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Flow cytometry measurements are widely used in diagnostics and medical decision making. Incomplete understanding of sources of measurement uncertainty can make it difficult to distinguish autofluorescence and background sources from signals…

Quantitative Methods · Quantitative Biology 2024-12-02 Prajakta Bedekar , Megan A. Catterton , Matthew DiSalvo , Gregory A. Cooksey , Anthony J. Kearsley , Paul N. Patrone

Signals analysis for cytometry remains a challenging task that has a significant impact on uncertainty. Conventional cytometers assume that individual measurements are well characterized by simple properties such as the signal area, width,…

Flow cytometry mainly used for detecting the characteristics of a number of biochemical substances based on the expression of specific markers in cells. It is particularly useful for detecting membrane surface receptors, antigens, ions, or…

Machine Learning · Computer Science 2023-03-17 Yanhua Xu

The measurement of data over time and/or space is of utmost importance in a wide range of domains from engineering to physics. Devices that perform these measurements therefore need to be extremely precise to obtain correct system…

Standard uncertainty estimation techniques, such as dropout, often struggle to clearly distinguish reliable predictions from unreliable ones. We attribute this limitation to noisy classifier weights, which, while not impairing overall…

Machine Learning · Computer Science 2025-06-09 Haripriya Harikumar , Santu Rana

Although microarrays are routine analysis tools in biomedical research, they still yield noisy output that often requires experimental confirmation. Many studies have aimed at optimizing probe design and statistical analysis to tackle this…

Quantitative Methods · Quantitative Biology 2015-06-15 Alex E Pozhitkov , Peter A Noble , Jaroslaw Bryk , Diethard Tautz

It is widely known in the machine learning community that class noise can be (and often is) detrimental to inducing a model of the data. Many current approaches use a single, often biased, measurement to determine if an instance is noisy. A…

Machine Learning · Statistics 2014-03-11 Michael R. Smith , Tony Martinez

Flow cytometry is a widespread single-cell measurement technology with a multitude of clinical and research applications. Interpretation of flow cytometry data is hard; the instrumentation is delicate and can not render absolute…

Applications · Statistics 2015-02-16 Jonas Wallin , Kerstin Johnsson , Magnus Fontes

One limitation on the performance of optical traps is the noise inherently present in every setup. Therefore, it is the desire of most experimentalists to minimize and possibly eliminate noise from their optical trapping experiments. A step…

Data Analysis, Statistics and Probability · Physics 2009-09-01 Fabian Czerwinski , Andrew C. Richardson , Christine Selhuber-Unkel , Lene B. Oddershede

Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…

Biomolecules · Quantitative Biology 2015-04-15 Mark Leake

Flow cytometry is a valuable technique that measures the optical properties of particles at a single-cell resolution. When deployed in the ocean, flow cytometry allows oceanographers to study different types of photosynthetic microbes…

Methodology · Statistics 2026-04-02 Ethan Pawl , François Ribalet , Paul A. Parker , Sangwon Hyun

Science students must deal with the errors inherent to all physical measurements and be conscious of the need to expressvthem as a best estimate and a range of uncertainty. Errors are routinely classified as statistical or systematic.…

Physics Education · Physics 2021-05-05 Martin Monteiro , Cecilia Stari , Cecilia Cabeza , Arturo C. Marti

We introduce a new approach for estimating the invariant density of a multidimensional diffusion when dealing with high-frequency observations blurred by independent noises. We consider the intermediate regime, where observations occur at…

Statistics Theory · Mathematics 2024-04-19 Raphaël Maillet , Grégoire Szymanski

A hierarchy of statistics of increasing sophistication and accuracy is proposed, to exploit an interesting and fundamental arithmetic structure in the photon bunching noise of incoherent light of large photon occupation number, with the…

Instrumentation and Methods for Astrophysics · Physics 2017-08-02 Richard Lieu

The noise of a device under test (DUT) is measured simultaneously with two instruments, each of which contributes its own background. The average cross power spectral density converges to the DUT power spectral density. This method enables…

Instrumentation and Detectors · Physics 2010-03-02 Enrico Rubiola , Francois Vernotte

This article presents an algorithm for reducing measurement uncertainty of one physical quantity when given oversampled measurements of two physical quantities with correlated noise. The algorithm assumes that the aleatoric measurement…

Signal Processing · Electrical Eng. & Systems 2021-11-30 James T. Meech , Phillip Stanley-Marbell

You measure the value of a quantity x for a number of systems (cells, molecules, people, chunks of metal, DNA vectors, etc.). You repeat the whole set of measures in different occasions or assays, which you try to design as equal to one…

Quantitative Methods · Quantitative Biology 2013-11-04 Pablo Echenique-Robba , María Alejandra Nelo-Bazán , José A. Carrodeguas

Quantifying uncertainty in detected changepoints is an important problem. However it is challenging as the naive approach would use the data twice, first to detect the changes, and then to test them. This will bias the test, and can lead to…

Methodology · Statistics 2026-05-11 Rachel Carrington , Paul Fearnhead

Bursting cells lead to ambient RNA that contaminates sequencing data. This process is especially problematic in perturbation experiments where transcription factors are implanted into cells to determine their effects. The presence of…

Quantitative Methods · Quantitative Biology 2023-09-21 Forrest Sheldon

Instrumental playing techniques such as vibratos, glissandos, and trills often denote musical expressivity, both in classical and folk contexts. However, most existing approaches to music similarity retrieval fail to describe timbre beyond…

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