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The answers to many unsolved problems lie in the intractable chemical space of molecules and materials. Machine learning techniques are rapidly growing in popularity as a way to compress and explore chemical space efficiently. One of the…

Chemical Physics · Physics 2020-01-06 John E. Herr , Kevin Koh , Kun Yao , John Parkhill

Simplicial complexes form an important class of topological spaces that are frequently used in many application areas such as computer-aided design, computer graphics, and simulation. Representation learning on graphs, which are just 1-d…

Machine Learning · Computer Science 2022-02-03 Mustafa Hajij , Ghada Zamzmi , Theodore Papamarkou , Vasileios Maroulas , Xuanting Cai

Deep Learning has been shown to learn efficient representations for structured data such as image, text or audio. In this chapter, we present neural network architectures that are able to learn efficient representations of molecules and…

Computational Physics · Physics 2018-12-13 Kristof T. Schütt , Alexandre Tkatchenko , Klaus-Robert Müller

High-performance machine learning tools in particle physics rest on two complementary directions: encoding symmetries explicitly in the architecture, and implicitly learning the structure of the data through large-scale (pre-) training. We…

High Energy Physics - Phenomenology · Physics 2026-03-23 Victor Breso-Pla , Kevin Greif , Vinicius Mikuni , Benjamin Nachman , Tilman Plehn , Tanvi Wamorkar , Daniel Whiteson

Machine learning has emerged as a powerful approach in materials discovery. Its major challenge is selecting features that create interpretable representations of materials, useful across multiple prediction tasks. We introduce an…

Atomic-level modeling performed at large scales enables the investigation of mesoscale materials properties with atom-by-atom resolution. The spatial complexity of such cross-scale simulations renders them unsuitable for simple human visual…

Materials Science · Physics 2022-04-05 Heejung Chung , Rodrigo Freitas , Gowoon Cheon , Evan J. Reed

Evaluating the quality of learned representations without relying on a downstream task remains one of the challenges in representation learning. In this work, we present Geometric Component Analysis (GeomCA) algorithm that evaluates…

Machine Learning · Computer Science 2021-05-27 Petra Poklukar , Anastasia Varava , Danica Kragic

Polymers are widely-studied materials with diverse properties and applications determined by different molecular structures. It is essential to represent these structures clearly and explore the full space of achievable chemical designs.…

Chemical Physics · Physics 2021-05-13 Minghao Guo , Wan Shou , Liane Makatura , Timothy Erps , Michael Foshey , Wojciech Matusik

Hypergraphs provide a natural way to represent polyadic relationships in network data. For large hypergraphs, it is often difficult to visually detect structures within the data. Recently, a scalable polygon-based visualization approach was…

Graphics · Computer Science 2024-07-30 Peter Oliver , Eugene Zhang , Yue Zhang

Models of complicated systems can be represented in different ways - in scientific papers, they are represented using natural language text as well as equations. But to be of real use, they must also be implemented as software, thus making…

Hamiltonian mechanics is an effective tool to represent many physical processes with concise yet well-generalized mathematical expressions. A well-modeled Hamiltonian makes it easy for researchers to analyze and forecast many related…

Machine Learning · Computer Science 2021-02-24 Seungjun Lee , Haesang Yang , Woojae Seong

Neural networks encode inputs as high-dimensional vectors, known as representations, that capture how models process data by encoding task-relevant structure and semantics. Representation alignment refers to the degree to which different…

Computational Geometry · Computer Science 2026-05-26 Xinyuan Yan , Rita Sevastjanova , Mennatallah El-Assady , Bei Wang

Faithfully representing chemical environments is essential for describing materials and molecules with machine learning approaches. Here, we present a systematic classification of these representations and then investigate: (i) the…

Materials Science · Physics 2020-10-28 Berk Onat , Christoph Ortner , James R. Kermode

A new method is presented to generate atomic structures that reproduce the essential characteristics of arbitrary material systems, phases, or ensembles. Previous methods allow one to reproduce the essential characteristics (e.g. chemical…

Materials Science · Physics 2024-09-24 James M. Goff , Coreen Mullen , Shizhong Yang , Oleg N. Starovoytov , Mitchell A. Wood

In the past two decades, machine learning potentials (MLP) have reached a level of maturity that now enables applications to large-scale atomistic simulations of a wide range of systems in chemistry, physics and materials science. Different…

Chemical Physics · Physics 2021-07-09 Emir Kocer , Tsz Wai Ko , Jörg Behler

Topological data analysis refers to approaches for systematically and reliably computing abstract ``shapes'' of complex data sets. There are various applications of topological data analysis in life and data sciences, with growing interest…

Mesoscale and Nanoscale Physics · Physics 2023-07-26 Daniel Leykam , Dimitris G. Angelakis

The mathematical formalisms used to model biological systems induce both latent and ambiguous assumptions that can limit or distort their representational capabilities. Developing formalisms that can represent systems more precisely is…

Quantitative Methods · Quantitative Biology 2026-05-25 Léo Diaz , Sean T. Vittadello , Michael P. H. Stumpf

Machine-learning generative methods for material design are constructed by representing a given chemical structure, either a solid or a molecule, over appropriate atomic features, generally called structural descriptors. These must be fully…

Materials Science · Physics 2022-07-20 Matteo Cobelli , Paddy Cahalane , Stefano Sanvito

We develop inductive biases for the machine learning of complex physical systems based on the port-Hamiltonian formalism. To satisfy by construction the principles of thermodynamics in the learned physics (conservation of energy,…

Machine Learning · Computer Science 2023-03-28 Quercus Hernández , Alberto Badías , Francisco Chinesta , Elías Cueto

Encoding the electronic structure of molecules using 2-electron reduced density matrices (2RDMs) as opposed to many-body wave functions has been a decades-long quest as the 2RDM contains sufficient information to compute the exact molecular…

Chemical Physics · Physics 2022-08-11 David Pekker , Chungwen Liang , Sankha Pattanayak , Swagatam Mukhopadhyay