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Medical imaging has played a pivotal role in advancing and refining digital twin technology, allowing for the development of highly personalized virtual models that represent human anatomy and physiological functions. A key component in…

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Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

Virtual patients and digital patients/twins are two similar concepts gaining increasing attention in health care with goals to accelerate drug development and improve patients' survival, but with their own limitations. Although methods have…

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Digital twin models are of high interest to Head and Neck Cancer (HNC) oncologists, who have to navigate a series of complex treatment decisions that weigh the efficacy of tumor control against toxicity and mortality risks. Evaluating…

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With the widespread adoption of AI, machine-to-machine communications are rapidly increasing, reshaping the requirements for optical networks. Recent advances in Gaussian noise modeling for digital coherent transmission have raised…

Artificial Intelligence (AI) technology is based on theory and development of computer systems able to perform tasks that normally require human intelligence. In this context, deep learning is a family of computational methods that allow an…

Computers and Society · Computer Science 2019-05-17 Mario Coccia

Advances in Automation and Artificial Intelligence continue to enhance the autonomy of process plants in handling various operational scenarios. However, certain tasks, such as fault handling, remain challenging, as they rely heavily on…

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This article presents the general framework of theranostic digital twins (TDTs) in computational nuclear medicine, designed to support clinical decision-making and improve cancer patient prognosis through personalized radiopharmaceutical…

Other Quantitative Biology · Quantitative Biology 2025-11-07 Marc Ryhiner , Yangmeihui Song , Babak Saboury , Gerhard Glatting , Arman Rahmim , Kuangyu Shi

The growing complexity of healthcare systems requires advanced computational models for real-time monitoring, secure data exchange, and intelligent decision-making. Digital Twins (DTs) provide virtual representations of physical healthcare…

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Radioembolization is a localized liver cancer treatment that delivers radioactive microspheres (30 micron) to tumors via a catheter inserted in the hepatic arterial tree. The goal is to maximize therapeutic efficacy while minimizing damage…

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We develop a methodology to create data-driven predictive digital twins for optimal risk-aware clinical decision-making. We illustrate the methodology as an enabler for an anticipatory personalized treatment that accounts for uncertainties…

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Recent advances in large language models (LLMs) have demonstrated strong capabilities in software engineering tasks, raising expectations of revolutionary productivity gains. However, enterprise software development is largely driven by…

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Personalized chronic care requires the integration of multimodal health data to enable precise, adaptive, and preventive decision-making. Yet most current digital twin (DT) applications remain organ-specific or tied to isolated data types,…

Software Engineering · Computer Science 2025-10-13 Amal Elgammal , Bernd J. Krämer , Michael P. Papazoglou , Mira Raheem

Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital…

Artificial Intelligence · Computer Science 2017-12-20 Andreas Holzinger , Bernd Malle , Peter Kieseberg , Peter M. Roth , Heimo Müller , Robert Reihs , Kurt Zatloukal

As telecommunications networks become increasingly complex, the integration of advanced technologies such as network digital twins and generative artificial intelligence (AI) emerges as a pivotal solution to enhance network operations and…

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Recent advances in AI coding tools powered by large language models (LLMs) have shown strong capabilities in software engineering tasks, raising expectations of major productivity gains. Tools such as Cursor and Claude Code have popularized…

Software Engineering · Computer Science 2026-02-03 Xin Peng , Chong Wang

The combination of data and models, enhanced by AI methodologies, leads to the paradigm called Digital Twins. This concept is expected to bring unprecedented support to personalized medicine. The combination of mathematical and numerical…

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Medical digital twins are computational models of human biology relevant to a given medical condition, which can be tailored to an individual patient, thereby predicting the course of disease and individualized treatments, an important goal…

The envisioned 6G networks are expected to support extremely high data rates, low-latency, and radically new applications empowered by machine learning. The futuristic 6G networks require a novel framework that can be used to operate,…

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