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Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…

Medical Physics · Physics 2025-08-13 Malvern Madondo , Yuan Shao , Yingzi Liu , Jun Zhou , Xiaofeng Yang , Zhen Tian

Modern precision medicine aims to utilize real-world data to provide the best treatment for an individual patient. An individualized treatment rule (ITR) maps each patient's characteristics to a recommended treatment scheme that maximizes…

Applications · Statistics 2025-01-07 Andong Wang , Kelly Wentzlof , Johnny Rajala , Miontranese Green , Yunshu Zhang , Shu Yang

Determining the optimal initial dose for warfarin is a critically important task. Several factors have an impact on the therapeutic dose for individual patients, such as patients' physical attributes (Age, Height, etc.), medication profile,…

Machine Learning · Computer Science 2019-03-25 Ashkan Sharabiani , Adam Bress , William Galanter , Rezvan Nazempour , Houshang Darabi

Reinforcement learning algorithms have had tremendous successes in online learning settings. However, these successes have relied on low-stakes interactions between the algorithmic agent and its environment. In many settings where RL could…

Machine Learning · Computer Science 2020-06-05 James Bannon , Brad Windsor , Wenbo Song , Tao Li

Reinforcement learning (RL) tasks are typically framed as Markov Decision Processes (MDPs), assuming that decisions are made at fixed time intervals. However, many applications of great importance, including healthcare, do not satisfy this…

Clinical diagnosis guidelines aim at specifying the steps that may lead to a diagnosis. Inspired by guidelines, we aim to learn the optimal sequence of actions to perform in order to obtain a correct diagnosis from electronic health…

Machine Learning · Computer Science 2023-11-16 Lillian Muyama , Antoine Neuraz , Adrien Coulet

This work studies a Reinforcement Learning (RL) problem in which we are given a set of trajectories collected with K baseline policies. Each of these policies can be quite suboptimal in isolation, and have strong performance in…

Machine Learning · Computer Science 2024-03-29 Teodor V. Marinov , Alekh Agarwal , Mircea Trofin

Sepsis is the leading cause of mortality in the ICU. It is challenging to manage because individual patients respond differently to treatment. Thus, tailoring treatment to the individual patient is essential for the best outcomes. In this…

Reinforcement learning (RL) is a promising tool to solve robust optimal well control problems where the model parameters are highly uncertain, and the system is partially observable in practice. However, RL of robust control policies often…

Machine Learning · Computer Science 2022-07-14 Atish Dixit , Ahmed H. ElSheikh

Deep reinforcement learning algorithms have succeeded in several challenging domains. Classic Online RL job schedulers can learn efficient scheduling strategies but often takes thousands of timesteps to explore the environment and adapt…

Machine Learning · Computer Science 2022-12-05 Vanamala Venkataswamy , Jake Grigsby , Andrew Grimshaw , Yanjun Qi

This paper presents a hierarchical reinforcement learning (RL) approach to address the agent grouping or pairing problem in cooperative multi-agent systems. The goal is to simultaneously learn the optimal grouping and agent policy. By…

Machine Learning · Computer Science 2025-01-14 Liyuan Hu

Hierarchical reinforcement learning (HRL) is a promising approach to extend traditional reinforcement learning (RL) methods to solve more complex tasks. Yet, the majority of current HRL methods require careful task-specific design and…

Machine Learning · Computer Science 2018-10-08 Ofir Nachum , Shixiang Gu , Honglak Lee , Sergey Levine

We consider the problem of reinforcement learning when provided with (1) a baseline control policy and (2) a set of constraints that the learner must satisfy. The baseline policy can arise from demonstration data or a teacher agent and may…

Machine Learning · Computer Science 2021-07-13 Tsung-Yen Yang , Justinian Rosca , Karthik Narasimhan , Peter J. Ramadge

We study the offline reinforcement learning (RL) in the face of unmeasured confounders. Due to the lack of online interaction with the environment, offline RL is facing the following two significant challenges: (i) the agent may be…

Machine Learning · Computer Science 2022-09-20 Zuyue Fu , Zhengling Qi , Zhaoran Wang , Zhuoran Yang , Yanxun Xu , Michael R. Kosorok

Inverse Reinforcement Learning (IRL) -- the problem of learning reward functions from demonstrations of an \emph{expert policy} -- plays a critical role in developing intelligent systems. While widely used in applications, theoretical…

Machine Learning · Statistics 2024-02-13 Lei Zhao , Mengdi Wang , Yu Bai

Reinforcement Learning (RL) has the promise of providing data-driven support for decision-making in a wide range of problems in healthcare, education, business, and other domains. Classical RL methods focus on the mean of the total return…

Machine Learning · Computer Science 2022-02-02 Elynn Y. Chen , Rui Song , Michael I. Jordan

Non-coplanar Intensity-Modulated Radiation Therapy (IMRT) goes a step further by orienting the gantry carrying the radiation beam and the patient couch in a non-coplanar manner to accurately target the cancer region and better avoid…

Medical Physics · Physics 2023-05-16 Fang Guo , Franklin Okoli , Ulrike Schick , Dimitris Visvikis , Antoine Valeri , Julien Bert

Imagine if AI decision-support tools not only complemented our ability to make accurate decisions, but also improved our skills, boosted collaboration, and elevated the joy we derive from our tasks. Despite the potential to optimize a broad…

Human-Computer Interaction · Computer Science 2024-04-16 Zana Buçinca , Siddharth Swaroop , Amanda E. Paluch , Susan A. Murphy , Krzysztof Z. Gajos

The optimal strategy for deploying a treatment in a population may recommend giving all in the population that treatment. Such a strategy may not be feasible, especially in resource-limited settings. One approach for determining how to…

Applications · Statistics 2025-02-21 Lina M. Montoya , Elvin H. Geng , Harriet F. Adhiambo , Maya L. Petersen

In this survey, we systematically summarize the current literature on studies that apply reinforcement learning (RL) to the motion planning and control of autonomous vehicles. Many existing contributions can be attributed to the pipeline…

Robotics · Computer Science 2021-06-02 Fei Ye , Shen Zhang , Pin Wang , Ching-Yao Chan
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