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Modern scientific instruments operate under increasingly extreme constraints on bandwidth, latency, and power. Inference at the sensor edge determines experimental data collection efficiency by deciding which information to save for further…

Biomarker detection is the key to identifying health risks. However, designing sensitive biosensors in a single-use mode for disease diagnosis remains a major challenge. Here, we report sub-monolayer biolasers with remarkable repeatability…

The rapid development of coherent short-wavelength light sources in the extreme ultraviolet (EUV) and soft X-ray (SXR) regimes has created a growing need for advanced optoelectronic detection capabilities, particularly for…

Instrumentation and Detectors · Physics 2026-05-26 Ivan Ryger , Terry Brown , Dina S. Eissa , Chen-Ting Liao

Cell-based biosensors constitute a fundamental tool in biotechnology, and their relevance has greatly increased in recent years as a result of a surging demand for reduced animal testing and for high-throughput and cost-effective in vitro…

Integration is currently the only feasible route towards scalable photonic quantum processing devices that are sufficiently complex to be genuinely useful in computing, metrology, and simulation. Embedded on-chip detection will be critical…

Segmenting biomarkers in medical images is crucial for various biotech applications. Despite advances, Transformer and CNN based methods often struggle with variations in staining and morphology, limiting feature extraction. In medical…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Saad Wazir , Daeyoung Kim

Defect centers are promising candidates for waveguide-integrated silicon light sources. We demonstrate microresonator- and waveguide-coupled photoluminescence from silicon W~centers. Microphotoluminescence measurements indicate wavelengths…

Quantum biosensors offer a promising route to overcome the sensitivity and specificity limitations of conventional biosensing technologies. Their ability to detect biochemical signals at extremely low concentrations makes them strong…

Optics · Physics 2025-08-05 Yasaman Torabi , Shahram Shirani , James P. Reilly

In the last years, high-resolution time tagging has emerged as the tool to tackle the problem of high-track density in the detectors of the next generation of experiments at particle colliders. Time resolutions below 50ps and event average…

Integrated photonics provides a route both to miniaturize quantum key distribution (QKD) devices and to enhance their performance. A key element for achieving discrete-variable QKD is a single-photon detector. It is highly desirable to…

Microelectronic integration is a key enabler for the ubiquitous deployment of devices in large volumes ranging from MEMS and imaging sensors to consumer electronics. Such integration has also been achieved in photonics, where compact…

The basic principle of operation of silicon sensors with resistive read-out is built-in charge sharing. Resistive Silicon Detectors (RSD, also known as AC-LGAD), exploiting the signals seen on the electrodes surrounding the impact point,…

Bacteria sense a diverse range of environmental analytes with high sensitivity and temporal resolution. Engineering and synthetic biology approaches enabled harnessing this capability through development of whole-cell biosensors that…

Optical sensors offer precision, remote read-out, and immunity to electromagnetic interference but face adoption challenges due to complex and costly readout instrumentation, mostly based on high-resolution. This article challenges the…

Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability of plasmonic systems to confine the light in nanometer volume and…

We present systematic and efficient solutions for both observability enhancement and root-cause diagnosis of post-silicon System-on-Chips (SoCs) validation with diverse usage scenarios. We model specification of interacting flows in typical…

Hardware Architecture · Computer Science 2021-02-10 Debjit Pal , Shobha Vasudevan

We propose a conceptual device for multiplexed biosensor in a photonic crystal chip based on the Su-Schrieffer-Heeger mechanism. Remarkably, the proposed biosensor can identify three distinct disease markers through a single-shot photon…

Optics · Physics 2024-08-12 Yang Liu , Jian-Hua Jiang

We discuss the performance of a readout system, Fixed Pulse Shape Efficient Readout (FIPSER), to digitize signals from detectors with a fixed pulse shape. In this study we are mainly interested in the readout of fast photon detectors like…

Instrumentation and Detectors · Physics 2016-09-16 Brent Limyansky , Robert Reese , John D. Cressler , Adam Nepomuk Otte , Ignacio Taboada , Cagri Ulusoy

Versatile, ultracompact, easy-to-handle, high-sensitivity sensors are compelling tools for in situ pivotal applications, such as medical diagnostics, security and safety assessments, and environmental control. In this work, we combine…

Nanoelectromechanical resonators have been successfully used for a variety of sensing applications. Their extreme resolution comes from their small size at the cost of low capture area, making the "needle in a haystack" issue acute. This…