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In medical image analysis, regression plays a critical role in computer-aided diagnosis. It enables quantitative measurements such as age prediction from structural imaging, cardiac function quantification, and molecular measurement from…

Machine Learning · Computer Science 2025-03-25 Yilei Wu , Zijian Dong , Chongyao Chen , Wangchunshu Zhou , Juan Helen Zhou

Computational pathology models that use digitized histopathology whole-slide images have the potential to become a cost-effective and scalable alternative to molecular assays for the prediction of genomic biomarkers, a key task in precision…

Quantitative Methods · Quantitative Biology 2026-03-03 Ekaterina Redekop , Eric Zimmermann , Ava P Amini , Alex X Lu , Neil Tenenholtz , James Brian Hall , Lorin Crawford , Kristen A Severson

In healthcare, it is essential to explain the decision-making process of machine learning models to establish the trustworthiness of clinicians. This paper introduces BI-RADS-Net, a novel explainable deep learning approach for cancer…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Boyu Zhang , Aleksandar Vakanski , Min Xian

Lung nodule malignancy prediction has been enhanced by advanced deep-learning techniques and effective tricks. Nevertheless, current methods are mainly trained with cross-entropy loss using one-hot categorical labels, which results in…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Yiming Lei , Zilong Li , Yan Shen , Junping Zhang , Hongming Shan

Contrastive learning is a form of self-supervision that can leverage unlabeled data to produce pretrained models. While contrastive learning has demonstrated promising results on natural image classification tasks, its application to…

Computer Vision and Pattern Recognition · Computer Science 2021-05-19 Hari Sowrirajan , Jingbo Yang , Andrew Y. Ng , Pranav Rajpurkar

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Chenglong Wang , Yinqiao Yi , Yida Wang , Chengxiu Zhang , Yun Liu , Kensaku Mori , Mei Yuan , Guang Yang

Breast cancer is the second leading cause of cancer-related death after lung cancer in women. Early detection of breast cancer in X-ray mammography is believed to have effectively reduced the mortality rate. However, a relatively high false…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Xuejiao Tang , Liuhua Zhang , Wenbin Zhang , Xin Huang , Vasileios Iosifidis , Zhen Liu , Mingli Zhang , Enza Messina , Ji Zhang

Contrastive Language-Image Pre-training (CLIP) demonstrates strong potential in medical image analysis but requires substantial data and computational resources. Due to these restrictions, existing CLIP applications in medical imaging focus…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Yuexi Du , John Onofrey , Nicha C. Dvornek

Building a highly accurate predictive model for classification and localization of abnormalities in chest X-rays usually requires a large number of manually annotated labels and pixel regions (bounding boxes) of abnormalities. However, it…

Computer Vision and Pattern Recognition · Computer Science 2022-05-06 Yan Han , Chongyan Chen , Ahmed Tewfik , Benjamin Glicksberg , Ying Ding , Yifan Peng , Zhangyang Wang

Representation learning constitutes a pivotal cornerstone in contemporary deep learning paradigms, offering a conduit to elucidate distinctive features within the latent space and interpret the deep models. Nevertheless, the inherent…

Computer Vision and Pattern Recognition · Computer Science 2024-02-07 Siyuan Dai , Kai Ye , Kun Zhao , Ge Cui , Haoteng Tang , Liang Zhan

Contrastive learning has emerged as an essential approach for self-supervised learning in visual representation learning. The central objective of contrastive learning is to maximize the similarities between two augmented versions of an…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Hengkui Dong , Xianzhong Long , Yun Li , Lei Chen

Clustering continues to be a significant and challenging task. Recent studies have demonstrated impressive results by applying clustering to feature representations acquired through self-supervised learning, particularly on small datasets.…

Machine Learning · Computer Science 2023-07-19 Fei Ding , Dan Zhang , Yin Yang , Venkat Krovi , Feng Luo

Multiple instance (MI) learning with a convolutional neural network enables end-to-end training in the presence of weak image-level labels. We propose a new method for aggregating predictions from smaller regions of the image into an…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Heather D. Couture , J. S. Marron , Charles M. Perou , Melissa A. Troester , Marc Niethammer

Deep candidate generation (DCG) that narrows down the collection of relevant items from billions to hundreds via representation learning has become prevalent in industrial recommender systems. Standard approaches approximate maximum…

Information Retrieval · Computer Science 2021-06-07 Chang Zhou , Jianxin Ma , Jianwei Zhang , Jingren Zhou , Hongxia Yang

Breast cancer is one of the leading causes of death among women across the globe. It is difficult to treat if detected at advanced stages, however, early detection can significantly increase chances of survival and improves lives of…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Unaiza Sajid , Rizwan Ahmed Khan , Shahid Munir Shah , Sheeraz Arif

Multimodal contrastive learning is a methodology for linking different data modalities; the canonical example is linking image and text data. The methodology is typically framed as the identification of a set of encoders, one for each…

Machine Learning · Statistics 2025-06-02 Ricardo Baptista , Andrew M. Stuart , Son Tran

With large-scale well-labeled datasets, deep learning has shown significant success in medical image segmentation. However, it is challenging to acquire abundant annotations in clinical practice due to extensive expertise requirements and…

Image and Video Processing · Electrical Eng. & Systems 2022-10-20 Ziyuan Zhao , Jinxuan Hu , Zeng Zeng , Xulei Yang , Peisheng Qian , Bharadwaj Veeravalli , Cuntai Guan

Citrus, as one of the most economically important fruit crops globally, suffers severe yield depressions due to various diseases. Accurate disease detection and classification serve as critical prerequisites for implementing targeted…

Computer Vision and Pattern Recognition · Computer Science 2025-07-16 Jun Chen , Yonghua Yu , Weifu Li , Yaohui Chen , Hong Chen

Breast cancer is the most common invasive cancer in women, and the second main cause of death. Breast cancer screening is an efficient method to detect indeterminate breast lesions early. The common approaches of screening for women are…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Yuliana Jiménez Gaona , María José Rodriguez-Alvarez , Hector Espinó Morató , Darwin Castillo Malla , Vasudevan Lakshminarayanan

How can you sample good negative examples for contrastive learning? We argue that, as with metric learning, contrastive learning of representations benefits from hard negative samples (i.e., points that are difficult to distinguish from an…

Machine Learning · Computer Science 2021-01-26 Joshua Robinson , Ching-Yao Chuang , Suvrit Sra , Stefanie Jegelka