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The dynamics of cellular aggregates is driven by the interplay of mechanochemical processes and cellular activity. Although deterministic models may capture mechanical features, local chemical fluctuations trigger random cell responses,…

Soft Condensed Matter · Physics 2024-01-17 Ana Carpio , Elena Cebrian

Our understanding of cell division control in bacteria still relies largely on interpreting correlations between phenomenological variables, with limited connection to the underlying molecular mechanisms. Here, we analytically solve a…

An important task in quantitative biology is to understand the role of stochasticity in biochemical regulation. Here, as an extension of our recent work [Phys. Rev. Lett. 107, 148101 (2011)], we study how input fluctuations affect the…

Molecular Networks · Quantitative Biology 2015-06-11 Bo Hu , David A. Kessler , Wouter-Jan Rappel , Herbert Levine

At the macroscopic scale, many important models of collective motion fall into the class of kinematic flows for which both velocity and diffusion terms depend only on particle density. When total particle numbers are fixed and finite,…

Adaptation and Self-Organizing Systems · Physics 2022-04-12 Jeremy Worsfold , Tim Rogers , Paul Milewski

In this paper, we address the inherent limitations in traditional assembly line balancing, specifically the assumptions that task times are constant and no defective outputs occur. These assumptions often do not hold in practical scenarios,…

Performance · Computer Science 2025-03-31 Gazi Nazia Nur , Mohammad Ahnaf Sadat , Basit Mahmud Shahriar

In this work, we present a novel inner product design for stochastic computing. Stochastic computing is an emerging computing technique, that encodes a number in the probability of observing a one in a random bit stream. This leads to…

Emerging Technologies · Computer Science 2018-11-21 Werner Haselmayr , Daniel Wiesinger , Michael Lunglmayr

We analyze the stochastic response of a finite set of globally coupled noisy bistable units driven by rather weak time-periodic forces. We focus on the stochastic resonance and phase frequency synchronization of the collective variable,…

Statistical Mechanics · Physics 2009-11-13 Manuel Morillo , Jose Gomez-Ordonez Jose Manuel Casado

Understanding under which conditions the increase of systems complexity is evolutionary advantageous, and how this trend is related to the modulation of the intrinsic noise, are fascinating issues of utmost importance for synthetic and…

Molecular Networks · Quantitative Biology 2018-08-01 Fabrizio Pucci , Marianne Rooman

We discuss various measures of net charge (conserved quantities) fluctuations proposed for the identification of critical phenomena in heavy ion collisions. We show the dynamical component of fluctuations of the net charge can be expressed…

Nuclear Experiment · Physics 2009-11-07 C. Pruneau , S. Gavin , S. Voloshin

Living systems often function with regulatory interactions, but the question of how activity, stochasticity and regulations work together for achieving different goals still remains puzzling. We propose a stochastic model of an active…

Soft Condensed Matter · Physics 2026-03-02 Tai Han , Fanlong Meng

Fluctuation relations are powerful equalities that hold far from equilibrium. However, the standard approach to include measurement and feedback schemes may become inapplicable in certain situations, including continuous measurements,…

Mesoscale and Nanoscale Physics · Physics 2019-09-05 Patrick P. Potts , Peter Samuelsson

We study the statistical properties of charge and energy transport in electron conducting junctions with electron-phonon interactions, specifically, the thermoelectric efficiency and its fluctuations. The system comprises donor and acceptor…

Statistical Mechanics · Physics 2016-01-20 Bijay Kumar Agarwalla , Jian-Hua Jiang , Dvira Segal

We consider two seemingly very different self-assembly processes: formation of viral capsids, and crystallization of sticky discs. At low temperatures, assembly is ineffective, since there are many metastable disordered states, which are a…

Statistical Mechanics · Physics 2007-08-22 Robert L. Jack , Michael F. Hagan , David Chandler

In the standard framework of thermodynamics the work produced or consumed in a process is a random variable whose average value is bounded by the change in the free energy of the system. This work is calculated without regard for the size…

Quantum Physics · Physics 2017-04-19 Jonathan G. Richens , Lluis Masanes

How can a microorganism adapt to a variety of environmental conditions despite there exists a limited number of signal transduction machineries? We show that for any growing cells whose gene expression is under stochastic fluctuations,…

Molecular Networks · Quantitative Biology 2015-05-13 Chikara Furusawa , Kunihiko Kaneko

We consider the paradigm of an overdamped Brownian particle in a potential well, which is modulated through an external protocol, in the presence of stochastic resetting. Thus, in addition to the short range diffusive motion, the particle…

Statistical Mechanics · Physics 2020-03-25 Deepak Gupta , Carlos A. Plata , Arnab Pal

Intracellular biochemical networks fluctuate dynamically due to various internal and external sources of fluctuation. Dissecting the fluctuation into biologically relevant components is important for understanding how a cell controls and…

Molecular Networks · Quantitative Biology 2016-02-17 Tetsuya J. Kobayashi , Ryo Yokota , Kazuyuki Aihara

Biological systems sense and extract information from fluctuating signals while operating under energetic constraints and limited resolution. We introduce a general chemical model in which a sensor, coupled to a signaling pathway activated…

Statistical Mechanics · Physics 2025-12-09 Giorgio Nicoletti , Ivan Di Terlizzi , Daniel Maria Busiello

We derive the general probability distribution function of stochastic work for quantum Otto engines in which both the isochoric and driving processes are irreversible due to finite time duration. The time-dependent power fluctuations,…

Statistical Mechanics · Physics 2021-03-24 Guangqian Jiao , Shoubao Zhu , Jizhou He , Yongli Ma , Jianhui Wang

The influence of dissipation on the fluctuation statistics of the total energy is investigated through both a phenomenological and a stochastic model for dissipative energy-transfer through a cascade of states. In equilibrium the states…

Statistical Mechanics · Physics 2013-06-27 Eric Bertin , Peter C. W. Holdsworth