the goal is to achieve a certain accuracy…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Bo Li , Tommy Sonne Alstrøm

Oral squamous cell carcinoma (OSCC) represents a significant global health concern, with increasing incidence rates and challenges in early diagnosis and treatment planning. Early detection is crucial for improving patient outcomes and…

Image and Video Processing · Electrical Eng. & Systems 2024-08-20 Samrat Kumar Dev Sharma

Multi-task neural network architectures provide a mechanism that jointly integrates information from distinct sources. It is ideal in the context of MR-only radiotherapy planning as it can jointly regress a synthetic CT (synCT) scan and…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Felix J. S. Bragman , Ryutaro Tanno , Zach Eaton-Rosen , Wenqi Li , David J. Hawkes , Sebastien Ourselin , Daniel C. Alexander , Jamie R. McClelland , M. Jorge Cardoso

Identifying and disentangling sources of predictive uncertainty is essential for trustworthy supervised learning. We argue that widely used second-order methods that disentangle aleatoric and epistemic uncertainty are fundamentally…

Machine Learning · Computer Science 2026-02-09 Sebastián Jiménez , Mira Jürgens , Willem Waegeman

The superior performance of object detectors is often established under the condition that the test samples are in the same distribution as the training data. However, in many practical applications, out-of-distribution (OOD) instances are…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Tianhao Zhang , Shenglin Wang , Nidhal Bouaynaya , Radu Calinescu , Lyudmila Mihaylova

Decomposing prediction uncertainty into aleatoric (irreducible) and epistemic (reducible) components is critical for the reliable deployment of machine learning systems. While the mutual information between the response variable and model…

Machine Learning · Statistics 2026-02-10 Anchit Jain , Stephen Bates

Accurate estimation of tacrolimus exposure, quantified by the area under the concentration-time curve (AUC), is essential for precision dosing after renal transplantation. Current practice relies on population pharmacokinetic (PopPK) models…

Machine Learning · Statistics 2026-02-04 Benjamin Maurel , Agathe Guilloux , Sarah Zohar , Moreno Ursino , Jean-Baptiste Woillard

Geometric uncertainty can degrade treatment quality in radiation therapy. While margins and robust optimization mitigate these effects, they provide only implicit control over clinical goal fulfillment probability. We therefore develop a…

Medical Physics · Physics 2026-01-14 Albin Fredriksson , Erik Engwall , Jenneke de Jong , Johan Sundström

We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to…

Tissues and Organs · Quantitative Biology 2015-06-05 Hamidreza Badri , Yoichi Watanabe , Kevin Leder