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This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing…

Information Retrieval · Computer Science 2024-11-01 Georgios Peikos , Pranav Kasela , Gabriella Pasi

Large language models (LLMs) exhibit strong medical knowledge and can generate factually accurate responses. However, existing models often fail to account for individual patient contexts, producing answers that are clinically correct yet…

Computation and Language · Computer Science 2026-03-16 Po-Jen Ko , Chen-Han Tsai , Yu-Shao Peng

Large language models (LLMs) often struggle with context fidelity, producing inconsistent answers when responding to questions based on provided information. Existing approaches either rely on expensive supervised fine-tuning to generate…

Computation and Language · Computer Science 2025-09-18 Suyuchen Wang , Jinlin Wang , Xinyu Wang , Shiqi Li , Xiangru Tang , Sirui Hong , Xiao-Wen Chang , Chenglin Wu , Bang Liu

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Large Language Models (LLMs) have shown impressive capabilities in generating human-like responses. However, their lack of domain-specific knowledge limits their applicability in healthcare settings, where contextual and comprehensive…

Computation and Language · Computer Science 2024-03-14 Subash Neupane , Shaswata Mitra , Sudip Mittal , Noorbakhsh Amiri Golilarz , Shahram Rahimi , Amin Amirlatifi

There is a lack of benchmarks for evaluating large language models (LLMs) in long-form medical question answering (QA). Most existing medical QA evaluation benchmarks focus on automatic metrics and multiple-choice questions. While valuable,…

Computation and Language · Computer Science 2024-11-21 Pedram Hosseini , Jessica M. Sin , Bing Ren , Bryceton G. Thomas , Elnaz Nouri , Ali Farahanchi , Saeed Hassanpour

Objective: To enhance the efficiency and accuracy of information retrieval from pharmacovigilance (PV) databases by employing Large Language Models (LLMs) to convert natural language queries (NLQs) into Structured Query Language (SQL)…

Artificial Intelligence · Computer Science 2025-04-18 Jeffery L. Painter , Venkateswara Rao Chalamalasetti , Raymond Kassekert , Andrew Bate

Navigating health questions can be daunting in the modern information landscape. Large language models (LLMs) may provide tailored, accessible information, but also risk being inaccurate, biased or misleading. We present insights from 4…

Patient matching is the process of linking patients to appropriate clinical trials by accurately identifying and matching their medical records with trial eligibility criteria. We propose LLM-Match, a novel framework for patient matching…

Computation and Language · Computer Science 2025-03-26 Xiaodi Li , Shaika Chowdhury , Chung Il Wi , Maria Vassilaki , Xiaoke Liu , Terence T Sio , Owen Garrick , Young J Juhn , James R Cerhan , Cui Tao , Nansu Zong

Question-answering (QA) is a significant application of Large Language Models (LLMs), shaping chatbot capabilities across healthcare, education, and customer service. However, widespread LLM integration presents a challenge for small…

Computation and Language · Computer Science 2023-09-06 Md Adnan Arefeen , Biplob Debnath , Srimat Chakradhar

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

As large language models (LLMs) like OpenAI's GPT series continue to make strides, we witness the emergence of artificial intelligence applications in an ever-expanding range of fields. In medicine, these LLMs hold considerable promise for…

Large Language Models (LLMs) are demonstrating rapid improvements on complex reasoning benchmarks, particularly when allowed to utilize intermediate reasoning steps before converging on a final solution. However, current literature often…

Computation and Language · Computer Science 2026-01-01 Ákos Prucs , Márton Csutora , Mátyás Antal , Márk Marosi

Large Language Models(LLMs) hold promise for improving healthcare access in low-resource settings, but their effectiveness in African primary care remains underexplored. We present a methodology for creating a benchmark dataset and…

Biomedical question answering (QA) poses significant challenges due to the need for precise interpretation of specialized knowledge drawn from a vast, complex, and rapidly evolving corpus. In this work, we explore how large language models…

Computation and Language · Computer Science 2025-09-11 Dima Galat , Diego Molla-Aliod

The integration of Large Language Models (LLMs) into healthcare promises to transform medical diagnostics, research, and patient care. Yet, the progression of medical LLMs faces obstacles such as complex training requirements, rigorous…

Machine Learning · Computer Science 2024-04-26 Emre Can Acikgoz , Osman Batur İnce , Rayene Bench , Arda Anıl Boz , İlker Kesen , Aykut Erdem , Erkut Erdem

This paper presents a comprehensive evaluation of cost-efficient Large Language Models (LLMs) for diverse biomedical tasks spanning both text and image modalities. We evaluated a range of closed-source and open-source LLMs on tasks such as…

Computation and Language · Computer Science 2025-07-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Large language models (LLMs) have significantly advanced natural language processing tasks, yet they are susceptible to generating inaccurate or unreliable responses, a phenomenon known as hallucination. In critical domains such as health…

Computation and Language · Computer Science 2024-09-20 Sumera Anjum , Hanzhi Zhang , Wenjun Zhou , Eun Jin Paek , Xiaopeng Zhao , Yunhe Feng

Automatic relationship extraction (RE) from biomedical literature is critical for managing the vast amount of scientific knowledge produced each year. In recent years, utilizing pre-trained language models (PLMs) has become the prevalent…

Computation and Language · Computer Science 2025-11-04 Mario Sänger , Ulf Leser

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu
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